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Old 01-25-2015, 01:19 PM   #1
KDR
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HER-2 Positive & Triple Negative = Cannabis Intervention

Hi, All,
I have been checking in from time to time...things are quite good here.

I just read an article I thought would be of interest in light of the fact patient testimonials are increasingly abundant and positive of the treatment and curative properties of cannabis. It is my fervent hope that cannabis oil, in its proper ratio, will be decriminalized for all those who wish to partake.
And that on a federal level, it will be covered by insurance as a useful tool in the treatment of breast cancer.

We can all look to Stefanie LaRue, who eradicated metastatic cancer from her body with the use of the oil. And thousands of others.

Wishing you all the best 2015, the best year yet,
Love
Karen
__________________
World Trade Center Survivor (56th Floor/North Tower): 14 years and still just like yesterday.
Graves Disease, became Euthyroid via Radioactive Iodine, June 2001.
Thyroid Eye Disease. 2003. Decompression surgery in 2009; eyelid lowering surgery in 2010.
Diagnosed: June 2010, liver mets. ER-/PR+10%; HER2+++.
July 2010: Begin Taxol/Herceptin. Eliminate sugar from diet. No surgery or radiation.
January 2011: NED
April 2011: Progression in liver only. Other previous affected areas eradicated. Stop Taxol/Herceptin after 32 infusions.
May 2011: Brain MRI: clear.
May 2011: Begin Tykerb daily, Xeloda twice per day for one week on, one week off, and Herceptin.
November 2011: Progression in liver. All other tumors remain eradicated.
December 2011: BEGIN TRIAL #09-093 Taxol, MCC-DM1 (T-DM1), Perjeta.
Trial requires scans every six weeks, bloodwork and infusions weekly.
Brain MRI: clear.
January 2012: NED. Liver mets, good riddance!
March 2012: NED. Developed SMA (rare blood clot) in intestinal artery and loss of sight in right eye due to optical nerve neuropathy. Resolved when Taxol removed this month.
Continue Protocol of T-DM1 weekly and Perjeta every 3 weeks.
May 2012: NED.
June 2012: Brain MRI: clear.
June-December 2012: NED.
December 2012: TRIAL CONCLUDED; ENTER TRIAL EXTENSION #09-037. CT, Brain MRI, bone scan: clear. NED.
January-March 2013: NED.
June 2013: Brain MRI: clear. CEA upticking; CT shows new met on liver.
July 3, 2013: DISASTER STRIKES during liver ablation: sloppy surgeon cuts intercostal artery and I bleed out, lose 3.5 liters of blood, have major hemothorax, and collapsed lung requiring emergency resuscitative thoracotomy, lung surgery, rib rearrangement and cutting deep connective tissue, transfusion. Ablation incomplete. This life-saving procedure would end up causing me unforgiving pain with every movement I make, permanently, otherwise known as forever.
July 26, 2013: Try Navelbine/Herceptin. Body too weak after surgery and transfusion. Fever. CEA: Normal.
August 16, 2016: second dose Navelbine/Herceptin; CEA: Normal. Will skip doses. Watching and waiting.
September 2013: NED, Herceptin only. CEA: Normal. Started Arimidex.
October-November 2013: NED. Herceptin and Arimidex. CEA, CA125, 15-3: Normal.
December 2013: Something brewing. PET lights up on little spot on liver; CEA upward trend, just outside normal. PET and triphasic liver scan confirm Little Met. Restart Perjeta with Herceptin, stay on Arimidex. Genomic sequencing completed for future treatments, if necessary.
January 2014: Ablate Little Met on the 6th. Happy New Year.
March 2014: Brain MRI: clear. PET/CT reveal liver mets return; new lung mets. This is not funny.
March 2014: BEGIN TRIAL #10-005 A(11)-Temsirolimus plus Neratinib.
April 2014: Genomic testing indicated they could work, they did not. Very strange drug combo for me, felt weird.
April 2014: Started Navelbine and Herceptin. Needed something tried and true, but had significant progression.
June 2014: Doxil and Herceptin.
July 2014: Progression. Got nothing out of it. Brain: NED.
July 2014: Add integrative medical hematologist-oncologist to my team. Begin supplements. These are tumor-busting, immune system boosters. Add glutathione, lysine and taurine IV infusions every three weeks.
July 2014: Begin Gemzar, Herceptin & Perjeta. Happy.
August 2014: ECHO perfect.
January 2015: Begin weekly Vitamin D Analog infusions. 25 mcg. via port.
February 2015: CT: stable.
April 2015: Gem working, but not 100%. Looking into immunotherapy. Finally, treatments for the 21st century!
April 2015: Penn Medicine. Dendritic cell immunotherapy.
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Old 01-25-2015, 05:49 PM   #2
Ceesun
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Karen, I know someone who takes it for control of a brain tumor. Mentioned this to my onc this past Thurs and asked @ it as it is now sold in health stores in Michigan...he looked upset and told me not to take it. I am not on any chemo at this time. ????
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Old 01-25-2015, 06:08 PM   #3
Jackie07
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

