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03-13-2007, 01:07 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: Grand Rapids, MI
Posts: 1,516
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***i'ts Official...tykerb Has Been Approved***
__________________
Rhonda
Dx 2/1/05, Stage 1, 0 nodes, Grade 3, ER/PR-, HER2+ (3.16 Fish)
2/7/05, Partial Mastectomy
5/18/05 Finished 6 rounds of dose dense TEC (Taxotere, Epirubicin and Cytoxan)
8/1/05 Finished 33 rads
8/18/05 Started Herceptin, every 3 weeks for a year (last one 8/10/06)
2/1/13...8 year Cancerversary and I am "perfect" (at least where cancer is concerned;)
" And in the end, it's not the years in your life that count. It's the life in your years."- Abraham Lincoln
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03-13-2007, 01:31 PM
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#2
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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...with Xeloda
Whoo Hoo!
Quote from the article Rhonda posted. This means that more trials can start with this drug. Emphasis is mine.
"The regulator approved the once-daily pill in combination with Roche Holding AG's Xeloda for treatment of advanced breast cancer in women who carry the HER-2 gene and don't respond to Roche's Herceptin, London-based Glaxo said today in an e-mailed statement. Tykerb belongs to a class of drugs known as dual- kinase inhibitors, which impede the growth of tumor cells."
This would not prevent an onc from giving it "off label," but I expect most oncs to be conservative in this approach until more data or anecdotal info comes in.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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03-13-2007, 02:14 PM
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#3
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Senior Member
Join Date: Sep 2006
Location: Houston, Texas
Posts: 624
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Yipee!!!!!! Another weapon in our arsenal. I am so glad to finally hear that it has been approved. I am not sure at what point my onc. is going to use it, but I am sure she will.
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03-13-2007, 02:16 PM
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#4
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Member
Join Date: Nov 2006
Location: Dripping Springs, Texas
Posts: 13
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Super news!!!!
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03-13-2007, 02:53 PM
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#5
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Webmaster
Join Date: Feb 2005
Location: Home of the "Flying Tomato"
Carlsbad, CA
Posts: 2,036
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Here is the official GSK press release:
www.her2support.org/tykerb-ok.htm
Regards
Joe
__________________
A Proud webmaster to the internet's most informed, educated, COMPASSIONATE and caring group of breast cancer survivors.
Illegitimi non carborundum
My Album
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03-13-2007, 02:54 PM
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#6
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Senior Member
Join Date: Sep 2005
Location: .
Posts: 211
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Fabulous news! Thank god. Hope approval follows in Australia soon for us guys.
love
linda
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03-13-2007, 03:19 PM
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#7
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Senior Member
Join Date: Jan 2007
Posts: 72
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Fabulous news!
Excellent, excellent news!
__________________
12/01/2006 Initial Dx via stereotactic biopsy - DCIS, grade 3
12/27/2006 Lumpectomy w/ SNB: 2 foci of IDC (largest .3 cm, Grade 2, Notthingham score 6) amid large area of DCIS: No clear margins on the DCIS; re-excision recommended
ER+(55%)/PR+(60+)/HER2+ (2.8+ via IHC?)
01/23/2007 Re-excision Lumpectomy: No clear margins on the DCIS; mastectomy recommended
03/02/2007 Bilateral mastectomy w/ expander implant insertion
03/19/2007 Emergency surgery to fix broken blood vessel in left breast
03/30/2007 Met w/ oncologist; oncologist checking on HER2 status with pathologist and doing some consulting on my case - no treatments for now!
05/02/2007 Next appointment w/ oncologist
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03-13-2007, 03:26 PM
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#8
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Senior Member
Join Date: Feb 2005
Location: Norridgewock, Maine
Posts: 778
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Wow, Rhonda you must have stayed up all night waiting for this!!! Anyway, good news. hugs, Sandy
__________________
Dx. 03/01, Rt. IBC
AC/Taxatere
Rt. MRM-with graft Lt. simple
5 rads-skin mets
Herceptin, taxol, carboplatin (taxol seem to be the magic drug)
Navelbine & xeloda (did not work)
topical miltex for skin mets
Tykerb/xeloda
thoracentesis x 2 left lung fluid shows cancer cells
Port removal (4 years) with power port replacement
Doxil
Updated 05-07 Scans show no bone or organ involvement we shall see!
