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Old 06-19-2008, 09:30 PM   #1
G. Ann
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Help-Change in Microcalcifications

Hi
Your wisdom and comments are needed. Since my mastectomy of left breast in 2004, the remaining right breast has had "loosely clustered" microcalcifications. May 28 mammo showed a change of microcalcifications. I went back to radiology today for new pictures--four magnified shots were taken. Saw radiologist and he said he could not tell if they were benign or malignant but there were "more and they are a tighter cluster." He recommended stereotactic procedure. My concern is I'm small breasted (A cup) and I don't think I have enough breast to hang down in the device. Also, saw plastic surgeon last spring and had kicked around idea for reconstruction. Plastic doc also said results are more satisfactory if he's not matching. In remaining breast I've had three cysts, have had two ultrasounds, and two biopsies. I made appt today with original surgeon to have consultation about just removing the breast and bypassing anymore testing. I would appreciate any input.

P.S. I have a picture of a dancer wearing pink ribbons, with the saying: "To our dreamweavers, soulful singers, and ice-cream eaters. To our hope-filled healers, freedom fighters, boundary breakers, and dance all nighters. To our laugh out louders, mercy givers, band-aid bearers, and peaceful wishers, we celebrate with you, our survivor sisters." (copyright--"high hopes, 2004 my chitchats)

The above sentiments fits this website perfectly. For me right now, I'm the "ice-cream eater." Thanking you in advance for your comments.
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G. Ann
DX 2/04, mastectomy, 2.5 cm tumor, grade 3
Her 2 positive, 60%, 3+/strong, ER/PR-
Stage 2, 0/18 nodes
TX 4 AC (no taxanes, no radiation)
Hysterectomy 10/04
Began Herceptin 1/06, finished 1/07
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Old 06-21-2008, 10:20 AM   #2
dhealey
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I would opt to have the breast removed. I had microcalcifications in my unaffected breast and last year had it removed. Pathology showed precancerous activity. I was glad I choose to have it removed. That being said I have not done any reconstruction. I was small breasted anyway and am 53, now I just choose what size I want to be with whatever I am wearing. Good luck to you in your decision.
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Debbie in North Carolina
Diag 10/2006-high grade invasive ductal carcinoma- mastectomy L breast
2.5 cm tumor ER/PR pos-Her2+++
4 rounds A/C, 4 rounds Taxol
Herceptin every 3 weeks until Jan. 2008
6/18/07 prophylatic mastectomy R breast
8/2007 started aromasin/stopped arimidex (side effects)
12/07 stopped aromasin due to side effects (now what?)
Finished herceptin 1/8/08
started tamoxifen for 2 years then will switch to femera
allergic to tamoxifen started femera 4/2008
June 20, 2008 portacath removed
Learnig to live life to the fullest!
Stopped Femera due to side effects
July 28, 2008 start trial for breast cancer vaccine
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Old 06-21-2008, 06:34 PM   #3
Becky
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I am thinking about you. I had cancer on one side and dcis on the other with double lumpectomies (idiotic when I think about not getting the dear girls removed but I didn't know anything then).

First, get a good biopsy - perhaps a lumpectomy type and see what you're dealing with. Then decide what to do. I am thinking about you because this is a bloody difficult disease but you will know in your heart the right thing to do.
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 06-22-2008, 04:56 AM   #4
Sheila
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I can only echo what Becky has said...definately a biopsy or lumpectomy...my journey started with microcalcifications, that turned out to be invasive ductal, we can never be too careful...You are in my thoughts and prayers for good results whatever you choose to do.
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"Be kinder than necessary, for everyone you meet
is fighting some kind of battle."



Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 06-22-2008, 08:29 AM   #5
Becky
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I just wanted to add why I said a "lumpectomy" type biopsy. It is because sometimes these things are so small that a needle can miss it and the biopsy comes back "benign" when it really missed the dcis.

