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02-26-2010, 01:13 AM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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thought you would like to read this--REAL HOPE OF A CURE
OPEN ACCESS: EDITORIAL: Whither HER2-Related Therapeutics?
[Journal of Clinical Oncology]
It is apparent that increasing knowledge of molecular signaling pathways regarding HER2/Neu amplified breast cancer biology has paved the way toward novel, innovative targeted combination therapeutics. The multiplicity of potential targets along the PI3K-AKT-mTOR or HER2-GRB7-RAC1 pathway requires careful preclinical evaluation to ensure optimal activity, minimal toxicity, and lack of resistance. The sheer multiplicity of approaches outlined above will need to correspond to measurements of driving molecular signaling pathways on an individual patient basis. In the meantime, the patient faces a panoply of HER2-directed therapies and state-of-the-art clinical trials, yielding better responses, survival, quality of life, and real hope of a cure.
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02-26-2010, 03:23 AM
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#2
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Re: thought you would like to read this--REAL HOPE OF A CURE
Lani,
Thanks for sharing this. It's very encouraging.
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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02-26-2010, 06:25 AM
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#3
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Senior Member
Join Date: Feb 2008
Location: Georgia
Posts: 1,486
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Re: thought you would like to read this--REAL HOPE OF A CURE
Thanks for the article, Lani. Hope a cure is found soon.
Amelia
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02-26-2010, 07:37 AM
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#4
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Senior Member
Join Date: Feb 2009
Posts: 1,526
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Re: thought you would like to read this--REAL HOPE OF A CURE
Yeah!! I remember reading that an American breast onc professor last year said that he believed in 5 years no women would need to die from her 2 bc. There may not be a cure but that they would have the ability to control it.
Praying that 5 years becomes this year.
Ellie
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02-26-2010, 07:49 AM
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#5
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Member
Join Date: Mar 2009
Posts: 7
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Re: thought you would like to read this--REAL HOPE OF A CURE
Amen to that!
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02-26-2010, 08:36 AM
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#6
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Senior Member
Join Date: Feb 2010
Location: TN
Posts: 175
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Re: thought you would like to read this--REAL HOPE OF A CURE
Yes, there is great promise for curing this disease. We all are praying that it comes sooner than later. On the other hand, the "panoply of HER2-directed therapies" now faced by the patient is almost too much to bear at times as we try to sort them all out. Those of us who have oncologists and groups like this one that can intelligently help guide us with the choices are the fortunate ones.
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02-26-2010, 12:12 PM
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#7
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: thought you would like to read this--REAL HOPE OF A CURE
Can you update with a link? Sounds interesting.
I just hope they don't overlook potential pan-cancer achille's heels while swimming in the "panoply". |
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02-26-2010, 01:05 PM
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#8
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Senior Member
Join Date: Aug 2008
Location: San Francisco
Posts: 260
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Re: thought you would like to read this--REAL HOPE OF A CURE
Thank you, Lani!
I have been following the Herceptin/PI3 kinase inhibitor combination for a while. Check out this poster from a company named ARRAY which makes a PI3 kinase inhibitor called ARRY 380. It shows that, in lab mice, this combo had a 100% cure rate!
http://www.arraybiopharma.com/_docum...achment337.pdf
ARRY 380 is currently in clinical trial as a single agent at M.D. Anderson.
However, for those of you interested in a clinical trial combining BOTH a version of Herceptin (T-DM1) and a PI3 kinase inhibitor, Dana Farber currently has one in a Phase I trial. I met with Dr. Ian Krop in December to discuss joining but he suggested I wait until it reaches Phase II as it is coming to UCSF - where I live. Here is a link to the Dana Farber trial:
http://clinicaltrials.gov/ct2/show/N...cr=Open&rank=6
__________________
4/17/08: Dx Stage IV at age 30 - extensive mets to liver, lungs, and bones. Er/Pr-, Her2+++
April 08-Aug 08:Taxotere, Cytoxan, Herceptin, Zometa - complete response!
Sept 08-Dec 08: Herceptin +Zometa for maintenance.
Jan 09-April 09: Brain mets. Add Tykerb. Watch and wait.
April 09: Gamma Knife 10 brain mets, add Xeloda.
Sept 09: Gamma Knife to 1 brain met.
Nov 09- April 10: Lung progression, add Gemzar to Herceptin, Zometa.
May 10- Sept 10: HER2 Vaccine Trial
Sept 10: Add Tykerb for more brain mets.
Oct 10: Gamma Knife to 7 brain mets.
Dec 10: Switch from Zometa to Denosumab.
Jan 11: Gamma Knife to 3 brain mets.
March 11: Gemzar/Herceptin for lung/bone progression.
April 11: More brain mets - Intrathecal Herceptin
June 11: Ixempra/Herceptin for lung, soft tissue progression.
Aug 11: Gamma Knife
Sep 11: Abraxane/Herceptin
Future: NED
Send me a PM if you'd like to follow my journey on Caringbridge.
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02-26-2010, 01:54 PM
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#9
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Re: thought you would like to read this--REAL HOPE OF A CURE
Lani and Courtney....
A big thank you...
These are important evidence based information and demonstrate the positive research that is being done now. We all are praying for a break through.
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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02-26-2010, 02:40 PM
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#10
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Re: thought you would like to read this--REAL HOPE OF A CURE
Rich, Hope this link is what your looking for?
http://jco.ascopubs.org/cgi/content/full/28/7/1091
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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02-26-2010, 06:01 PM
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#11
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: thought you would like to read this--REAL HOPE OF A CURE
Thanks......adding dots to make post long enough....
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02-26-2010, 06:25 PM
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#12
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Senior Member
Join Date: May 2008
Location: Hershey, PA. Live The Sweet Life!
Posts: 2,005
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Re: thought you would like to read this--REAL HOPE OF A CURE
You guys have me so excited! How am I going to sleep tonight? Courtney, that is so great! Let us know if you do enter the trial. Lani, fantastic news for all of us. Thanks!
Hey, here's a thought: if they do actually find a Her-2 cure, let's all meet at an appointed hour in an appointed place somewhere in the word for a drink and chocolate! Hey, we can do both in a chocolate martini! Ha! There's the ticket!
Sheesh....I'm giddy!
__________________
Smile On!
Laurel
Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara
15 Years NED
I think I just might hang around awhile....
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02-26-2010, 08:19 PM
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#13
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Senior Member
Join Date: Sep 2005
Posts: 556
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Re: thought you would like to read this--REAL HOPE OF A CURE
Courtney,
Any idea when is the trial coming to UCSF? I goto UCSF too.
thanks,
Julie
__________________
Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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02-27-2010, 02:22 AM
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#14
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Senior Member
Join Date: Feb 2009
Posts: 1,526
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Re: thought you would like to read this--REAL HOPE OF A CURE
My onc has been going on about P13 inhibition each time I meet him. He is convinced that harnessing this would result in a quantum shift in treatment!!
So girls i am saving up my money so I can come and see you all if a trial becomes available!! Might even manage a chocolate with Laurel.
Hanging in there for the CURE
Ellie
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02-27-2010, 02:48 AM
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#15
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: thought you would like to read this--REAL HOPE OF A CURE
Ellie,
While pharma works out the patents and trials, consider Honokiol or IP-6.
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02-27-2010, 11:39 AM
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#16
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Senior Member
Join Date: Sep 2005
Posts: 556
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Re: thought you would like to read this--REAL HOPE OF A CURE
Rich,
Do you know where to get Honokiol or IP-6?
Thanks,
Julie
__________________
Diagnosed in Sept 2004 while pregnant with the second child. Stage 3b, tumor 4.5cm, 4 auxillary and supraclav node positive. Her2+++ FISH 9.4 and er-,pr-.
Had dose dense neoadjuvant AC,Taxol then mastectomy,radiation+xeloda+Herceptin.
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02-27-2010, 12:28 PM
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#17
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: thought you would like to read this--REAL HOPE OF A CURE
Some honokiol(magnolia) sources on Google HERE
Combo with Honokiol HERE
IP-6 HERE
I have seen a form of IP-6 in Walgreens.
Seems like liposomal versions of supplements are preferrable when available.
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03-01-2010, 03:33 PM
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#18
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Senior Member
Join Date: Aug 2008
Location: San Francisco
Posts: 260
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Re: thought you would like to read this--REAL HOPE OF A CURE
Laurel - I will be there to celebrate the cure with you - chocolate martini in hand! It is coming, I KNOW IT!
Julie - I asked Melisko when the trial was coming to UC and she said "a few months" so that could mean 2 or 6, I don't really know. She was going to ask Rugo. I'd ask them about it the next time you are there. Let me know what they say. I don't actually go to UC for treatment but I occasionally consult with Melisko for second opinions.
__________________
4/17/08: Dx Stage IV at age 30 - extensive mets to liver, lungs, and bones. Er/Pr-, Her2+++
April 08-Aug 08:Taxotere, Cytoxan, Herceptin, Zometa - complete response!
Sept 08-Dec 08: Herceptin +Zometa for maintenance.
Jan 09-April 09: Brain mets. Add Tykerb. Watch and wait.
April 09: Gamma Knife 10 brain mets, add Xeloda.
Sept 09: Gamma Knife to 1 brain met.
Nov 09- April 10: Lung progression, add Gemzar to Herceptin, Zometa.
May 10- Sept 10: HER2 Vaccine Trial
Sept 10: Add Tykerb for more brain mets.
Oct 10: Gamma Knife to 7 brain mets.
Dec 10: Switch from Zometa to Denosumab.
Jan 11: Gamma Knife to 3 brain mets.
March 11: Gemzar/Herceptin for lung/bone progression.
April 11: More brain mets - Intrathecal Herceptin
June 11: Ixempra/Herceptin for lung, soft tissue progression.
Aug 11: Gamma Knife
Sep 11: Abraxane/Herceptin
Future: NED
Send me a PM if you'd like to follow my journey on Caringbridge.
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03-02-2010, 02:04 PM
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#19
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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Re: thought you would like to read this--REAL HOPE OF A CURE
IP - 6 - I used to get a good one at my local GNC store. I see that there are a few different trustworthy companies offering it at my local supplements specialty store. I don't take it now.
Personally, I do not get any supplements at Walgreens. Too many formulations from who knows where. I will pay a little more for best quality after what I have been through!
Looks like some exciting trials not far down the road. Please, girls, keep us posted.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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01-06-2011, 04:16 PM
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#20
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Guest
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Re: thought you would like to read this--REAL HOPE OF A CURE
Sorry... any news about that PI3 kinase inhibitor?
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