I may have posted this abstract once before ... We all know how long a clinical trial runs ...

Curr Med Chem. 2014 Jun;21(17):1923-30.
Is the clinical use of cannabis by oncology patients advisable?
Bar-Sela G, Avisar A, Batash R, Schaffer M1.
Author information
Abstract
The use of the cannabis plant for various medical indications by cancer patients has been rising significantly in the past few years in several European countries, the US and Israel. The increase in use comes from public demand for the most part, and not due to a scientific basis. Cannabis chemistry is complex, and the isolation and extraction of the active ingredient remain difficult. The active agent in cannabis is unique among psychoactive plant materials, as it contains no nitrogen and, thus, is not an alkaloid. Alongside inconclusive evidence of increased risks of lung and head and neck cancers from prolonged smoking of the plant produce, laboratory evidence of the anti-cancer effects of plant components exists, but with no clinical research in this direction. The beneficial effects of treatment with the plant, or treatment with medicine produced from its components, are related to symptoms of the disease: pain, nausea and vomiting, loss of appetite and weight loss. The clinical evidence of the efficacy of cannabis for these indications is only partial. However, recent scientific data from studies with THC and cannabidiol combinations report the first clinical indication ofcancer-related pain relief. The difficulties of performing research into products that are not medicinal, such as cannabis, have not allowed a true study of the cannabis plant extract although, from the public point of view, such studies are greatly desirable.
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http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

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Old 01-28-2015, 12:18 PM   #4
sarah
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

There are 2 elements in cannibis (maybe more!) one, THC is what makes people stoned and the other is cannabidiol, (I think this is it) and this is what medical people are looking at positively regarding cancer. Obviously most cancer patients don't want to get stoned (ok for pain but not i you're working!) and so they have to separate the helpful element out of it. I read a little about it somewhere but can't remember but it sounded encouraging. We know it's helped people with glaucoma.
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Old 01-29-2015, 02:50 PM   #5
KDR
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Hi, Sarah,
Actually, the higher the THC, the better. I first thought the CBD was most important but it is actually the other way around.
Will start taking it as soon as I can get exactly what I need--
Yours,
Karen
__________________
World Trade Center Survivor (56th Floor/North Tower): 14 years and still just like yesterday.
Graves Disease, became Euthyroid via Radioactive Iodine, June 2001.
Thyroid Eye Disease. 2003. Decompression surgery in 2009; eyelid lowering surgery in 2010.
Diagnosed: June 2010, liver mets. ER-/PR+10%; HER2+++.
July 2010: Begin Taxol/Herceptin. Eliminate sugar from diet. No surgery or radiation.
January 2011: NED
April 2011: Progression in liver only. Other previous affected areas eradicated. Stop Taxol/Herceptin after 32 infusions.
May 2011: Brain MRI: clear.
May 2011: Begin Tykerb daily, Xeloda twice per day for one week on, one week off, and Herceptin.
November 2011: Progression in liver. All other tumors remain eradicated.
December 2011: BEGIN TRIAL #09-093 Taxol, MCC-DM1 (T-DM1), Perjeta.
Trial requires scans every six weeks, bloodwork and infusions weekly.
Brain MRI: clear.
January 2012: NED. Liver mets, good riddance!
March 2012: NED. Developed SMA (rare blood clot) in intestinal artery and loss of sight in right eye due to optical nerve neuropathy. Resolved when Taxol removed this month.
Continue Protocol of T-DM1 weekly and Perjeta every 3 weeks.
May 2012: NED.
June 2012: Brain MRI: clear.
June-December 2012: NED.
December 2012: TRIAL CONCLUDED; ENTER TRIAL EXTENSION #09-037. CT, Brain MRI, bone scan: clear. NED.
January-March 2013: NED.
June 2013: Brain MRI: clear. CEA upticking; CT shows new met on liver.
July 3, 2013: DISASTER STRIKES during liver ablation: sloppy surgeon cuts intercostal artery and I bleed out, lose 3.5 liters of blood, have major hemothorax, and collapsed lung requiring emergency resuscitative thoracotomy, lung surgery, rib rearrangement and cutting deep connective tissue, transfusion. Ablation incomplete. This life-saving procedure would end up causing me unforgiving pain with every movement I make, permanently, otherwise known as forever.
July 26, 2013: Try Navelbine/Herceptin. Body too weak after surgery and transfusion. Fever. CEA: Normal.
August 16, 2016: second dose Navelbine/Herceptin; CEA: Normal. Will skip doses. Watching and waiting.
September 2013: NED, Herceptin only. CEA: Normal. Started Arimidex.
October-November 2013: NED. Herceptin and Arimidex. CEA, CA125, 15-3: Normal.
December 2013: Something brewing. PET lights up on little spot on liver; CEA upward trend, just outside normal. PET and triphasic liver scan confirm Little Met. Restart Perjeta with Herceptin, stay on Arimidex. Genomic sequencing completed for future treatments, if necessary.
January 2014: Ablate Little Met on the 6th. Happy New Year.
March 2014: Brain MRI: clear. PET/CT reveal liver mets return; new lung mets. This is not funny.
March 2014: BEGIN TRIAL #10-005 A(11)-Temsirolimus plus Neratinib.
April 2014: Genomic testing indicated they could work, they did not. Very strange drug combo for me, felt weird.
April 2014: Started Navelbine and Herceptin. Needed something tried and true, but had significant progression.
June 2014: Doxil and Herceptin.
July 2014: Progression. Got nothing out of it. Brain: NED.
July 2014: Add integrative medical hematologist-oncologist to my team. Begin supplements. These are tumor-busting, immune system boosters. Add glutathione, lysine and taurine IV infusions every three weeks.
July 2014: Begin Gemzar, Herceptin & Perjeta. Happy.
August 2014: ECHO perfect.
January 2015: Begin weekly Vitamin D Analog infusions. 25 mcg. via port.
February 2015: CT: stable.
April 2015: Gem working, but not 100%. Looking into immunotherapy. Finally, treatments for the 21st century!
April 2015: Penn Medicine. Dendritic cell immunotherapy.
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Old 01-31-2015, 06:10 AM   #6
sarah
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

ok, well that's interesting! Guess we'll get fat but be happy! Good luck, keep us posted.
be well
sarah
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Old 01-31-2015, 07:45 PM   #7
KDR
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

XOXOXO
Fat? Never, as long as there's yoga and discipline!
How are you all doing there in France?
Karen
__________________
World Trade Center Survivor (56th Floor/North Tower): 14 years and still just like yesterday.
Graves Disease, became Euthyroid via Radioactive Iodine, June 2001.
Thyroid Eye Disease. 2003. Decompression surgery in 2009; eyelid lowering surgery in 2010.
Diagnosed: June 2010, liver mets. ER-/PR+10%; HER2+++.
July 2010: Begin Taxol/Herceptin. Eliminate sugar from diet. No surgery or radiation.
January 2011: NED
April 2011: Progression in liver only. Other previous affected areas eradicated. Stop Taxol/Herceptin after 32 infusions.
May 2011: Brain MRI: clear.
May 2011: Begin Tykerb daily, Xeloda twice per day for one week on, one week off, and Herceptin.
November 2011: Progression in liver. All other tumors remain eradicated.
December 2011: BEGIN TRIAL #09-093 Taxol, MCC-DM1 (T-DM1), Perjeta.
Trial requires scans every six weeks, bloodwork and infusions weekly.
Brain MRI: clear.
January 2012: NED. Liver mets, good riddance!
March 2012: NED. Developed SMA (rare blood clot) in intestinal artery and loss of sight in right eye due to optical nerve neuropathy. Resolved when Taxol removed this month.
Continue Protocol of T-DM1 weekly and Perjeta every 3 weeks.
May 2012: NED.
June 2012: Brain MRI: clear.
June-December 2012: NED.
December 2012: TRIAL CONCLUDED; ENTER TRIAL EXTENSION #09-037. CT, Brain MRI, bone scan: clear. NED.
January-March 2013: NED.
June 2013: Brain MRI: clear. CEA upticking; CT shows new met on liver.
July 3, 2013: DISASTER STRIKES during liver ablation: sloppy surgeon cuts intercostal artery and I bleed out, lose 3.5 liters of blood, have major hemothorax, and collapsed lung requiring emergency resuscitative thoracotomy, lung surgery, rib rearrangement and cutting deep connective tissue, transfusion. Ablation incomplete. This life-saving procedure would end up causing me unforgiving pain with every movement I make, permanently, otherwise known as forever.
July 26, 2013: Try Navelbine/Herceptin. Body too weak after surgery and transfusion. Fever. CEA: Normal.
August 16, 2016: second dose Navelbine/Herceptin; CEA: Normal. Will skip doses. Watching and waiting.
September 2013: NED, Herceptin only. CEA: Normal. Started Arimidex.
October-November 2013: NED. Herceptin and Arimidex. CEA, CA125, 15-3: Normal.
December 2013: Something brewing. PET lights up on little spot on liver; CEA upward trend, just outside normal. PET and triphasic liver scan confirm Little Met. Restart Perjeta with Herceptin, stay on Arimidex. Genomic sequencing completed for future treatments, if necessary.
January 2014: Ablate Little Met on the 6th. Happy New Year.
March 2014: Brain MRI: clear. PET/CT reveal liver mets return; new lung mets. This is not funny.
March 2014: BEGIN TRIAL #10-005 A(11)-Temsirolimus plus Neratinib.
April 2014: Genomic testing indicated they could work, they did not. Very strange drug combo for me, felt weird.
April 2014: Started Navelbine and Herceptin. Needed something tried and true, but had significant progression.
June 2014: Doxil and Herceptin.
