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Cancer Lett. 2009 Jun 18;278(2):174-82. Epub 2009 Feb 8.
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Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.
Kwon HK, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH.
Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong, Puk-ku, Gwangju, Republic of Korea.
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.
Mechanism of Action Compounds isolated from Cinnamon mimicked the action of insulin by activating the insulin receptors (17). Cinnamon has been demonstrated to inhibit hepatic HMG-CoA reductase activity and reduce levels of blood lipids in animals and humans; however evidence is conflicting as it has also been shown to raise cholesterol levels in rats (11). Hydroxycinnamaldehyde, a compound present in cinnamon, exhibits anti-inflammatory activity by inhibiting nitric oxide production via inhibition of NF-kappaB (4). top Contraindications # Patients taking blood glucose lowering or blood-thinning medications should use cinnamon extract with caution (4). #
Cinnamon was shown to have estrogenic activity in vitro (19). Patients with hormone sensitive disease should use caution.
Cancer Lett. 2009 Jun 18;278(2):174-82. Epub 2009 Feb 8.
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.
Kwon HK,
Jeon WK,
Hwang JS,
Lee CG,
So JS,
Park JA,
Ko BS,
Im SH.
Department of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryong-dong, Puk-ku, Gwangju, Republic of Korea.
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.
PMID: 19203831 [PubMed - indexed for MEDLINE]
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