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12-11-2006, 06:57 PM
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#1
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Senior Member
Join Date: Oct 2006
Location: Connecticut, USA
Posts: 29
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Getting started with Doxil
Today Sarah got her first round of doxil. After telling us about the reduced level of side effects the nurse then proceeded to detail several pages of "do's and don'ts" for preventing additional side effects. Browsing around I find that some people find Doxil a walk in the park and others seem to get hammered. I hope it goes smoothly for Sarah, she has been kicked around lately. Anyone have experience with Doxil, or advice on management of side effects? Looks like mouth sores and hand-foot syndrome are the biggest problems.
thanks.
Steve
__________________
Sarah's history:
DX Sept 03 Stage 2B Grade 3
BRCA 1 positive
RT Mastectomy
4 cm lobular 1+node ER-/PR- Her2+
chemo 2004:
4 cycles AC
4 cycles Taxol
herceptin 2004-2005
june 06 stage IV: lung, bones
weekly taxol
1/3wk herceptin
Oct/November 06: new primary left breast
ductal 4cm+
mastectomy
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12-11-2006, 09:50 PM
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#2
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Senior Member
Join Date: Dec 2005
Location: Alexandria, VA
Posts: 1,055
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Looks like a close relative to the A in AC. I did doxirubicin myself. Lost my appetite and felt weird for a few days. . I did lots of pre-emptive sleeping. Good luck and check out this site for more info .
http://www.breastcancer.org/research...apy_doxil.html |
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12-11-2006, 11:45 PM
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#3
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Steve,
A good site to check out chemo drugs is:
http://www.chemocare.com/bio/
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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12-12-2006, 11:26 AM
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#4
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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Thank you for listing that sight. Pretty much sums up all you need to know about chemo drugs.
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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12-12-2006, 09:44 PM
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#5
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Senior Member
Join Date: Dec 2005
Location: Alexandria, VA
Posts: 1,055
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I forgot. Onc nurse said to do B6 daily for neuropathy. Worked for me. BB
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12-13-2006, 08:20 AM
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#6
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Senior Member
Join Date: Sep 2005
Location: Philadelphia
Posts: 301
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I've had 3 treatments of doxil (getting it every 2 weeks since I get Avastin also). This has been a tough one for me. Aside from the busy time of year, I've still been trying to work full time and care for our 2 young girls and do the usual other stuff. Despite religiously using the cold compresses during infusion, I did get the H/F again (had it w/ xeloda). My mucous membrane are also very inflamed.
I asked not to get my 4th treatment until I got a cat scan - it's too hard for me to take unless I know it's working - I should get the results later this week....
Good luck with it,
Shell
__________________
Shell
init diag 3/17/03-stage IIIC
ER-/PR-/HER2+++
CET x4 neo-adjuvant
lump & SNB 8/03
CET x2
radiation and herceptin/navelbine 11-03-1/04
1st reoccur to lymph nodes 8/04
complete axillary dissection 12/04
herceptin/taxotere til progression (lungs) 3/05
xeloda w/out lapatinib trial 6/05
lapatinib/tykerb added 4/06
ended trial 8/06 due to progression
doxil / avastin 11/06-12/06 - wasn't working
navelbine/herceptin/avastin 12/06/3/07 - progression
gemzar/carboplatin/tykerb 4/07
mri shows extensive mets to bone in pelvic area 6/07
switched to abraxane (3 on/1 off) + tykerb 6/07
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12-13-2006, 05:32 PM
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#7
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Senior Member
Join Date: Oct 2006
Location: Connecticut, USA
Posts: 29
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Well I for one can't imagine trying to work full time OR care for two girls while on chemo, let alone both. More power to you, Shell.
To everyone - thanks for the posts, it is all very helpful.
Now if we can get Sarah's kidneys working right we can move ahead. She was readmitted today with high creat, looks like last week's fix didn't take.
Steve
__________________
Sarah's history:
DX Sept 03 Stage 2B Grade 3
BRCA 1 positive
RT Mastectomy
4 cm lobular 1+node ER-/PR- Her2+
chemo 2004:
4 cycles AC
4 cycles Taxol
herceptin 2004-2005
june 06 stage IV: lung, bones
weekly taxol
1/3wk herceptin
Oct/November 06: new primary left breast
ductal 4cm+
mastectomy
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12-14-2006, 08:56 AM
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#8
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Sorry to hear that Sarah is in the hospital again. Here's hoping that they will get the right fix this time.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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