"significantly imroved" 2 yr disease ree survival if 1 yr of neratinib given after

[Debbie L.]

Thanks for posting this, Lani.

So, what do we think of the information? I've heard that neratinib is a tough one, mostly d/t the diarrhea. Do you think that trying to manage the side effects for a whole year is worth the "significant" difference (2.3%, by my math) in disease-free survival? Maybe for high risk stage III but not for stage I (because the higher the risk, the higher the absolute benefit)?

Debbie Laxague