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02-04-2008, 05:54 PM
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#1
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Senior Member
Join Date: Oct 2007
Posts: 203
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Top2a
I was wondering if anyone has had their TOP2A tested ala this news that the test was approved by the FDA?
I showed the article to my onc., and he said he didn't think it would give us any new information (I've already been treated). It looks like the test is meant to predict responsiveness to chemo, and predict odds of recurrence (which is my obsession, despite knowing that my individual odds are either 0% or 100%).
http://patient.cancerconsultants.com...,FISH,pharmaDx
I searched the archives and saw one study that suggested that TOP2A overexpression was correlated with HER2+ overexpression.
Thanks.
Rebecca
__________________
Dx 8/06 Age 43 Stage IIIA multifocal throughout breast, largest tumor 5 cm, grade 3, comedo, ER+PR+HER+++
Neoadjuvant A/C 4X Dose Dense
11/06 Bilateral Mastectomy (no choice on the right, my choice on the left)
Taxol+Herceptin weekly x12, continuing with Herceptin, finished one year in 12/07
33 Rads
Femara for 5+ years, staying on (started with Arimidex, switched after about a month, much happier)
Abnormal brain MRI shows no cancer, but "extensive white matter diease" - unknown cause
BRCA negative - lots of cancer in my family
survivor of thyroid cancer
also have Crohn's disease
CT and bone scan say NED as of 5/13
dx with severe cardiomyopathy 5/12 (likely due to chemo and Herceptin), ejection fraction in low 20's, now up to 40, went to 50, latest read 12/13 is back down to 35
1/13 Acute pancreatitis - are you kidding me?
9/13 started Humira for Crohn's. starting to have some energy again
B12 and Vit D both needed supplementation
Cataracts in both eyes noted 6/12 - surgery in the next 2-4 years?
4/14 Kidney stones/blockage/infection - related to Crohn's Disease
5/14 My aunt passed away - she was diagnosed after I was with Stage I - not Her2+, then Stage 4 for about one year
6/14 Scans - still NED, thank God. However, broken rib (I didn't notice) lots of bone degeneration osteopenia/osteoporosis. I also still have cardiomyopathy secondary to chemo.
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02-05-2008, 08:22 PM
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#2
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Senior Member
Join Date: Oct 2007
Posts: 203
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bumping up - anyone?
__________________
Dx 8/06 Age 43 Stage IIIA multifocal throughout breast, largest tumor 5 cm, grade 3, comedo, ER+PR+HER+++
Neoadjuvant A/C 4X Dose Dense
11/06 Bilateral Mastectomy (no choice on the right, my choice on the left)
Taxol+Herceptin weekly x12, continuing with Herceptin, finished one year in 12/07
33 Rads
Femara for 5+ years, staying on (started with Arimidex, switched after about a month, much happier)
Abnormal brain MRI shows no cancer, but "extensive white matter diease" - unknown cause
BRCA negative - lots of cancer in my family
survivor of thyroid cancer
also have Crohn's disease
CT and bone scan say NED as of 5/13
dx with severe cardiomyopathy 5/12 (likely due to chemo and Herceptin), ejection fraction in low 20's, now up to 40, went to 50, latest read 12/13 is back down to 35
1/13 Acute pancreatitis - are you kidding me?
9/13 started Humira for Crohn's. starting to have some energy again
B12 and Vit D both needed supplementation
Cataracts in both eyes noted 6/12 - surgery in the next 2-4 years?
4/14 Kidney stones/blockage/infection - related to Crohn's Disease
5/14 My aunt passed away - she was diagnosed after I was with Stage I - not Her2+, then Stage 4 for about one year
6/14 Scans - still NED, thank God. However, broken rib (I didn't notice) lots of bone degeneration osteopenia/osteoporosis. I also still have cardiomyopathy secondary to chemo.
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02-05-2008, 09:19 PM
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#3
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Senior Member
Join Date: Sep 2005
Posts: 232
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Do you mean the Topo II test? If so, I know that Jean had the test and I think a couple of other gals did, too.
Karen
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02-05-2008, 09:21 PM
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#4
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Senior Member
Join Date: Oct 2007
Posts: 203
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I guess so - can you tell me more about that? Thanks.
Rebecca
__________________
Dx 8/06 Age 43 Stage IIIA multifocal throughout breast, largest tumor 5 cm, grade 3, comedo, ER+PR+HER+++
Neoadjuvant A/C 4X Dose Dense
11/06 Bilateral Mastectomy (no choice on the right, my choice on the left)
Taxol+Herceptin weekly x12, continuing with Herceptin, finished one year in 12/07
33 Rads
Femara for 5+ years, staying on (started with Arimidex, switched after about a month, much happier)
Abnormal brain MRI shows no cancer, but "extensive white matter diease" - unknown cause
BRCA negative - lots of cancer in my family
survivor of thyroid cancer
also have Crohn's disease
CT and bone scan say NED as of 5/13
dx with severe cardiomyopathy 5/12 (likely due to chemo and Herceptin), ejection fraction in low 20's, now up to 40, went to 50, latest read 12/13 is back down to 35
1/13 Acute pancreatitis - are you kidding me?
9/13 started Humira for Crohn's. starting to have some energy again
B12 and Vit D both needed supplementation
Cataracts in both eyes noted 6/12 - surgery in the next 2-4 years?
4/14 Kidney stones/blockage/infection - related to Crohn's Disease
5/14 My aunt passed away - she was diagnosed after I was with Stage I - not Her2+, then Stage 4 for about one year
6/14 Scans - still NED, thank God. However, broken rib (I didn't notice) lots of bone degeneration osteopenia/osteoporosis. I also still have cardiomyopathy secondary to chemo.