July 2014: Progression. Got nothing out of it. Brain: NED.
July 2014: Add integrative medical hematologist-oncologist to my team. Begin supplements. These are tumor-busting, immune system boosters. Add glutathione, lysine and taurine IV infusions every three weeks.
July 2014: Begin Gemzar, Herceptin & Perjeta. Happy.
August 2014: ECHO perfect.
January 2015: Begin weekly Vitamin D Analog infusions. 25 mcg. via port.
February 2015: CT: stable.
April 2015: Gem working, but not 100%. Looking into immunotherapy. Finally, treatments for the 21st century!
April 2015: Penn Medicine. Dendritic cell immunotherapy.
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Old 01-31-2015, 07:51 PM   #8
Nurse4u2day
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Unfortunately as a nurse I often get drug tested as well as in the state of California even though I can get a marijuana card , I would lose my nursing license if I got a card .
And I'm a non smoker ( virgin lungs here) but I do love brownies lol.
Now of course if you told me this could save my life I might just have to retire at the ripe age of 46
__________________
]11/13 Dx IDC left breast
11/19/2013 Inflammatory Breast Cancer stage 3c grade 2 Er- Pr- her2+++
Node involvement suspected based on CT
12/13 port placed
12/13 neoadjuvant DD AC xs 4 rounds started
02/14 taxol/herceptin started every week xs 12 rounds
Herceptin for 1 year
Ki67=23%
BRCA1&2 negative
5/06/14 last round taxol/herceptin. Chemo done!!!
5/07/14 clear CT scan
6/11/14 Bilateral Mastectomy Done
6/15/14 8mm tumor post chemo. Removed by bmx
6/15/14 lymph nodes 0/9
6/15/14 officially Cancer Free
7/11/14 emergency surgery to left breast . Wound refused to heal and broke open. New TE placed
7/28/14 emergency medical procedure now to right breast( post op 6 weeks mastectomy ) wound opens.
8/25/14 - 10/07/14 Radiation
11/24/14 CT of Brain clear
01/23/15 One year Herceptin Complete
02/04/15 Diep done
5/01/15 1 year Ct scan- mass in thymus
6/23/15 repeat CT mass in thymus still present
6/30/15 biopsy thymus 7/03/15 mass Benign! Diagnoses Thymic hyperplasia rebound ( chemo at fault, no long term health effects)
7/08/15 phase 2 diep
11/23/15 phase 2b ( reconstructive surgery with lipo)
03/05/18 Vinnie Myer 3 D nipple tattoos complete.
11/19/2018 5 years since Dx of IBC stage 3c remain NED.
11/19/21- 8 years today I officially remain NED and in 12 days I will be having a lymphnode transfer to help decrease some mild lymphedema! Still working, living life and soon to see a day I thought never would happen and that’s becoming a grandparent June 22nd.
11/19/2023 - 10 years since diagnosis and I remain NED
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Old 02-03-2015, 12:40 PM   #9
Stellasmom
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

I'm incredibly lucky to live in Washington state for our amazing oncologist and reaearchers, as well as legal cannabis. I have my medical card and basically everything you can think of for THC or CBD treatment, I can get at a reasonable price. I have CBD pills and a oil, as well as edibles that are made in professional kitchens. I can't tell you if they are shrinking my tumor... I'm sure it's the herceptin, but it does help with appetite and to relax. I talked to my oncologist about it and she said she can't tell me if it works or not to treat the growth, but she said I'm welcome to use it however I want.

