natural fatty acid which might protect heart vs anthracycline-induced cardiomyopathy

ABSTRACT: Oleylethanolamide Activates Ras-Erk Pathway and Improves Myocardial Function in Doxorubicin-Induced Heart Failure [Endocrinology; Subscribe]
Oleylethanolamide (OEA) is a natural fatty acid ethanolamide produced in the heart, but its biological actions in myocardium have not yet been defined. This study was carried out to determine whether OEA could be used to prevent the development of heart failure or improve evolving heart failure. We studied in vivo and in vitro actions of OEA in cardiac muscle. In an animal model of doxorubicin cardiomyopathy, OEA showed robust effects and attenuated the progression of systolic/diastolic dysfunction and ventricular remodeling. During evolving doxorubicin cardiomyopathy, a therapeutic course of OEA treatment partially restored myocardial function. The preventive and therapeutic effects of OEA were associated with significant improvement of survival. To investigate the mechanism of OEA action in cardiac muscle, we have carried out in vitro experiments in cultured cardiomyocytes. The results showed that OEA, through activation of Ras-Raf-1-Mek-Erk signaling, inhibited doxorubicin-induced apoptosis. Additional experiments showed that OEA activation of the Erk pathway involved activation of Neu/ErbB2 receptor, which suggests OEA actions in cardiac muscle might require activation of Neu/ErbB2. In summary, OEA improved ventricular remodeling and augmented cardiac function in doxorubicin cardiomyopathy, possibly involving activation of Neu/ErbB2 and Ras-Erk signaling. These findings suggest OEA is a novel cardioprotective compound that may be used to develop new strategies for the management of cardiomyopathy.

I came across OEA recently too.

From what I read OEA is a potential appetite suppressant and body weight regulator, and is the subject of interest to weight builders.

It also reported as a PPAR alpha agonist.

These factors are all in the mix with leptin insulin omega three six etc.

From all I read balancing the threes and sixes and fish oil supplements are extreemly helpful in the fight against inflamation related disease, which includes some cancers.

Thanks for the post.

RB

[al from Canada]

" Additional experiments showed that OEA activation of the Erk pathway involved activation of Neu/ErbB2 receptor, which suggests OEA actions in cardiac muscle might require activation of Neu/ErbB2."

OK, I need help understanding this one. Doesn't nue/ErbB2 = HER2??

Then why would we want to stock-up on OEA which according to the quote above, activates Nue/erbB2?
From another article:

"Interestingly, overexpression especially of ErbB2, appears to force the equilibrium toward spontaneous homodimer formation leading to activation in the absence of ligands (Samanta

et al., 1994). This situation is often present in a variety of human cancers (Klapper et al., 2000)."

Correct me if I am wrong but the way I read this is in order to correct cardio problems, you should take OEA which has been shown to activate HER2?

Here is the essence of the problem: I've read a lot of studies and xonsider myself fairly literate however, in my attempt to understand exactly what is being said here, I question my interpretation. I wonder about the rest of the people on this site who are struggling to make sence out of this stuff because, as far as they can see; their lives depend on it.

I can't help but wonder if posting these studies is doing anyone any favours?? I am as guilty as anyone else but I am just thinking about this with all due respect to others who post. I would hate to see others start taking OEA when it might up-regulate HER2/neu.

I'm sure I'm going to get slammed for my comments but pre-trial information just doesn't make a lot of sence sometimes. Maybe we should stick to hard in vivo facts and as a curtosy, translate this into terms we can all understand.

Respectfully,
Al

I am sorry your wife is struggling with brain mets.

You must be frustrated by the lack of clear-cut answers, lack of availability of drugs in the pipeline, difficulties dealing with the health service in Canada, etc.

I wrote out a reply to your inquiries, but decided not to post them as all I sensed was frustration on your part (and perhaps hostility)

I think you also underestimate the ladies of the board--I doubt they would go out and try to buy OEA based on the article posted


I wish you the VERY BEST and will not add to your annoyance by posting my reply to your confusion on this topic--like much in this awful disease things are complex and raise further questions.

An ancient home in Pompeii destroyed by the eruption of Vesuvius had scrawled on its wall the following: I want it ALL NOW

We ALL want the answers, but understanding and progress seems to come in little steps.

Just like the fact that there is noone forcing People to buy the newspapers with the Danish cartoons if it offends them, noone is FORCING you to read my posts.

I will always try to remember to put my name on them so you can be SURE not to click on them. (BUT I HAVE NO PLANS TO STOP POSTING.) No reason to annoy yourself when you are busy worrying about finding practical immediate solutions for your wife--I mean this whole-heartedly, not in any condescending manner!

There are many reasons people post on this board and many reasons people come to this board to read.

Like any other gathering of people, many have different motivations, characteristics and "styles"

Again, I commisserate with you and your situation. Let me not add further to your worries/burdens/frustrations.

[al from Canada]

Dear Lani,

You missed the point, it wasn't about my wife, frustrations, Canada, Pompeii or Danish cartoons, as I as hoping for an intellectual exchange, but your subsequent post title "another useless post" was hurtful.

I did not disrespect you and didn't deserve this. I just don't get it but enough is enough. I think I'll follow others' lead and take some time off as the absolute last reason I post here is to piss people off.
Al

[Lolly]

Lani, regarding your comment in your response to Al;

"...There are many reasons people post on this board and many reasons people come to this board to read..."

I feel your postings of research articles, while always interesting, belong on the Articles of Interest page, unless of course you're responding to a specific request on this board.

Joe, correct me if I'm wrong, but I've always thought that's why the site has several different boards to serve the various purposes of this site.

<3 Lolly

[Sheila]

Lani & Al
First to Lani, I would have to agree with Lolly that these articles belong on another section of the board....we are all looking for that magic cure...I enjoy reading new info, but am always cautious until there is proof...guess that is the nurse coming out in me...nonetheless, I read all i can on what may be promising to me in the future...so keep posting as a FYI to let others know when you find something like this...if nothing else, it keeps my brain active reading it.

Al,
You really need to reconsider...I for one would miss your info and encouragement to others....Linda is very lucky to have you fighting for her....many women on this board, including myself are somewhat in this alone...married or single, doesn't matter...they go to the Dr's alone, get treatments alone, get the test results alone...it isn't fun...many on this board are envious of the caregiver Linda has...and you are more knowledgeable than many of us BC survivors because you are always researching. I for one appreciate that from you, and anyone else who takes the time to help us find a way to calm our fears, find that hope, get us to NED! There are many days that this board is the only place I can go and talk to others....others who are living this nightmare with me. Everyone on this board has given me something, knowledge, coping skills, hope, and food for thought...even the kind that I disagree with. Please Reconsider....we need your support!