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04-24-2008, 03:07 PM
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#21
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Ky home and Lily,
StephN had had Navelbine + Herceptin for her extensive liver mets, the combo completely cleared them! So the Navelbine is a good drug.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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04-24-2008, 07:39 PM
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#22
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Senior Member
Join Date: Nov 2007
Posts: 210
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hey chrisy... how you been doing... i guess you are on your 4th or 5th.. treatment..
hope all is well
run to live
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04-25-2008, 01:47 PM
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#23
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Senior Member
Join Date: Jun 2007
Posts: 34
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Thanks for the info crisy, Ill private message her for some other questions I have.
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06-10-2008, 06:50 AM
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#24
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Senior Member
Join Date: Nov 2007
Posts: 210
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how you been doing.. ky home.. long time no hear from you..
run
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06-10-2008, 07:07 PM
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#25
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Senior Member
Join Date: Jun 2007
Posts: 34
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hanging in there
Runtolive, thanks for asking. I have been on navelbine & hercepton since feb. and my scans are next week. I have been feeling great and never lost my hair. hooray! The combo has been easy except for some minor gi problems. Im hoping for those new mets to be blasted out.
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06-10-2008, 08:52 PM
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#26
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Feeling great is a good sign! Hope your scans show you're getting the results you want.
Glad to hear you are doing well.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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06-16-2008, 07:03 PM
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#27
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Member
Join Date: Nov 2007
Location: Minneapolis, MN
Posts: 20
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Mcd-!
Hi Chrissy and Lily,
Just wanted to check in and tell you too not give up! The trail has given me NED for the first time in 4 years I am still in shock. Even had to get a copy of the scan to see it in writing. I am so happy to know that the Doctor's are still looking for a cure and that WOMEN like us are willing to give it a try. Thank you for being warrior's as I .
hugs and blessings.
Marsha
__________________
MPB
IDC in 1996 Stage 3 Grade D 17 pos. nodes
2003 liver mets found HER2 Her/Taxol then did the first trail for Trykerb and Xelosa until 11-07
Six new tumors on neck will be starting the MCC_DM1 trail this week.
"Believe in miracles, and watch them happen!"
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06-17-2008, 06:27 PM
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#28
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Marsha,
Thanks for posting your encouraging words. I've been fighting to stay in this trial and I really needed to hear how well you've done on it. I have tests Friday, so am ramping up the scanxiety...your post helped me a lot!
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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06-19-2008, 07:36 PM
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#29
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Senior Member
Join Date: Jun 2007
Posts: 34
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If at first you dont succeed try, try again. I was so bummed with my first scans on the dmi study cause after the results came back I was out into the world of the unknown again. My scans came back after 9 weeks on navelbine and herceptin. They turned out excellent as 2 big spots on my liver were reduced by more than half, other spots vanished. I congradulate barb on her ned which we are all striving for. I also want others to know that even if one fails there is something else out there waiting to help you, so never, never give up.
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06-19-2008, 08:01 PM
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#30
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Great news!
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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06-20-2008, 03:04 AM
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#31
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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Dear Kentucky -
I have been following all you brave souls who are out there in clinical trial land. What a joy to hear that you are doing well on the Navelbine/Herceptin combo.
Actually, I had those two drugs along with TAXOL. That was a tougher combo and naturally my hair went. Taxol is pretty stiff stuff, but it is generally synergistic with Herceptin.
These three drugs made it a 3-pronged attack on the cancer cells, with each working a little differently to kill the cells.
Sometimes the older drugs do the trick. May your next set of scans show even more damage to the cancer.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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06-20-2008, 06:52 AM
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#32
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Senior Member
Join Date: Jun 2007
Posts: 34
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Thanks
Steph thanks for that post cause we all can use the encouragement. Chrissy are you back on track yet with your study? I hope so as I know you were doing so well. I know that if another study came up to help I would try again.
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