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Old 10-29-2013, 11:18 AM   #1
'lizbeth
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Post MM-302 with Advanced Breast Cancer

Safety and Pharmacokinetic Study of MM-302 in Patients With Advanced Breast Cancer

NCT01304797
This study is a Phase 1 and pharmacologic open-label dose-escalation trial using a "3+3" design. Successive cohorts of three or more patients will be treated at escalating doses until a maximum tolerated dose is identified. Once the maximum tolerated dose is identified, an Expansion Cohort will be enrolled at that dose to further characterize safety and pharmacologic endpoints. Additional arms will be enrolled to explore the combination of MM-302 with trastuzumab or trastuzumab plus cyclophosphamide in patients with advanced HER2 positive breast cancer


http://www.clinicaltrials.gov/ct2/sh...=MM-302&rank=1
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Old 10-29-2013, 12:40 PM   #2
donocco
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Re: MM-302 with Advanced Breast Cancer

I dont know if this is repetitive info but I did some quick
research on the drug. MM302 is a liposomal form of Doxorubicin (Adriamycin). The fatty liposome particles are coated with anti Her2neu protein particles, so the liposomes containing the Adriamycin go straight to the Her2Neu carrying breast cancer cells. Once inside the cancer cells, the liposome breaks up and the Adriamycin is released in the cancer cells hopefully killing it. The idea is to avoid the heart toxicity of Doxorubicin (Adriamycin) as the muscle cells in the heart have low levels of Her2Neu protein.

A possible dose might be 40mg per square meter once every 4 weeks. The main side effects seem to be constipation (53%), fatigue (69%) and decreased appetite (46%). Interestingly there was no mention of hand-foot syndrome (so far) which is a main side effect of Doxyl, the FDA approved liposomal Doxorubicin. Doxyl liposomes are not coated with anti-Her2Neu antibody and are less cancer cell specific.

Hope this helps a bit.

Paul
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Old 10-29-2013, 01:05 PM   #3
StephN
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Re: MM-302 with Advanced Breast Cancer

Hey Paul!
Nice to see you and your helpful info here.
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and half of 2017. Boring ...
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Old 10-29-2013, 02:08 PM   #4
'lizbeth
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Re: MM-302 with Advanced Breast Cancer

I love how this works. I find something interesting and post it. Then Paul pops up and explains it. Awesome.
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Old 02-18-2014, 02:28 PM   #5
Krysti
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Re: MM-302 with Advanced Breast Cancer

I am on this trial - Arm 4 with cyclophosphamide/Herceptin/MM-302. Only second round, but doing well and excited about more Adriamycin as it worked well for me 9 years ago when I was first diagnosed out of the gate stage IV. I have had lung and 11 brain mets. Excited about the way it works, the drug delivery (like TDM-1 trial I was on) and that there is preliminary evidence by attaching a tracer to the drug that it goes to bone and brain (especially important in my case with 4 years of brain mets)...I will update and let you know how it goes!
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Old 02-18-2014, 07:42 PM   #6
'lizbeth
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Re: MM-302 with Advanced Breast Cancer

Krysti,

Thank you for enrolling. I wish you the best. Keep us posted!
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