What drug combo will be next?

Janet Taylor · 07-07-2008, 05:29 AM

The year I did Herceptin, the only thing I was taking was Herceptin.

Is Navelbine given through an IV or is it an oral chemo?

chrisy · 07-07-2008, 09:01 AM

Navelbine is an IV chemo, and I also know of people who have done well with this + Herceptin for lung mets.

As for redoing Herceptin, that is very common to continue with Herceptin and just add a chemo because you can still get synergy by adding Herceptin.

Now that Tykerb is approved, I expect you could alternate herceptin and tykerb combinations as well as use them together (there are trials ongoing for this). The point is, continue to target the Her2 with something and boost it with chemo as needed.

Brenda's question is also important, if you have used a taxane, because these work well with Herceptin. But so does Navelbine.

Let us know what you decide.

schoonder · 07-07-2008, 12:51 PM

Janet, Genentech just about completed a 100+ patient Herceptin-DM1 trial, it was conducted at 40 some sites and recruited from MBC patients that had progressed on Herceptin. Company sounds very excited about results they seen so far. A new phase II is scheduled to start this month, an additional inclusion item is that candidates have been exposed to Tykerb and/or Xeloda.

Side effects from drug are minimal! Mention the trial to your oncologist.
Here's a link that will give you further information.

http://www.clinicaltrials.gov/ct2/sh...erm=dm1&rank=3