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Old 03-20-2005, 07:13 PM   #1
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This is a 6 page article:

Can Schedule/Sequence Alterations Affect Outcomes?
Evaluating New Therapeutic Regimens in the Metastatic Setting
Future Directions in Chemotherapeutic Management

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Old 03-20-2005, 08:34 PM   #2
al from canada
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Great article Merridith.
One thing all of these articles refers to is Response Rate, Time to Disease Progression (TTP), and Overall Survival (OS). My question is: many of these novel therapies or novel combinations have a significantly different TTP but have a non-significant OS. In otherwords, why is it if we can stall the TTP you still died just as early as the lower TTP study arm? Is this a statistical anomoly or a medical fact?
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