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11-28-2007, 09:42 PM
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#21
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Senior Member
Join Date: Aug 2001
Location: Oregon
Posts: 1,756
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AA, here's the article you mentioned in your post on the other thread. I'm kind of confused also, as I thouht that SOME suppression of Cox2 was a good thing. I'm going to look for an article I read some time ago about low-dose aspirin (81 mg) being optimum for that purpose.
Painkillers May Threaten Power of Vaccines
http://vaccines.wordpress.com/2006/1...r-of-vaccines/
Here's some clarification on the ability of aspirin to inhibit Cox1 more than Cox2, therefore preserving the good function of inflammation:
http://en.wikipedia.org/wiki/Aspirin
"...There are at least two different types of cyclooxygenase: COX-1 and COX-2. Aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2...It induces the formation of NO-radicals in the body that enable the white blood cells (leukocytes) to fight infections more effectively. This has been found recently by Dr. Derek W. Gilroy, winning Bayer's International Aspirin Award 2005..."
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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11-28-2007, 11:40 PM
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#22
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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I use to get a flu shot as a kid, then for YRS I never got it. But last yr I decided to get it just before starting chemo and this yr I got the vaccine once again since it is been about 6 months since I finished chemo.
I got it just to be safe.
Harrie
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*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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12-12-2007, 01:36 PM
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#23
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Member
Join Date: Jun 2007
Posts: 10
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Question regarding NSAIDs and BC
Hi Everyone! I read this site frequently, but have not posted before. You are all wonderful inspiration. After reading the links regarding NSAIDs and immune compromised individuals, I'm wondering if I should be taking the NSAID my pc prescribed only 2 wks ago for joint pain. I would rather live with hips that hurt than with the potential for my immune system not to produce antibodies it needs to fight the cancer. Any thoughts anyone?
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12-12-2007, 05:04 PM
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#24
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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I get a flu shot every year and this year I actually got my first pneumonia shot. I ended up with pneumonia but think that if I hadn't had the shot it would have been much worse. I say get the shot - don't take a chance.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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