Xeloda/Tykerb side effects

02-09-2009, 09:31 AM

Shortly, I am going to start this combination and am worried about the side effects. Can anyone share how quickly they start (nausea, diarrhea, rashes, H+FS? Within a week? Within two weeks? Anyone out there who has tolerated the combination well with few or no side effects? Once they start, do they get better once your body gets used to it? Has anyone used henna to relieve the HFS? Any hints or insight anyone can provide would be most welcome!!

Carolyns · 02-09-2009, 09:44 AM

Hi,

I just started on Friday and am taking 5 Tykerb in the morning and 2 Xeloda pills in the morning and in the evening. Sunday evening I had some diarrhea and I feel more tired than usual.

Good luck, Carolyn

Bill · 02-09-2009, 08:11 PM

Hi Sammie! My wife, Nicola, was on Tykerb and Xeloda at different times. I seem to recall that she had diarrhea pretty quick with the Tykerb, but it was an effective treatment. I'd recommend starting a "BRAT" diet pretty quick, possibly avoiding severe diarrhea. As for Xeloda, she never really got Hand and Foot Syndrome, just diarrhea again. Many women here have been on this treatment, but the one I always think of is Hutchibk, Brenda. I'm sure she can help alot more than I can. Thoughts and prayers to you. Love, Bill

jones7676 · 02-10-2009, 03:37 AM

I had some trouble with diarrhea problems at first but I greatly increased the portion of my diet that included the "BRAT" diet and found that I only occasionally needed other medications to control it. That would usually happen when something I ate caused it and I kept a list of irritants on my frig and avoided them. Good luck.

Pam P · 02-10-2009, 05:57 AM

I was on xeloda/herceptin for over 2 yrs, then switched to xeloda/tykerb for another 1 1/2. It was the best I've felt on any chemo. I did have side effects, but they were manageable. Diarrhea at first - sometimes severe, but imodium kept it in control. After awhile I guess I my body adapted because it was no longer an issue. My blood counts always stayed in normal ranges. I did feel a little more tired sometimes - I could tell the difference when it was my week off the xeloda that I had more energy. My biggest difficulty was the hand/food syndrome. I got severe at times. I tried lots of lotions. Unfortunately I didn't know about the henna treatment. On the week off xeloda it would clear up a lot. I had my xeloda dose reduced and that helped. I think I started out at 4000 mg & went to 3500, then 3000. I think others have been on 2500 and done fine on the xeloda. I wish I could still be on that combo. I also liked not having to get treatment by IV - it felt freeing to just take the pills.