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02-05-2008, 09:55 PM
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#5
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Hi Rebecca,
Yes, I was tested for TOPO 11.
When I was at the SABCS Dr. Slamon spoke again about the TOPO 11 test and the benefit of the test would be for those patients that have not had
treatment yet. If you are TOPO 11 positive than A/C chemo would be
the better treatment, if TOPO 11 negative then A/C chemo would not
chosen. Women who are TOPO 11 positive and Her2 would have a greater benefit from the A/C.
I was TOPO 11 negative and was tested by Dr. Slamon 2006 he advised
TCH which I did. He also advised that the TCH trials showed a small
difference between the A/C and TCH treatment I think it was a 3% difference and the TCH treatments did not increase heart risk to the patient.
I am glad this has been FINALLY approved by the FDA since in S.A.
one top Onc. was stating to Dr. Slamon on the panel one night that this test was not approved by our FDA (she was from France). Glad
that NOW woman will be able to test further what chemo will be their
best choice with less risk.
I was very surprised that many onc. do not even know about the test.
If you have any other questions just reach out.
Kind Regards,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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02-06-2008, 03:46 PM
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#6
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Senior Member
Join Date: Oct 2007
Posts: 203
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Thanks Jean
__________________
Dx 8/06 Age 43 Stage IIIA multifocal throughout breast, largest tumor 5 cm, grade 3, comedo, ER+PR+HER+++
Neoadjuvant A/C 4X Dose Dense
11/06 Bilateral Mastectomy (no choice on the right, my choice on the left)
Taxol+Herceptin weekly x12, continuing with Herceptin, finished one year in 12/07
33 Rads
Femara for 5+ years, staying on (started with Arimidex, switched after about a month, much happier)
Abnormal brain MRI shows no cancer, but "extensive white matter diease" - unknown cause
BRCA negative - lots of cancer in my family
survivor of thyroid cancer
also have Crohn's disease
CT and bone scan say NED as of 5/13
dx with severe cardiomyopathy 5/12 (likely due to chemo and Herceptin), ejection fraction in low 20's, now up to 40, went to 50, latest read 12/13 is back down to 35
1/13 Acute pancreatitis - are you kidding me?
9/13 started Humira for Crohn's. starting to have some energy again
B12 and Vit D both needed supplementation
Cataracts in both eyes noted 6/12 - surgery in the next 2-4 years?
4/14 Kidney stones/blockage/infection - related to Crohn's Disease
5/14 My aunt passed away - she was diagnosed after I was with Stage I - not Her2+, then Stage 4 for about one year
6/14 Scans - still NED, thank God. However, broken rib (I didn't notice) lots of bone degeneration osteopenia/osteoporosis. I also still have cardiomyopathy secondary to chemo.
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02-06-2008, 07:07 PM
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#7
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Senior Member
Join Date: Sep 2006
Location: Nebraska
Posts: 154
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I hope someone might now this..
I was tested for p13 after my tx was finished..that's when all the talk was about p13. Is this Topo II different from that? How do they differ? I had the test just for peace of mind.
__________________
Michele Ulmer
Dx.2003 Stage 3b 35 pos nodes
Dx August 2003 Stage 3B with 35/35 nodes IDC age 39
Lumpectomy
A/C x4 Taxol x12
35 radiation tx
1Year Herceptin in trial
HER2 vaccine trial Seattle
3 months Tykerb off label
NED
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02-06-2008, 10:20 PM
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#8
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Senior Member
Join Date: Oct 2005
Location: New Jersey
Posts: 3,154
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Hi Micheleu,
Love your new photo!
The TOPO2a is a different test. TOPO 2a is a gene we all carry,
if it is positive then the patient will have a significantly improved
response to A/C chemo. If you are negative the A/C will be of little
benefit. Most patients have not been tested for this as it was not available and was extreme cutting edge at the time.
The PTEN 13 marker applies to Herceptin. MD Anderson was doing the research on this. I had called and spoke with the research dr. who
was working on this and the research was halted do to funding.
She had hoped that another grant would be offered and their
work would resume. Most have not been tested for this like TOPO2a
especially since there was only herceptin at the time. Now we have
Tykerb.
Currently there is no testing to determine if herceptin will work.
The PTEN has not been confirmed yet and there is no data out
on this. I certainly hope the research at MD Anderson will
resume or at the very least be studied in another lab.
Best Regards,
Jean
__________________
Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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02-07-2008, 08:28 AM
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#9
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Senior Member
Join Date: Aug 2006
Location: Rowlett, TX
Posts: 138
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My onc recommended the test (September 2006). Am glad to see it's been approved. The test results determined which chemo drugs my onc recommended, so it was worth having it done.
__________________
Janet in Rowlett Texas
Dx July 2006 IDC 1.8cm, ER-/PR- HER2+ (FISH 7), KI67 High (60%) grade 3, TOPO II neg
Aug2006: lumpectomy, SNB (4 nodes neg), Stage 1
Jan 2007: Finished 6 cycles of TCH (Taxotere, Carboplatin, Her ceptin). Then Herceptin every 3 weeks.
Feb 2007: Completed Radiation
May 2007: Stopped Herceptin due to low LVEF (49%)
July 2007: LVEF now 44% -- starting Coreg
May 2008: Heart NORMAL! Yippee.
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02-07-2008, 10:24 AM
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#10
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Senior Member
Join Date: Sep 2006
Location: Nebraska
Posts: 154
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Thanks for the explaination!!
__________________
Michele Ulmer
Dx.2003 Stage 3b 35 pos nodes
Dx August 2003 Stage 3B with 35/35 nodes IDC age 39
Lumpectomy
A/C x4 Taxol x12
35 radiation tx
1Year Herceptin in trial
HER2 vaccine trial Seattle
3 months Tykerb off label
NED
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