I shall not pass this way again. Any good I can do or any kindness that I can show let me not defer or neglect it for I shall not pass this way again.
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03-13-2007, 03:36 PM
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#9
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Senior Member
Join Date: Oct 2005
Posts: 823
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WOOO HOOOO I am so glad to read this. Such WONDERFUL news.
__________________
Vicki
Texas
Biopsy Dx'd 3-23-05 Age 48
MRM 4-5-05 w/ 2 tumor's 5cm, and 6 cm (right side)
IDC (poorly differentiated infiltrating ductual carcinoma)
5+/16 nodes
Stage III A
Grade 3
ER/PR-, Her2/neu ++
Ki67 78%
Begin Chemo 5-2-05 4XAC Dose Dense , 4X Abraxane Dose Dense (ended August 05)
28 Rad's ended October 13 2005
Started Herceptin Weekly August 2005 for one year
Had a Simple mastectomy left side after Mamo showed incresed micro-calcifications. Jan. 17 2006.
Brain MRI Feb.2006--All Clear
August 28, 2006 Last Weekly Herceptin.
October 2006--Colonoscopy, 6 Polyp's removed--all B9
PET Scan July 2007
Abdominal MRI Oct. 2007---2 Right Kidney Cysts
Core Biopsy-- Lump on Scar Line 1-10-08---B9
Brain MRI 6-2008--All Clear
PET/CT Scan 6-2008
Sept. 8 2008, 4CM area removed from mastectomy scar line. Proved to be B9.
PET/CT Scan-- July 2009 --All clear
August 17,2009 ---Had Port Removed
6 Years NED -- April 5,2011
DX'd with Melanoma left arm 10-10-2011
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03-13-2007, 04:58 PM
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#10
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Senior Member
Join Date: Jan 2007
Posts: 138
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What great news!!!
Karen
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03-13-2007, 10:23 PM
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#11
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Senior Member
Join Date: May 2006
Location: northshore suburb of chicago
Posts: 1,093
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Awesome, awesome, awesome! Sure hope early stagers will be able to someday also get tykerb on board because of it's ability to cross the blood brain barrier since herceptin doesn't protect the brain at all.
__________________
~Rina~
Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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03-13-2007, 10:27 PM
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#12
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Senior Member
Join Date: Aug 2001
Location: Oregon
Posts: 1,756
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Yeah!!! I think this paragraph is really encouraging also:
"...In a separate statement, Glaxo said it will offer Tykerb for free to low-income Americans without health insurance. Patients enrolled in the Medicare plan for the elderly and disabled may also be eligible if they spend $600 a year on other drugs, Glaxo said...." <O </O<O </O
__________________
Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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03-14-2007, 07:48 AM
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#13
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Senior Member
Join Date: Nov 2004
Location: Olathe, KS
Posts: 107
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Hooray!! Super awesome!
__________________
Rose
Dx'd 1/04 at 33, while 33 weeks pregnant
Dx: Stage IIIC IDC, ER-, PR+ (23%), Her2=2.7 (IDC)/7.6 (FSH), 2.5cm primary tumor, grade III, 11/18+ nodes (largest 3.8 cm)
Treatment: A/C *4, T *4, 1 year of herceptin (BCIRG 006), mastectomy, rads (7 weeks), zoladex (5 years) with tamoxifen (2 years)/aromisin (3 years), bilateral SGAP summer 05 at NOLA
Oops, retested tumor and I guess I'm er/pr- after all.
Stopped all hormonal tx 10/07. Periods resumed 6/08. Bye bye hot flashes!!!!
http://www.edrie.com/kopecky
*~VISIT OUR FAMILY!~*
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