I wish you all had it available to you!
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Old 02-04-2015, 01:14 PM   #10
lkc Gumby
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

It's all very interesting and I think we'll see a progression of using cannabis more in the future.
For Nurse4u2day: had to smile at your comments. BTW: My dx was Stage IIIC , er/pr neg, Her2 positive also and am a nurse as well. Dxed 10 years this May, NED since that time
__________________
Linda

Dxed Stage IIIC May 05, 12 pos nodes
er/pr -neg,Her -pos
LVI
Right partial mast & partial axillary dissection-June14,2005
Right modified mast-no clear margins- June 30, 2005
DD AC x4
Taxotere X4 with Herceptin
Rads x 35( 5 fields )
Left prophylactive mast( atypia & hyperplasia found ),
put on Tamoxifen x 1 yr; D/ced due to endometrial thickening
bilateral recon (saline implants)May 06
Nipple recon July 06
metformin 2010
removal of implants due to severe encapsulation, insertion of gummies 2013
Reclast Q yr
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Old 02-08-2015, 12:16 PM   #11
Cal-Gal
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Hello KDR and all,

I have been off the site for awhile. I too am very interested in the use of cannabis to treat and cure cancer.

I have read some articles and watched a few you tubes.
KDR-you mentioned an article I did not see a link?
Has anyone heard of Cannabis International?

What has me jump back on the site is after 6 years, I found a lump-pea type in my right-side (different side from cancer) scar line about 10 days ago-ultrasound indicates solid not fluid filled and I am having a biopsy this Wednesday.

Hugs!!
__________________
DX: 11/08 Age: 53
Surgery: 1/09
Bilat Mastectomy, no reconstruction
ILC-4 tumors-1.7 cm,1.5 cm (2).8 cm
DCIS-11 cm
All tumors Grade 3
All tumors ER-0%/PR-0%
All tumors HER2+
IHC-all tumors Overexpression/borderline
FISH 2 tumors Her2-Negative
FISH 2 tumors Her2+ Equivocal
Stage I, 0/1 nodes
LVI-Indeterminate(treated as positive)
SPR Score 8/9
Ki-67 20%
BRCA genetic test 1/2=negative
Chemo: 6 rounds TAC Feb-June 2009 w/Neulasta
Herceptin: 6/12/09-6/4/10 52weeks
HNPCC genetic test: negative
Port Placement-9/23/09 Port Removal 6/25/10
Echo's every 3 months-All normal
2/09 Staging PET/CT showed 0.2 micronodule upper R lobe-lung-Onc does not think this is mets--
6/5/09 AND 10/09 CT scan 0.2 micronodule unchanged
1/10-PET/CT-uptake in nasopharynx-
1/10-MRI All normal
6/10-Bone Scan-clear
12/10-PET/CT-All Clear-NED
12/11-PET-All Clear-NED

12/12-PET-All Clear-NED
12/13-CT w/contrast Head, Torso-All Clear
12/14-CT w/contrast Head-All Clear
2/15-Core needle biopsy-R scar line

