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Breast Cancer Meeting Highlights News fro recent ASCO and San Antonio Meetings

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Old 05-14-2010, 01:38 PM   #1
Hopeful
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Paradoxical actions of a c-Src inhibitor on long-term ER deprived cells

If I read Lani's post correctly, this test was done on Her2+ cells (MCF-7): http://www.abstractsonline.com/Plan/...5F41EE8117E%7d

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Old 06-25-2010, 11:46 PM   #2
Lani
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Re: Paradoxical actions of a c-Src inhibitor on long-term ER deprived cells

MCF-7 cells , the most commonly used breast cancer cell line in research are her2-. Occasionally you will see studies on MCF-7 cells which are an artificial construct having been transfected (infected with additional genetic material to change them) with her2

So these cells were ER+ and her2-

I have posted a list of the most common her+ cell lines used in research if you

try the search function I think you'll find it

I don't believe they studied what made these particular cells resistant to estrogen deprivation (and sensitive to estrogen causing apoptosis),but from previous work by these authors I don't believe they noted acquisition of her2 amplification as the cause of this change.
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