When I had my lumpectomy on my cancer the surgeon said she "thought" she saw some micro calcifications on the other side and wanted to do a surgical biopsy on that side because I was already going to be put out.

She didn't think it would be anything but it was a 3mm dcis (low grade). A needle might have missed it and it ended up being "alittle" something.
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 06-22-2008, 05:32 PM   #6
G. Ann
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Hi Becky, Sheila, & dhealy,
Thanks for your input. Since my first post, I'm now scheduled for stereotactic biopsy on July 2nd. I also saw surgeon and he Ok'd mastectomy even if benign findings. The stereotactic biopsy would aid the surgeon if it was malignant as far as checking lymph nodes & sentinel nodes. Otherwise, I think I'd skip it.

It's been 4-1/2 years and I don't even want to think about chemo, radiation, etc. So first things first. I'm feeling less anxious (except for the stereotactic procedure) since there's a plan in place. The results from stereotactic will help me decide about doing reconstruction at the same time if it's just a prophylactic mastectomy and no BC evident.

Thanks again for your encouragement, prayers, & great Winnie-the-Pooh quote.
__________________
G. Ann
DX 2/04, mastectomy, 2.5 cm tumor, grade 3
Her 2 positive, 60%, 3+/strong, ER/PR-
Stage 2, 0/18 nodes
TX 4 AC (no taxanes, no radiation)
Hysterectomy 10/04
Began Herceptin 1/06, finished 1/07
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Old 06-25-2008, 12:47 AM   #7
jhandley
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Get it off asap. My recurrence only showed a couple of microcalcifications,,nothing on ultrasound and guess what they found on surgery...4 cm tumour and one spot to liver.

Last edited by jhandley; 06-25-2008 at 12:48 AM.. Reason: typo
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Old 06-25-2008, 10:58 PM   #8
harrie
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G. Ann, I have also been thinking about your thead. I read it quickly today and then tonight searched and searched and FINALLy found it!
I had DCIS on both breasts, lumpectomies in BOTH breasts, rads in both breasts. (about 6 yrs apart per breast) This does not include the numerous bioposy that showed negativity, ultrasounds and you name it.
In 2006 I finally had my bilat mastectomy with reconstruction.

What I wanted to say in regards to your situation, if there may be any doubt that the stereotactic biopsy could miss the calcification that does show cancer cells, being that you said there is a cluster of calcifications, then I would highly recommend you go for the mastectomy.

I was also very small like you. When I look back, lumpectomies to conserve my breasts were in reality more like partial mastectomies anyways! I am very content and happy with my mastectomy and reconstruction.
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*** MARYANNE *** aka HARRIECANARIE

1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen

2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy

2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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Old 06-25-2008, 11:00 PM   #9
harrie
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G.Ann,one more thing, I had my mastectomy and reconstruction done at the same time. If you ck my profile, I was stage I.
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*** MARYANNE *** aka HARRIECANARIE

1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen

2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy

2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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Old 06-26-2008, 11:00 PM   #10
G. Ann
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Join Date: Mar 2006
Posts: 78
Hi Harrie & jhandley,
I so appreciate your posts and the earlier ones. It really makes a difference to share my concerns and fears and have people I don't even know take time to answer and share your experiences.

I am convinced I need to get the remaining breast removed. If the stereotactic biopsy comes back negative for cancer, I won't confident it's accurate. I guess you never totally know for sure, but I've felt for three years that I should have it removed since the first ultrasounds & biopsies.