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Old 02-08-2015, 07:09 PM   #12
KDR
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Cal-Gal,
I didn't make note of that article, sorry. There are so many available.
Hoping for the bet for you,
Karen
__________________
World Trade Center Survivor (56th Floor/North Tower): 14 years and still just like yesterday.
Graves Disease, became Euthyroid via Radioactive Iodine, June 2001.
Thyroid Eye Disease. 2003. Decompression surgery in 2009; eyelid lowering surgery in 2010.
Diagnosed: June 2010, liver mets. ER-/PR+10%; HER2+++.
July 2010: Begin Taxol/Herceptin. Eliminate sugar from diet. No surgery or radiation.
January 2011: NED
April 2011: Progression in liver only. Other previous affected areas eradicated. Stop Taxol/Herceptin after 32 infusions.
May 2011: Brain MRI: clear.
May 2011: Begin Tykerb daily, Xeloda twice per day for one week on, one week off, and Herceptin.
November 2011: Progression in liver. All other tumors remain eradicated.
December 2011: BEGIN TRIAL #09-093 Taxol, MCC-DM1 (T-DM1), Perjeta.
Trial requires scans every six weeks, bloodwork and infusions weekly.
Brain MRI: clear.
January 2012: NED. Liver mets, good riddance!
March 2012: NED. Developed SMA (rare blood clot) in intestinal artery and loss of sight in right eye due to optical nerve neuropathy. Resolved when Taxol removed this month.
Continue Protocol of T-DM1 weekly and Perjeta every 3 weeks.
May 2012: NED.
June 2012: Brain MRI: clear.
June-December 2012: NED.
December 2012: TRIAL CONCLUDED; ENTER TRIAL EXTENSION #09-037. CT, Brain MRI, bone scan: clear. NED.
January-March 2013: NED.
June 2013: Brain MRI: clear. CEA upticking; CT shows new met on liver.
July 3, 2013: DISASTER STRIKES during liver ablation: sloppy surgeon cuts intercostal artery and I bleed out, lose 3.5 liters of blood, have major hemothorax, and collapsed lung requiring emergency resuscitative thoracotomy, lung surgery, rib rearrangement and cutting deep connective tissue, transfusion. Ablation incomplete. This life-saving procedure would end up causing me unforgiving pain with every movement I make, permanently, otherwise known as forever.
July 26, 2013: Try Navelbine/Herceptin. Body too weak after surgery and transfusion. Fever. CEA: Normal.
August 16, 2016: second dose Navelbine/Herceptin; CEA: Normal. Will skip doses. Watching and waiting.
September 2013: NED, Herceptin only. CEA: Normal. Started Arimidex.
October-November 2013: NED. Herceptin and Arimidex. CEA, CA125, 15-3: Normal.
December 2013: Something brewing. PET lights up on little spot on liver; CEA upward trend, just outside normal. PET and triphasic liver scan confirm Little Met. Restart Perjeta with Herceptin, stay on Arimidex. Genomic sequencing completed for future treatments, if necessary.
January 2014: Ablate Little Met on the 6th. Happy New Year.
March 2014: Brain MRI: clear. PET/CT reveal liver mets return; new lung mets. This is not funny.
March 2014: BEGIN TRIAL #10-005 A(11)-Temsirolimus plus Neratinib.
April 2014: Genomic testing indicated they could work, they did not. Very strange drug combo for me, felt weird.
April 2014: Started Navelbine and Herceptin. Needed something tried and true, but had significant progression.
June 2014: Doxil and Herceptin.
July 2014: Progression. Got nothing out of it. Brain: NED.
July 2014: Add integrative medical hematologist-oncologist to my team. Begin supplements. These are tumor-busting, immune system boosters. Add glutathione, lysine and taurine IV infusions every three weeks.
July 2014: Begin Gemzar, Herceptin & Perjeta. Happy.
August 2014: ECHO perfect.
January 2015: Begin weekly Vitamin D Analog infusions. 25 mcg. via port.
February 2015: CT: stable.
April 2015: Gem working, but not 100%. Looking into immunotherapy. Finally, treatments for the 21st century!
April 2015: Penn Medicine. Dendritic cell immunotherapy.
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Old 02-08-2015, 07:58 PM   #13
Cal-Gal
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Thanks Karen!
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DX: 11/08 Age: 53
Surgery: 1/09
Bilat Mastectomy, no reconstruction
ILC-4 tumors-1.7 cm,1.5 cm (2).8 cm
DCIS-11 cm
All tumors Grade 3
All tumors ER-0%/PR-0%
All tumors HER2+
IHC-all tumors Overexpression/borderline
FISH 2 tumors Her2-Negative
FISH 2 tumors Her2+ Equivocal
Stage I, 0/1 nodes
LVI-Indeterminate(treated as positive)
SPR Score 8/9
Ki-67 20%
BRCA genetic test 1/2=negative
Chemo: 6 rounds TAC Feb-June 2009 w/Neulasta
Herceptin: 6/12/09-6/4/10 52weeks
HNPCC genetic test: negative
Port Placement-9/23/09 Port Removal 6/25/10
Echo's every 3 months-All normal
2/09 Staging PET/CT showed 0.2 micronodule upper R lobe-lung-Onc does not think this is mets--
6/5/09 AND 10/09 CT scan 0.2 micronodule unchanged
1/10-PET/CT-uptake in nasopharynx-
1/10-MRI All normal
6/10-Bone Scan-clear
12/10-PET/CT-All Clear-NED
12/11-PET-All Clear-NED

