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Old 02-14-2011, 10:26 AM   #1
Lani
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Join Date: Mar 2006
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Thumbs up new paper denies increased risk of recurrence w wt gain after diagnosis of Stages 1-3

Feel like celebrating with a piece of chocolate???

Breast Cancer Research and Treatment
Volume 99, Number 1, 47-57, DOI: 10.1007/s10549-006-9179-y

Epidemiology
Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

Bette J. Caan, Jennifer A. Emond, Loki Natarajan, Adrienne Castillo, Erica P. Gunderson, Laurel Habel, Lovell Jones, Vicky A. Newman, Cheryl L. Rock and Martha L. Slattery, et al.

Journal Article

Purpose
To examine whether weight gain after diagnosis of breast cancer affects the risk of breast cancer recurrence.
Patient and methods
Patients included 3215 women diagnosed with early stage breast cancer (Stage I >1 cm., II, and IIIA) who were enrolled either in an observational cohort of breast cancer survivors or were part of the comparison group of a dietary intervention trial to prevent breast cancer recurrence. We computed weight change from 1 year prior to diagnosis to study enrollment. Delayed entry Cox proportional hazards models were used to evaluate associations of categories of weight change with time to recurrence, controlling for known prognostic factors.
Results
Neither moderate (5–10%) nor large (> 10%) weight gain (HR 0.8, 95% CI, 0.6–1.1; HR 0.9, 95% CI, 0.7–1.2, respectively) after breast cancer diagnosis was associated with an increased risk of breast cancer recurrence in the early years post-diagnosis (median time of 73.7 months from diagnosis).
Conclusion
Our research provides evidence that weight gain commonly seen in the first several years following a breast cancer diagnosis does not increase a woman’s risk for breast cancer recurrence in the first 5–7 years post-diagnosis. However, this research does not address the effects of weight gain on overall survival or on the risk of other new cancers, other prognostic outcomes of concern to the breast cancer survivor.

Keywords BMI - breast cancer - prognosis - recurrence - weight gain
For the Life After Cancer Epidemiology (LACE) Study group (Bette J. Caan, Adrienne Castillo, Erica P. Gunderson, Laurel Habel, Martha L. Slattery, Barbara Sternfeld),
For the Women’s Healthy Eating and Living (WHEL) Study Group (Jennifer A. Emond, Loki Natarajan, Lovell Jones, Vicky A. Newman, Cheryl L. Rock, Marcia L. Stefanick, Cynthia A. Thomson, John P. Pierce)
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Old 02-15-2011, 02:01 PM   #2
MJo
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Re: new paper denies increased risk of recurrence w wt gain after diagnosis of Stages

Well thank G-D for that, since I've gained and lost 40 pounds twice since my diagnosis. I'm reading Geneen Roth's "Women, Food and G-d" Some good insights.
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MJO

IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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