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Old 11-17-2010, 06:27 AM   #1
flachica
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Smile Great news - Tykerb/Herceptin/Femara WORKING!!!!
Hi ladies. I posted a few weeks ago - I experienced progression after finishing TCH and then just being on Herceptin and Femara for 3 months. It was in that three months that I experienced progression in the tumors in my liver.

My oncologist thought that because my HER2 signaling pathway was still not being shut down completely by the Herceptin that the Femara didn't even have a chance to work. So she added Tykerb into the mix. Lo and behold - it is working like gangbusters (her favorite word, and now mine). Everything is shrunk in half in 6 weeks. I am thrilled that I can enjoy my holiday season in peace - and I just turned 31 two weeks ago.

I am my doctor's first patient on this particular combo - lots are Herceptin and Femara, but none on Tykerb, Herceptin and Femara - I feel like a trailblazer!! I am just so thankful that it is working!!!
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Old 11-17-2010, 11:18 AM   #2
ElaineM
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Wink Re: Great news - Tykerb/Herceptin/Femara WORKING!!!!
This is wonderful news !! Go ahead and enjoy the holidays with gusto !!
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12 years and counting
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Old 11-17-2010, 11:13 PM   #3
Trish
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Re: Great news - Tykerb/Herceptin/Femara WORKING!!!!
Fantastic news. Keep blazing that trail...and happy birthday.
Trish
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5/2004 (R) 30mm bre gr3 infiltrating ductal ca 16/18nodes er (2+) pr (3+) HER2 (3+)
6/2004 6 cycles(FEC), Oct 40 rads, Tamoxifen
5/2006 oopherectomy, Arimedex
12/2006 liver mets largest 9cm
1/2007 Herceptin,
3/2007 Taxol + Herc
1/2008 Herc alone
4/2008 Multiple bone mets,Zometa
7/2008 Herc + Gemcitabine
8/2008 Herc+Navelbine/vinoralbine
10/2008 Herc+Carboplatin+Taxol
12/2008 Tykerb+Xeloda
2/2010 Herceptin + trial drug
5/2010 Herceptin+Tykerb
8/2010 Tykerb+Abraxane
9/2010 Abraxane
12/2010 Abraxane+Tyk+Herc
4/2011 Tyk+Herc+Femara
6/2011 Liver and bone mets prog.Abraxane continue Herceptin,Tykerb,Femara and Zometa
8/2011 Probable liver progression and increased neuropathy. Xeloda with Tyk+Herc. Zometa 6 weekly.
9/2011 Liver progression,TM +++. Cyclophosphamide and Methotrexate metro Herc Zometa
10/2011 liver mets prog.Herc, 3 Tykerb +2mg decodron daily,Zometa
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Old 11-18-2010, 05:05 AM   #4
whatz
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Re: Great news - Tykerb/Herceptin/Femara WORKING!!!!
what wonderful news :-)! You go girl!
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4/09 suspicious lump in left breast
5/09 biopsi lead to diagnosis ER/PR -
Her2+.Grade 3,full masectomy left breast,sentinel nodes clear,Stage 1
6/09 Adriamycin + Cytoxan 4 treatments (every 3 weeks) followed by Taxol + Herceptin, 1 treatment weekly for 12 weeks, followed by Herceptin for 40 weeks
MRI Brain 4/10 clear
CT Body 4/10 clear
PET Body 2/11 clear
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Old 11-19-2010, 06:38 AM   #5
Yorkiegirl
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Re: Great news - Tykerb/Herceptin/Femara WORKING!!!!
This is really great new's. I'm so happy the combo is working for you. Happy Belated Birthday to you. Wonderful Holiday wishes to you.
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Texas
Biopsy Dx'd 3-23-05 Age 48
MRM 4-5-05 w/ 2 tumor's 5cm, and 6 cm (right side)
IDC (poorly differentiated infiltrating ductual carcinoma)
5+/16 nodes
Stage III A
Grade 3
ER/PR-, Her2/neu ++
Ki67 78%
Begin Chemo 5-2-05 4XAC Dose Dense , 4X Abraxane Dose Dense (ended August 05)
28 Rad's ended October 13 2005
Started Herceptin Weekly August 2005 for one year
Had a Simple mastectomy left side after Mamo showed incresed micro-calcifications. Jan. 17 2006.
Brain MRI Feb.2006--All Clear
August 28, 2006 Last Weekly Herceptin.
October 2006--Colonoscopy, 6 Polyp's removed--all B9
PET Scan July 2007
Abdominal MRI Oct. 2007---2 Right Kidney Cysts
Core Biopsy-- Lump on Scar Line 1-10-08---B9
Brain MRI 6-2008--All Clear
PET/CT Scan 6-2008
Sept. 8 2008, 4CM area removed from mastectomy scar line. Proved to be B9.
PET/CT Scan-- July 2009 --All clear
August 17,2009 ---Had Port Removed
6 Years NED -- April 5,2011
DX'd with Melanoma left arm 10-10-2011
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Old 11-19-2010, 10:16 AM   #6
Ellie F
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Re: Great news - Tykerb/Herceptin/Femara WORKING!!!!
FABULOUS NEWS. Sending lots of positive thoughts from across the pond.

Hugs
Ellie
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Old 12-01-2010, 02:12 PM   #7
flachica
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Re: Great news - Tykerb/Herceptin/Femara WORKING!!!!
Thanks ladies!! I will continue to blaze those trails for as long as I can
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Old 12-02-2010, 02:52 PM   #8
Sandra in GA
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Re: Great news - Tykerb/Herceptin/Femara WORKING!!!!
You are such a beautiful, young warrior! I wish you the very best!
Sandra
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Diagnosed: 7/25/08 ~ age 63, no family history
Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
Vaccine: Walter Reed GP2/AE37 vaccine study ~ last booster 9/17/2012
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