12/12-PET-All Clear-NED
12/13-CT w/contrast Head, Torso-All Clear
12/14-CT w/contrast Head-All Clear
2/15-Core needle biopsy-R scar line

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Old 02-10-2015, 05:23 PM   #14
IrvineFriend
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Too bad its the THC that is the active ingredient. Only because I did use pot during my last round of chemo and it was truly a godsend. I live in CA where its legal for medicinal purposes but also have the restrictions job-wise that it's still a federal offense. When I was going through chemo I could give a rip if it became a legal issue. 35 lb weight loss and I wasn't heavy to begin with and very, very sick in the end. But the feeling stoned was an issue. No way I could work using it regularly. I took a puff at night so I could eat. My experience is that it would be hard to still work. I've taken THC via pill and still had that stoned feeling. If they could find a way to deliver it and still be productive, all for it.
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Julie
Live in Orange County, CA

Diagnosed with DCIS Oct. 2012

Bilateral Dec. 19, 2012
IDC, ER/PR-, Her2+++, Grade 3
Stage IIIa
15.6 cm
4/14 nodes + macrometastases
First thing each morning, I try on my bathing suit. Then, nothing worse can happen the rest of the day.
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Old 02-14-2015, 07:54 PM   #15
KDR
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Found the article I read before posting:
http://www.truthonpot.com/2013/03/09...ancer-therapy/


All the best, to all, always,
Karen
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Old 03-16-2015, 05:17 PM   #16
Donna
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Hi Amazing Group,

I found this topic interesting, didn't expect to take it too seriously and then I found this:
http://www.cancer.gov/cancertopics/p.../page4#_26_toc

Wow! This is totally legitimate and looks so efficacious, why isn't there more out there about it?????

Donna
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Donna in the Sierra Foothills of California

Diagnosed 6/7/06 invasive ductal carcinoma/ductal carcinoma in situ
Lumpectomy 6/21/06
Pathology: Er 99% Pr 10% Her2/neu 3+
DNA Index 1.0
S-Phase 3/High
Primary Tumor 2.4 cm Sentinel Node Tumor 2.1cm
A/C/T+ Herceptin + rads + Arimidex
stopped Herceptin after 7 mos. due to low MUGA
Surgery for thickened uterine tissue May 2008 - conclusion: side effect of Arimidex
Switched from Arimidex to Femara - joint/tendon problems significantly better!
2 year mark Pet scan and Echo shows all clear!
5 year mammogram with ultrasound shows no sign of cancer - yay!
11 years, 11 months new breast cancer - found lump
Mastectomy 4/30/2018
Pathology: Er99%, PR 28%, Her2 negative! (new type)
Faslodex
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Old 03-17-2015, 12:56 AM   #17
sarah
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Hi Karen,
France is still great. Look me up if you ever get near the Cannes area.
Glad to see people are taking it in pill form not smoking it. smoking would always effect the lungs negatively. Good then that the US is legalizing it.
Julie, I haven't been taking pot but I can tell you, I couldn't have worked during chemo! I was flat on my back and consequently gained 15lbs! Taxol, Herceptin for 6 months, once a week and the anti-allergy drug they gave me made me stoned! The US is fairly puritanical so I would doubt there is any "high" in the medical version!
Be well all of you
A+ as they say here
sarah
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Old 03-31-2015, 01:18 PM   #18
Rosalie
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

This is an area my sister and I are excited about! From what we've understood, it's important for the oil (you have to eat the oil not smoke it) to have near equal amounts of THC and CBD.

There's a phase 2 trial about to start in Israel testing the effects of cannabinoids on cancer in humans: https://clinicaltrials.gov/ct2/show/...&sel_rss=mod14

Here’s all of the other research I know about.

Breast-cancer specific:

August 2011 research from Dr. Sean McAllister on cannabidiol (CBD) inhibiting the spread of breast cancer.
http://www.medscape.com/medline/abstract/20859676
(More on McAllister and his research here.)

