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Old 04-07-2009, 11:24 AM   #1
Lani
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Join Date: Mar 2006
Posts: 4,778
for those running out of options--interesting research with

available drugs/their derivatives.

One of the cell lines used in the research was BT-474 which is her2+ER+
Some of the cell lines they tested were resistant not only to chemo, but to herceptin

Cancer Lett. 2009 Apr 2. [Epub ahead of print]

Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress.

Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH.
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, 2011 Zonal Ave., HMR-405, CA 90089-9094, United States.
Moderate activity of the endoplasmic reticulum (ER) stress response system exerts anti-apoptotic function and supports tumor cell survival and chemoresistance, whereas its more severe aggravation may exceed the protective capacity of this system and turn on its pro-apoptotic module. In this study, we investigated whether the combination of two pharmacologic agents with known ability to trigger ER stress via different mechanisms would synergize and lead to enhanced tumor cell death. We combined the HIV protease inhibitor nelfinavir (Viracept((R))) and the cyclooxygenase 2 (COX-2) inhibitor celecoxib (Celebrex((R))) and investigated their combined effect on ER stress and on the viability of breast cancer cells. We found that this drug combination aggravated ER stress and caused pronounced toxicity in human breast cancer cell lines, inclusive of variants that were highly resistant to other therapeutic treatments, such as doxorubicin, paclitaxel, or trastuzumab. The anti-tumor effects of celecoxib were mimicked at increased potency by its non-coxib analog, 2,5-dimethyl-celecoxib (DMC), but were substantially weaker in the case of unmethylated-celecoxib (UMC), a derivative with superior COX-2 inhibitory efficacy. We conclude that the anti-tumor effects of nelfinavir can be enhanced by celecoxib analogs in a COX-2 independent fashion via the aggravation of ER stress, and such drug combinations should be considered as a beneficial adjunct to the treatment of drug-resistant breast cancers.
PMID: 19345476 [PubMed - as supplied by publisher]
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Old 04-07-2009, 03:39 PM   #2
R.B.
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Interesting.

COX blockers block down stream chemical products of Omega 6.

This is a thread that I started a while ago that kind of got incorporated into the G(r)eek (-: Diet Thread


http://her2support.org/vbulletin/sho...t=cox+blockers


http://her2support.org/vbulletin/sho...ght=greek+diet
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Old 04-27-2009, 08:43 PM   #3
Believe51
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Location: RHODE ISLAND (Ed getting me a latte on 2nd Cancerversary Cruise 2008) 'BELIEVE': To accept as true or real, To have faith in, To presume ALWAYS BELIEVE
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This one slipped me by while I was away. I just though I would bump this up in case it could benefit others.>>Believe51
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