Today is my birthday and of course I'm thankful for family and friends that I know. But this also is such a wonderful website and wealth of information plus caring hearts--- I am very grateful for all of you.
G. Ann
__________________
G. Ann
DX 2/04, mastectomy, 2.5 cm tumor, grade 3
Her 2 positive, 60%, 3+/strong, ER/PR-
Stage 2, 0/18 nodes
TX 4 AC (no taxanes, no radiation)
Hysterectomy 10/04
Began Herceptin 1/06, finished 1/07
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Old 06-26-2008, 11:13 PM   #11
harrie
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Happy Birthday G. Ann!!!
What is really REALLY good about the information shared here is that when you finally make that decision.....you know in your heart that it was a very good one.
And to me that is half the battle.
__________________
*** MARYANNE *** aka HARRIECANARIE

1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen

2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy

2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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Old 06-26-2008, 11:17 PM   #12
SoCalGal
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Hi - Two more thoughts -
I had bilateral and NOTHING in the other breast but I'm glad I did the bilateral because when I had a recurrence I was "done" messing around and taking chances AND I also had a stereo tactic biopsy in which they "confirmed" "having" the area w/micro calcifications in the needle/biopsy. The report was negative BUT the radiologist was expecting other news from the mammogram and said that although it was negative and they were sure they had the correct sample - she was not comfortable with that result and strongly recommended a surgical biopsy. That was how they found my recurrence.
So - if you want my advice - I'd go with a surgical biopsy and then make decisions from there. I think that would give you peace of mind on the area.
Flori
__________________
1996 cancer WTF?! 1.3 cm lumpectomy Er/Pr neg. Her2+ (20nodes NEGATIVE) did CMF + rads. NED.
2002 recurrence. Bilateral mastectomy w/TFL autologous recon. Then ACx2. Skin lymphatic rash. Taxotere w/Herceptin x4. Herceptin/Xeloda. Finally stops spreading.
2003 - Back to surgery, remove skin mets, and will have surgery one week later when pathology can confirm margins.
‘03 latisimus dorsi flap to remove skin mets. CLEAN MARGINS. Continue single agent Herceptin thru 4/04. NED.
‘04 '05 & 06 tiny recurrences - scar line. surgery to cut out. NED each time.
1/2006 Rads again, to scar line. NED.