A 2010 study on cannabinoids specifically targeting her2
http://www.molecular-cancer.com/content/9/1/196#B4

A February 2006 study found anandamide (a cannabinoid neurotransmitter) inhibited the spread of breast cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/16343481

A 2011 study on the effect of cannabinoid on chemokine receptor CXCR4: http://www.ncbi.nlm.nih.gov/pubmed/2...?dopt=Abstract

2007 research by McAllister and Desprez -Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cell
http://www.ncbi.nlm.nih.gov/pubmed/18025276


Specific to other cancers:

1974 University of Virginia study found that tetrahydrocannabinol (THC) slowed Lewis lung adenocarcinoma and leukemia growth in a dose-dependent relationship: http://www.ncbi.nlm.nih.gov/pubmed?c...t_uids=1159836

1998 study from Dr. Manuel Guzmán showed THC induced apoptosis in glioma cells: http://www.ncbi.nlm.nih.gov/pubmed/9771884

A 2006 study by Dr. Manuel Guzmán found that THC could induce apoptosis in multiple pancreatic cancer cell lines: http://cancerres.aacrjournals.org/co...6/13/6748.full

A 2007 Harvard Study demonstrated THC inhibited multiple non-small cell lung cancer lines and reduced tumor weight and volume in mice by 50%.
http://www.ncbi.nlm.nih.gov/pubmed/21097714

A 2003 study showed activation of cannabinoid receptors induced skin cancer cell death: http://www.jci.org/articles/view/16116

1999 study in FEBS Letters found THC induced apoptosis in the PC3 line of prostate cancer: http://www.ncbi.nlm.nih.gov/pubmed/10570948

A 2011 study of the effects of THC on apoptosis in prostrate cancer.
http://www.ncbi.nlm.nih.gov/pubmed/22110202

June 2003 study demonstrated anandamide (a cannabinoid neurotransmitter) induced apoptosis in multiple prostate cancer cell lines.
http://www.ncbi.nlm.nih.gov/pubmed/12746841

October 2013 research at the University of London, St. Georges, showed that cannabinoids could kill leukemia cells.
http://ar.iiarjournals.org/content/3...ract#corresp-1

November 2013 study published in Case Reports in Oncology offers proof that cannabis extracts may be able to kill cancer in a human body.
http://www.karger.com/Article/FullText/356446

A November 2006 study found that liver cancer patients with higher expressions of CB1 and CB2 cannabinoid receptors had much better disease-free survival than patients with lower expressions.
http://www.ncbi.nlm.nih.gov/pubmed/17074588

November 2014 study showing that cannabinoids CBD and THC could shrink aggressive brain cancer.
http://mct.aacrjournals.org/content/...-0402.abstract
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Old 03-31-2015, 02:00 PM   #19
KDR
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

Rosalie,
Thank you for sharing your research. Israel, Spain, why not US?

Karen
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Old 04-03-2015, 10:48 PM   #20
linn65
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Re: HER-2 Positive & Triple Negative = Cannabis Intervention

I have smoked pot but it makes me paranoid, so I don't really like it. BUT if it would
Cure me or make my body feel better I would smoke it, eat it, or drink it. ��. I wish I knew more.
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myleftlump.wordpress.com - started blogging my
IDC breast cancer
7/2012 diagnosed with multiple solid lesions
7/20/12 biopsy done. ER+ 30 PR -, HER+++,k167 80% Grade 2
9/2012 biopsy on lymph node - showed malignant

9/2012 Pre-adjunctive TCH chemo.

12/6/12 MRI after Pre-adj.
Results: Modest Decrease in size of left breast malignancy As well as the associated satellite lesions and auxiliary Adenopathy compared to prior study. Doctors hoped for better but good response it didn't grow.

12/18/2012 left masectomy with axillary nodes
Size 3.2 CM, Nottingham score 9/9
Grade 3, no evidence of in situ carcinoma
Areas of angiolymphatic are identified
Carcinoma is 0.5 cm from inked deep
Margin of excision
Attached axillary lymph nodes: metastatic
Carcinoma in 6 of 8 nodes.
Size of largest node 1.5 cm
Extracapsular
ER + 73%, PR+2%, HER2+

2/27/13 6 weeks of IMRT radiation finished

2/2013 Started on Tamoxifan 5 years.

8/2013 will take last Herceptin, 17 treatments total every 3 weeks.

BRCA1 & BRAC2 - Negative

August 28, 2013 DIEP flap on the left breast.
February 2014 Nip & Tuck
March 14, 2014 nipple reconstruction and removed port.
August 14, 2014 lump in lymph nodes under arm and above clavicle. Stage IV
August 28, 2014 herceptin And projeta starting and port put back in.

3/18/15 stopped arimidex.
3/18/15 progression....Tdm1
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