HonCode

Go Back   HER2 Support Group Forums > Herceptin / Tykerb
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Herceptin / Tykerb Share your experiences or ask questions about Herceptin or Tykerb

Reply
 
Thread Tools Display Modes
Old 10-02-2014, 08:38 PM   #1
Rupali
Senior Member
 
Join Date: Dec 2005
Posts: 148
Does TDM1 cross blood brain barrier

Did anyone of you have TDM1 with metastasis to brain lung liver and bones.
How were the results and how many cycles did it take to get a good result.
Please please reply as tdm1 seems to be my last weapon and we will have to pay a lot from our pocket
Rupali is offline   Reply With Quote
Old 10-03-2014, 06:29 AM   #2
schoonder
Senior Member
 
Join Date: Jul 2008
Posts: 186
Re: Does TDM1 cross blood brain barrier

Recently reported abstract at ESMO re: possible t-dm1 activity in her2+ brain metastases.

https://www.webges.com/cslide/librar...h/6Yy#9faC03oC
schoonder is offline   Reply With Quote
Old 10-11-2016, 01:02 AM   #3
FilY
Member
 
Join Date: Aug 2016
Posts: 5
Re: Does TDM1 cross blood brain barrier

No, TDM1 is a large molecule that does NOT cross the BBB. Thus another technique is needed to prevent brain mets. I recently shifted from Herceptin to TDM1 as a result of what might (not certain) have been early signs of progression. While on Herceptin I was also using Tykerb (lapatinib) which DOES cross the BBB, especially with a pulsed dosing regimen. However Tykerb appears to be incompatible with TDM1 so I'm looking for an alternative. See post of my history and experimental treatment with Tykerb here.
FilY is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -7. The time now is 07:16 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter