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Diet and Nutrition By popular demand our nutritional message board. This board will be monitored by a Registered RD who is certified in oncology by the American Dietetic Association

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Old 12-14-2009, 07:15 AM   #1
whatz
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Grapefruit?

Somewhere down the line I've heard you are supposed to avoid grapefruit while on chemo. Here are my questions:
1) is this true? if so why?
2) if 1 is true...does this apply to Herceptin as well?
Thanks for answering.
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Old 12-15-2009, 01:25 PM   #2
TanyaRD
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Re: Grapefruit?

Oncolink.org had a good explaination for the potential interaction between chemo and grapefruit. See below.


Dear OncoLink "Ask The Experts,"
I am wondering if you clear up the mystery surrounding the contraindicated use of grapefruit/and or juice during chemotherapy?




Katrina Claghorn, MS, RD, Registered Dietitian at the Abramson Cancer Center of the University of Pennsylvania, responds:
Grapefruit can block the activity of an enzyme in the intestine that is involved in the metabolism of certain medications. Because the medications can't be broken down, blood levels may rise and become toxic. Drugs that are affected include cholesterol lowering medications, beta-blockers for high blood pressure, some psychiatric medicines, immuno-suppressants, and protease inhibitors. The only chemotherapy drug that grapefruit is definitely known to interact with is Vincristine. However, there are concerns about the interaction of grapefruit with other chemotherapy drugs based on our knowledge of the way they function. If you regularly eat grapefruit or drink grapefruit juice, ask your doctor or pharmacist about possible medication and chemotherapy drug interactions. Other citrus foods and juices, such as orange juice, do not appear to interfere with medication metabolism.

Mayo Clinic has a nice chart displaying potential drug interactions.
http://www.mayoclinic.com/health/foo...rition/AN00413
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Old 12-15-2009, 02:44 PM   #3
whatz
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Re: Grapefruit?

Thanks for the info. I guess I'll be OK with the sometimes grapefruit breakfast and Hercepting :-)
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4/09 suspicious lump in left breast
5/09 biopsi lead to diagnosis ER/PR -
Her2+.Grade 3,full masectomy left breast,sentinel nodes clear,Stage 1
6/09 Adriamycin + Cytoxan 4 treatments (every 3 weeks) followed by Taxol + Herceptin, 1 treatment weekly for 12 weeks, followed by Herceptin for 40 weeks
MRI Brain 4/10 clear
CT Body 4/10 clear
PET Body 2/11 clear
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Old 12-16-2009, 06:55 PM   #4
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Re: Grapefruit?

Grapefruit also interferes with Tamoxifen.

all the best
caya
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MRM Dec.18/06
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Old 12-18-2009, 03:37 PM   #5
Sandra in GA
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Re: Grapefruit?

I had to avoid grapefruit while I was on lapatanib (Tykerb). Since I took my last Nov. 18th, I have been enjoying a half almost every morning! That was one of the warning labels they always put on my bottles down at Mayo.
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Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
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Old 12-28-2009, 08:30 AM   #6
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Re: Grapefruit?

You may also want to visit the druginteractioncenter.org website.
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