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11-30-2011, 07:31 AM
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#1
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Senior Member
Join Date: Jul 2006
Posts: 463
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Experience with Pertuzumab?
Hi all, it looks like Pertuzumab is going to be one of the news-makers at SABCS next week. I haven't heard much about it here, but maybe I just haven't been paying attention. Is anyone in a Pertuzumab trial (or have you been in one previously)? If so, how's it going (or how did it go)? I'm more curious to hear real-person reports of side effects than of efficacy -- the study reports will, as always, emphasize the efficacy.
I look forward to seeing others in San Antonio next week, and to hearing something new and impressive. I'm getting a little jaded about SABCS these last few years -- not enough progress, not fast enough either. If they try to rehash ATAC again, for one example, I'm going to scream.
But it is still amazing to be there, to see the brilliance and energy that is being devoted to stopping breast cancer. And to meet up with all the wonderful friends that have come into my life because of breast cancer.
Debbie Laxague
__________________
3/01 ~ Age 49. Occult primary announced by large (6cm) axillary node, found by my husband.
4/01 ~ Bilateral mastectomies (LMRM, R elective simple) - 1.2cm IDC was found at pathology. 5 of 11 axillary nodes positive, largest = 6cm. Stage IIIA
ERPR 5%/1% (re-done later at Baylor, both negative at zero).
HER2neu positive by IHC and FISH (8.89).
Lymphovascular invasion, grade 3, 8/9 modified SBR.
TX: Control of arm of NSABP's B-31 adjuvant Herceptin trial (no Herceptin, inducing a severe case of Herceptin-envy): A/C x 4 and Taxol x 4 q3weeks, then rads. Raging infection of entire chest after small revision of mastectomy scar after completing tx (significance unknown). Arimidex for two years, stopped after second pathology opinion.
2017: Mild and manageable lymphedema and some cognitive issues.
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11-30-2011, 06:48 PM
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#2
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Re: Experience with Pertuzumab?
Debbie, I'm with you - progress is too slow - but reporting out 2 Pertuzumab trials on Friday should be exciting news. I've not heard much about the side effects...but do know that there is much anticipation and excitement over it. I'm looking forward to seeing it and more importantly, finding out how close they will be to filing for approval!
Maybe I'll see you there.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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12-01-2011, 03:22 AM
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#3
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Senior Member
Join Date: Feb 2009
Posts: 1,526
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Re: Experience with Pertuzumab?
Just want to say thank you to my sisters going to San Antonio.I always await the latest news in our fight against the beast and hope this year brings us some stellar good news on more targeted treatments.
Looking forward to the posts!
Ellie
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12-01-2011, 06:48 AM
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#4
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Senior Member
Join Date: Jan 2008
Location: Evergreen, Colorado
Posts: 454
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Re: Experience with Pertuzumab?
Debbie,
Thank you for starting this thread. I am very anxious to hear about the status of Pertuzumab. My onc has expressed excitement about this possibility, yet when I try to gain insights she doesn't seem to have many specifics for me.
Chrisy and all attending SABCS...thank you so much for going. It would be great if you guys could get the scoop on FDA approval status. My internet searches indicated that back in the summer and fall things were moving forward for approval. Then all goes radio silent. So if you could get a sense of timing that would be great!!
OK...getting greedy here.....the only trials I saw paired Pertuzumab with Doxil. I had hoped for a very targeted option of Herceptin + Pertuzumab. It would be wonderful if you could get a sense of what the potential cocktail might look like.
Exciting stuff for sure and as everyone knows, looking for another option for my hip pocket.
Again, thank you to all your brainiacs attending SABCS. I am thrilled to have the inside track on these options. My onc has come to respect my insights based on all I learn from this site.
__________________
2007
Oct - Diagnosed - Stage IV 5 c.m. IDC - Left Side er/pr- Her2+++ Node + 2/14 - Single Liver Met Double Mastectomy Nov - Begin T+H 2008
Feb-Complete 6 cycles- T&H- NED
March - Continue - Herceptin Only
April - Rads for 6 weeks
2009
Continue Herceptin - Continue NED
April - Recurrance- 3 cm. Liver Met
May - Cryosurgery
June - November - Abraxane + Herceptin
Aug - PET/CT - CTC = 0 Back to NED
2010
January - Continue NED
July - Recurrance - 3 cm Liver Met CTC=1
August - Cryosurgery #2
August - November Navelbine
November - Back to NED - End Navelbine
2011
Feb - Recur - 4 cm Liver Met - Same Left Lobe
March Surgery it is -Couldn't get a clean margin
July - Confirmed continued liver involvement
August - Begin Herceptin + Tykerb
October - Mixed results from H+T
Add Abraxane + H + T - Nov - April
2012
January PET Scan - It's working!!
April - Back to NED
July - Recurrance
August - Begin TDM-1 Trial (Taxol + TDM-1)
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12-01-2011, 04:24 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Re: Experience with Pertuzumab?
I know that 2 studies will be reported out in the main session at SABCS on Friday am. Genentech is also having a small group meeting (which will include at least myself, Brenda and StephN) at which time questions about WHEN this will be submitted for FDA approval will certainly be asked, and hopefully answered...
Many people I've spoken with (Genentech researchers as well as oncologists) are very excited about this.
I just hope everyone hurries up!
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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12-01-2011, 11:30 PM
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#6
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Senior Member
Join Date: Jan 2009
Location: Colorado Springs, CO
Posts: 430
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Re: Experience with Pertuzumab?
Article about Genentech's upcoming announcements at SABCS:
http://www.xconomy.com/san-francisco...ncer-confab/2/
__________________
9/15/08 (age 52) - Mammo: calcifications
9/22/08 - Biopsy: DCIS, grade 3. ER,PR status: Pos. in 75-90% of tumor cells.
10/01/08 - Ob/Gyn appt.: found complex, mostly cystic mass on right ovary - 11cmx12cmx 8cm
10/15/08 - Hysterectomy & Oophorectomy, Lumpectomy: Cyst on uterus, not ovary - all was benign. Breast - 5 of 6 bad margins. 2 Sentinel Lymph nodes removed, both negative. Stage 0, Tis, N0
12/11/08 - Mastectomy & DIEP reconstruction: Surprise! 2 cm Invasive DC, grade 2 found. One benign internal mammary lymph node. Stage 1, T1c, N0, all clean margins. ER+ (Proportion Score = 2/5, Intensity Score = 2/3) and PR+(Proportion Score = 3/5, Intensity Score = 2/3)
HER2 score = 3+
1/09/09 - Oncotype DX: Recurrence S/core of 60 !?!?! ER status is NEG!! PR staus is NEG! HER2 score = 12.2 (still positive, greater than 11.5 is positive).
1/20/09 - Started chemo: TCH
5/26/09 - FINISHED CHEMO!
1/05/10 - FINISHED HERCEPTIN!
1/22/10 - Port-a-catheter removed!
3/07/18 - Still NED
9/10/23 - Still NED
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