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12-13-2006, 07:36 AM
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#1
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Senior Member
Join Date: Sep 2005
Location: Grand Rapids, MI
Posts: 1,516
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***Glaxo starts test of Tykerb in early breast cancer***
I want to find out if having Herceptin prior would exclude some of us?
http://today.reuters.com/news/articl...c=66&type=qcna
Rhonda
__________________
Rhonda
Dx 2/1/05, Stage 1, 0 nodes, Grade 3, ER/PR-, HER2+ (3.16 Fish)
2/7/05, Partial Mastectomy
5/18/05 Finished 6 rounds of dose dense TEC (Taxotere, Epirubicin and Cytoxan)
8/1/05 Finished 33 rads
8/18/05 Started Herceptin, every 3 weeks for a year (last one 8/10/06)
2/1/13...8 year Cancerversary and I am "perfect" (at least where cancer is concerned;)
" And in the end, it's not the years in your life that count. It's the life in your years."- Abraham Lincoln
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12-13-2006, 08:01 AM
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#2
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Webmaster
Join Date: Feb 2005
Location: Home of the "Flying Tomato"
Carlsbad, CA
Posts: 2,036
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More on the trial:
http://www.clinicaltrials.gov/ct/sho...374322?order=1
We will discuss the elegibility with GSK while in San Antonio. Tykerb should be FDA approved for Stage IV by March, it could possibly be given "off label" to earlier stage patients.
Regards
Joe
__________________
A Proud webmaster to the internet's most informed, educated, COMPASSIONATE and caring group of breast cancer survivors.
Illegitimi non carborundum
My Album
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12-13-2006, 08:10 AM
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#3
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Senior Member
Join Date: Sep 2005
Location: Grand Rapids, MI
Posts: 1,516
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Thank you Joe...
San Antonio looks to have MANY answers. Take care and God bless.
Rhonda
__________________
Rhonda
Dx 2/1/05, Stage 1, 0 nodes, Grade 3, ER/PR-, HER2+ (3.16 Fish)
2/7/05, Partial Mastectomy
5/18/05 Finished 6 rounds of dose dense TEC (Taxotere, Epirubicin and Cytoxan)
8/1/05 Finished 33 rads
8/18/05 Started Herceptin, every 3 weeks for a year (last one 8/10/06)
2/1/13...8 year Cancerversary and I am "perfect" (at least where cancer is concerned;)
" And in the end, it's not the years in your life that count. It's the life in your years."- Abraham Lincoln
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12-13-2006, 08:11 AM
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#4
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Senior Member
Join Date: Sep 2005
Location: Grand Rapids, MI
Posts: 1,516
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Ps...
are you going to see if they may NOT exclude patients that have had Herceptin? Thank you.
Rhonda
__________________
Rhonda
Dx 2/1/05, Stage 1, 0 nodes, Grade 3, ER/PR-, HER2+ (3.16 Fish)
2/7/05, Partial Mastectomy
5/18/05 Finished 6 rounds of dose dense TEC (Taxotere, Epirubicin and Cytoxan)
8/1/05 Finished 33 rads
8/18/05 Started Herceptin, every 3 weeks for a year (last one 8/10/06)
2/1/13...8 year Cancerversary and I am "perfect" (at least where cancer is concerned;)
" And in the end, it's not the years in your life that count. It's the life in your years."- Abraham Lincoln
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12-13-2006, 08:48 AM
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#5
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Senior Member
Join Date: Sep 2006
Location: Nebraska
Posts: 154
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my dr. is going to give it to me off label when it is available. He already has promised me!! I'm hoping since i'm temporalily on medicare that it will pay for off label cancer drugs. Does anyone know for sure?
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12-13-2006, 09:09 AM
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#6
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Senior Member
Join Date: Sep 2005
Location: Grand Rapids, MI
Posts: 1,516
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Michele...
how long is your onc going to give it to you (i.e. Herceptin for a year which I now see a trial that is testing 6 mo vs 1 yr) or is he going to give it indefinately? Thank you.
Rhonda
__________________
Rhonda
Dx 2/1/05, Stage 1, 0 nodes, Grade 3, ER/PR-, HER2+ (3.16 Fish)
2/7/05, Partial Mastectomy
5/18/05 Finished 6 rounds of dose dense TEC (Taxotere, Epirubicin and Cytoxan)
8/1/05 Finished 33 rads
8/18/05 Started Herceptin, every 3 weeks for a year (last one 8/10/06)
2/1/13...8 year Cancerversary and I am "perfect" (at least where cancer is concerned;)
" And in the end, it's not the years in your life that count. It's the life in your years."- Abraham Lincoln
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12-13-2006, 11:33 AM
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#7
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Senior Member
Join Date: Sep 2006
Location: Nebraska
Posts: 154
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rhonda,
we haven't talked about it yet, but i think i will push for ayear
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12-13-2006, 02:05 PM
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#8
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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I would also like to know if those who have had herceptin might someday be included in a Tykerb trial.
Great information. I emailed my onc as soon as I saw it! Thanks!!
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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12-13-2006, 03:59 PM
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#9
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Senior Member
Join Date: Sep 2005
Location: Maine
Posts: 97
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As long as I pass the EKG and MUGA test, I'll be starting the adjuvant trial they're currently recruiting for after Christmas. It's for people diag. stage I-III who have completed treatment and are currently NED. One of the requirements is that you cannot have received herceptin. It's a random, double blind trial where you are radomized to either receive Tykerb or a placebo and neither your dr. nor you knows which you are receiving and you take it for one year. I was diag. in July 2002 and was unable to receive herceptin as I didn't qualify for a clinical trial so I'm very happy to hopefully being able to take part in this trial.
Pat
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12-13-2006, 07:25 PM
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#10
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Senior Member
Join Date: Nov 2004
Location: Henderson, NE
Posts: 413
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Pat, do you know a link to the trial? I tried to find it and couldn't find the trial. I guess we won't qualify for it if we took Herceptin. I would rather take it off label and know i'm getting it i guess. But i'm sure it won't be cheap
__________________
Michele Ulmer
dx: August 2003 stage 3b 35 pos nodes ER/PR neg Her+
4 AC 12 weekly taxol
one year Herceptin in trial
35 rad tx
vaccine trial Seattle
NED
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12-13-2006, 07:33 PM
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#11
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Senior Member
Join Date: Sep 2005
Location: Maine
Posts: 97
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Hi Michele,
Here's the link http://www.clinicaltrials.gov/ct/sho...374322?order=1
I'm really hoping I get the Tykerb and will be disappointed if I don't. I guess if I get some sort of side effect I'll be able to tell. Being diag. Stage III I want to do all I can...
Take care,
Pat |
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12-17-2006, 08:10 AM
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#12
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Senior Member
Join Date: Nov 2005
Location: Hilton Head Island, SC
Posts: 279
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I left a message on one of the test sites here in Greensboro asking about inclusion for post Herceptin patient. I got a call back very quickly from a man who took my information and said he would investigate and call me back this Monday the 18th. I hope he will have some good news...
tis the season for hope!
__________________
Kim
Diagnosed 7/05
Stage 3a er+(45%) pr+(68%) Her2+ (40%)
3.8 cm + .8cm multi focal - pleomorphic lobular tumors
high grade DCIS
7/20 nodes
BRCA 2 positive as of 5/07
surgeries: double mastectomy, hysterectomy (LAVH)
A/C,Herceptin for 1 year completed 11/06
femara
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12-17-2006, 12:42 PM
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#13
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Kim,
Please let us all know what you learn when you are called back on Monday. I'm sure there are a lot of us Herceptin takers here who would be interested. Thank.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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