3/07 Heartbreaking news - mets! lungs.sternum. Try Tykerb/Xeloda. Tykerb/Carbo/Gemzar. Switch Oncs.
12/07 Herceptin.Tykerb. Markers go stable.
2/8/08 gamma knife 13mm stupid brain met.
3/08 Herceptin/tykerb/avastin/zometa.
3/09 brain NED. Lungs STABLE.
4/09 attack sternum (10 daysPHOTONS.5 days ELECTRONS)
9/09 MARKERS normal!
3/10 PET/CT=manubrium intensely metabolically active but stable. NEDhead.
Wash out 5/10 for tdm1 but 6/10 CT STABLE, PET improving. Markers normal. Brain NED. Resume just Herceptin plus ZOMETA
Dec 2010 Brain NED, lungs/sternum stable. markers normal.
MAR 2011 stop Herceptin/allergy! Go back on Tykerb and switch to Xgeva.
May-Aug 2011 Tykerb Herceptin Xgeva.
Sept 2011 Tykerb, Herceptin, Zometa, Avastin.
April 2012 sketchy drug trial in NYC. 6 weeks later I’m NED!
OCT 2012 PET/CT shows a bunch of freakin’ progression. Back to LA and Herceptin.avastin.zometa.
12/20/12 add in PERJETA!
March 2013 – 5 YEARS POST continue HAPZ
APRIL 2013 - 6 yrs stage 4. "FAILED" PETscan on 4/2/13
May 2013: rePetted - improvement in lungs, left adrenal stable, right 6th rib inactive, (must be PERJETA avastin) sternum and L1 fruckin'worsen. Drop zometa. ADD Xgeva. Doc says get rads consultant for L1 and possible biopsy of L1. I say, no thanks, doc. Lets see what xgeva brings to the table first. It's summer.
June-August 2013HAPX Herceptin Avastin Perjeta xgeva.
Sept - now - on chemo hold for calming tummy we hope. Markers stable for 2 months.
Nov 2013 - Herceptin-Perjeta-Avastin-Xgeva (collageneous colitis, which explains tummy probs, added Entocort)
December '13 BRAIN MRI ned in da head.
Jan 2014: CONTINUING on HAPX…
FEB 2014 PetCT clinical “impression”: 1. newbie nodule - SUV 1.5 right apical nodule, mildly hypermetabolic “suggestive” of worsening neoplastic lesion. 2. moderate worsening of the sternum – SUV 5.6 from 3.8
3. increasing sclerosis & decreasing activity of L1 met “suggests” mild healing. (SUV 9.4 v 12.1 in May ‘13)
4. scattered lung nodules, up to 5mm in size = stable, no increased activity
5. other small scattered sclerotic lesions, one in right iliac and one in thoracic vertebral body similar in appearance to L1 without PET activity and not clearly pathologic
APRIL 2014 - 6 YRS POST GAMMA ZAP, 7 YRS MBC & 18 YEARS FROM ORIGINAL DX!
October 2014: hold avastin, continue HPX
Feb 2015 Cancer you lost. NEDHEAD 7 years post gamma zap miracle, 8 years ST4, +19 yrs original diagnosis.
Continue HPX. Adding back Avastin
Nov 2015 pet/ct is mixed result. L1 SUV is worse. Continue Herceptin/avastin/xgeva. Might revisit Perjeta for L1. Meantime going for rads consult for L1
December 2015 - brain stable. Continue Herceptin, Perjeta, Avastin and xgeva.
Jan 2016: 5 days, 20 grays, Rads to L1 and continue on HAPX. I’m trying to "save" TDM1 for next line. Hope the rads work to quiet L1. Sciatic pain extraordinaire :((
Markers drop post rads.
2/24/16 HAP plus X - markers are down
SCIATIC PAIN DEAL BREAKER.
3/23/16 Laminectomy w/coflex implant L4/5. NO MORE SCIATIC PAIN!!! Healing.
APRIL 2016 - 9 YRS MBC
July 2016 - continue HAP plus Xgeva.
DEC 2016 - PETCT: mets to sternum, lungs, L1 still about the same in size and PET activity. Markers not bad. Not making changes if I don't need to. Herceptin/Perjeta/Avastin/Xgeva
APRIL 2017 10 YEARS MBC
December 2017 - Progression - gonna switch it up
FEB 2018 - Kadcyla 3 cycles ---->progression :(
MAY30th - bronchoscopy, w/foundation1 - her2 enriched
Aug 27, 2018 - start clinical trial ZW25
JAN 2019 - ZW25 seems to be keeping me stable
APRIL 2019 - ONE DOZEN YEARS LIVING METASTATIC
MAY 2019 - progression back on herceptin add xeloda
JUNE 2019 - "6 mos average survival" LMD & CNS new single brain met - one zap during 5 days true beam SBRT to cord met
10/30/19 - stable brain and cord. progression lungs and bones. washing out. applying for ds8201a w nivolumab. hope they take me.
12/27/19 - begin ds8401a w nivolumab. after 2nd cycle nodes melt away. after 3rd cycle chest scan shows Improvement, brain MRI shows improvement, resolved areas & nothing new. switch to plain ENHERTU. after 4th cycle, PETscan shows mostly resolved or improved results. Markers near normal. I'm stunned but grateful.
10/26/20 - June 2021 Tucatinib/xeloda/herceptin - stable ish.
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Old 06-27-2008, 05:05 AM   #13
Becky
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Location: Stockton, NJ
Posts: 4,179
For the same reason as Flori, my almost 2cm tumor was biopsied with inconclusive results and I wanted it out because I have an aunt who died from bc because she was told a lump was nothing (for 4 yrs and it was a tumor and she had 19 nodes involved). So out came my Her2+ tumor (and the calcifications on the other side that was low grade dcis). So I believe in surgical biopsy because they take a chunk out and at least get some of the suspicious area.

You know we are all here to help each other as much as possible
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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