Go Back   HER2 Support Group Forums > Herceptin / Tykerb
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Herceptin / Tykerb Share your experiences or ask questions about Herceptin or Tykerb

Thread Tools Display Modes
Old 02-21-2018, 06:59 AM   #1
Join Date: Sep 2013
Posts: 6
Lisa D

Is anybody on Herceptin/Perjeta and suffered a decrease in LVEF? If so, has LVEF recovered when taken off Perjeta?
LISA D is offline   Reply With Quote
Old 02-22-2018, 12:09 PM   #2
Senior Member
Join Date: Oct 2014
Posts: 49
Re: Lisa D

Hi Lisa,

My wife had the same issue while on herceptin alone and she was put on coreg ( minimum dose ) to bring back the LVEF back to normal. Once that was done she continued with Herceptin. As H and P both have cardiotoxicity, your doctor may want to hold it back if your LVEF is below 50% and put you on ace inhibitors like coreg.

Congratulations on successful 16 years and wishing you a lot more.
supportwife is offline   Reply With Quote
Old 02-22-2018, 06:28 PM   #3
Senior Member
Join Date: Oct 2013
Posts: 418
Re: Lisa D

Actually Coreg is a beta blocker like propranalol. This may seem minor to point out but the side effects and contraindications are different. For instance an asthmatic shouldnt take coreg.
donocco is offline   Reply With Quote
Old 02-24-2018, 07:48 AM   #4
Senior Member
Laurel's Avatar
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 1,985
Re: Lisa D


Many here have taken CoQ10 when their echos showed lowered LVEF. In many instances it enabled them to continue Herceptin without interruption. You can Google it for various studies on its affect on cardiac function. I used it during my year of Herceptin therapy.

Smile On!

Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara

11 Years NED
I think I just might hang around awhile....

Laurel is offline   Reply With Quote
Old 02-26-2018, 01:57 PM   #5
Junior Member
Join Date: Jan 2018
Posts: 2
Re: Lisa D

Here is a review of the research on CoQ10 and EF: http://openheart.bmj.com/content/2/1/e000326

They concluded: "Thus, in aggregate, evidence suggests that supplemental CoQ10 may be a useful option for effective management of heart failure, with the advantage of excellent clinical toleranceŚreflecting its status as an essential physiological cofactor."
c1k49 is offline   Reply With Quote
Old 02-27-2018, 05:21 AM   #6
Join Date: Sep 2013
Posts: 6
Re: Lisa D

How much Coq10 should you take a day
LISA D is offline   Reply With Quote
Old 02-27-2018, 07:31 AM   #7
Senior Member
Becky's Avatar
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,156
Re: Lisa D

400 mgs but you have to work up to that amount. For example, for a couple of days take 50 at breakfast and 50 at lunch. Then take 100 at breakfast and 50 at lunch ( also for a couple of days). Then 100 breakfast, 100 lunch and so on. You can try dinner but it makes some people too perky to sleep. When you get to 400 you can decide if you want to split the dose or just take it all at once.
Kind regards


Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 15 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
Becky is offline   Reply With Quote
Old 02-27-2018, 11:08 AM   #8
Senior Member
Join Date: Oct 2013
Posts: 418
Re: Lisa D

Coenzyme Q10 is fat soluble so for better absorption you should take it with a bit of fatty food ie cheese, peanut butter etc.

donocco is offline   Reply With Quote

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump

All times are GMT -7. The time now is 04:56 AM.

Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007
free webpage hit counter