My 37 y/o Mom had a standard simple mastectomy on a 2.1cm primary and other area of bc calcifications...no neo adjuvant therapy.
Looks like some "high risk" patients can opt for the same approach in an adjuvant setting(at M.D. Anderson). This is a new approach with limited data but do you think it would beat a standard AC regimen due to its addition of herceptin? They used epirubicin in place of adriamyacin. I suppose it makes a difference whether the patient responds to herceptin but, at least in Anderson labs, they have found a protein called Pten which in higher amounts correlates with herceptin sensitivity:
http://www.wkmc.com/cancerftr/CancerNews/082404.asp
Any thoughts?