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Old 11-05-2009, 10:00 AM   #21
julierene
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Re: Waiting on Trial, got Brain Mets...

Thanks, I am so glad you mentioned my ex. I have felt such a renewed sense of anger at him lately, that I can barely go a few minutes without some sort of horrid wish upon him. He only confessed his sins to me at the end of June, after 9 years ago that he committed the adultery. I guess I shouldn't be so hard on myself for still hating him for what he did. And especially why he won't tell me why he did it. I feel I deserve to know that much...
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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Old 11-05-2009, 05:14 PM   #22
chrisy
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Re: Waiting on Trial, got Brain Mets...

Remember Julie, your anger only hurts you...it doesn't touch him. Take care of your sweet self!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 11-06-2009, 12:27 AM   #23
StephN
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Re: Waiting on Trial, got Brain Mets...

Yes Julierene, I was going to mention that you will probably never know the WHY, and it is a waste of your precious life energy to spend it on a man who is not worth it. You need to use your focused energy to get well and heal.

The WBR will take it out of you, so spare yourself any emotional upset and make the best of the days ahead.
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"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.

MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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Old 11-06-2009, 05:40 AM   #24
whatz
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Re: Waiting on Trial, got Brain Mets...

I agree with Steph. Don't beat yourself up for not already have forgiven, pray for the ability to be able to forgive and move on. Cheating in a relationship is probably the hardest thing I can think of to forgive, but if you can it will release you more that it will him since, as Chrisy has already pointed out, the anger's pain and hurt is only directed at yourself (does not phase him in the least). You are worth more than that, girl! You are worth more than needing an ex-husbands acknowledgment! Sounds like from your earlier post that your boyfriend has recognized that you are soo worth it.
__________________
4/09 suspicious lump in left breast
5/09 biopsi lead to diagnosis ER/PR -
Her2+.Grade 3,full masectomy left breast,sentinel nodes clear,Stage 1
6/09 Adriamycin + Cytoxan 4 treatments (every 3 weeks) followed by Taxol + Herceptin, 1 treatment weekly for 12 weeks, followed by Herceptin for 40 weeks
MRI Brain 4/10 clear
CT Body 4/10 clear
PET Body 2/11 clear
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Old 11-06-2009, 07:22 AM   #25
julierene
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Re: Waiting on Trial, got Brain Mets...

I sure hope so! At times, I just feel like I was supposed to be the smart one and chosen my mate well. He fooled me in every sense of the imagination, and took away my ability to think of him in any other way than - VILE. Every time I have to almost be around him, I physically get almost vomit sick. Once, I actually pulled over and thought I would hurl everywhere.

Then I think about all the things he did to make me do everything, and how he was always so lazy and worthless. I feel so overwhelmed with upset with myself for being deceived for so many years. It didn't do me any good to not see through him. Ignorance is not bliss.

I know my rants right now, and aside from my health issues. But coming to terms with some of these things seems just so tied-in at times. I just wish that at some point, he will see that what he did to me was unforgivable and that he will never be happy with himself again. But I see that he is the one who finds happiness, and I am the one who has been left with all the garbage. He dumped his crap on me, and I feel so covered in filth.
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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Old 11-06-2009, 09:25 AM   #26
chrisy
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Re: Waiting on Trial, got Brain Mets...

Julie,
Maybe you should hurl all over him!

I once threw up all over my date (it was early in the relationship). It was only after many years I learned that he was one of those special people who needed to have vomit on his new shirt.
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 11-06-2009, 10:54 AM   #27
julierene
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Re: Waiting on Trial, got Brain Mets...

HEHEHE! Good laugh!!!
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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Old 11-06-2009, 12:20 PM   #28
Becky
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Re: Waiting on Trial, got Brain Mets...

Dear Julierene

This kind of betrayal is very,very difficult to handle but it is his weakness and not yours. He is also your ex problem and someone else's current problem.

I always go by the Serenity Prayer used by AA, NA, Al-Anon etc:

God grant me the serenity
to accept the things I cannot change;
courage to change the things I can;
and wisdom to know the difference.


The past is the past and you cannot change it. You can only change today and plan on tomorrow.

Hugs
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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Old 11-06-2009, 01:10 PM   #29
julierene
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Re: Waiting on Trial, got Brain Mets...

I kinda wish I had an way to just burn it all from my mind. His Mormon beliefs disgust me to this day, (sorry to any Mormons I may have offended) and I feel like I will forever be the victim of my own lack of judgment. I find it hard to forgive myself for the man that I chose.
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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Old 11-06-2009, 02:12 PM   #30
MJo
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Re: Waiting on Trial, got Brain Mets...

Time will help you forget. And you need to destroy those mets so you have lots of time. I made a horrendous choice too and lost 6 important years of my life in my 20s. I comfort myself that I never have to be that stupid again. It's really a comfort. Just think..you never again have to be that stupid about a man. You never have to live that way again. As the song goes "I'm so glad I'm not young anymore."
__________________
MJO

IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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Old 11-08-2009, 10:15 PM   #31
Catherine
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Re: Waiting on Trial, got Brain Mets...

Hi Julie,

Your girlfriend troops are on the offensive. Medically, you seem to understand what is available and you have the back up and knowledge from the troops here. Emotionally, with the EX....Poop on him and the new squeeze. Never let him make you feel bad about yourself, you learned a lesson from him. You do not need to put up with a liar and a cheat and you do not need to forgive him for hurting you. Your children will always love you and realize that you are their real mom. Unfortunately, their real dad will probably lie to them some day. But we know that children always figure it out. You are a dear and I am so glad that you have wonderful parents, nice little kids and a wonderful boyfriend. Pamper yourself whenever you get a chance. Sorry to hear about the hair, you deserve to be tried of having it fall out. Hugs and love from all of us.

Catherine
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Catherine


Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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Old 11-09-2009, 07:29 AM   #32
WomanofSteel
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Re: Waiting on Trial, got Brain Mets...

I think Becky had some wise advice. I would also like to add that someone like that is not worth wasting your precious moments with those who love you now. Let it go for your own health. Good luck to you with your new treatment. Will say a prayer for you.
__________________
dx aug 03
invasive dcis 1 cm
er/pr/her2+
bcs 8/4/03
bcs 8/21/03 0/16 nodes
tx 4x ca 36 rad tam
postmenopausal 06 aromasin
sept 07 biopsy node in neck
muga/pet/cat/bone mets to lungs nodes and liver stage iv
tx hki-272
tx not working switched to taxol herceptin
Taxol not working switched to navelbine
navelbine is causing bad neuropathy
starting gemzar
gemzar quit on me now on Ixempra due to increasing number and size of liver mets
another progression starting tykerb/xeloda
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Old 11-09-2009, 08:35 AM   #33
julierene
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Re: Waiting on Trial, got Brain Mets...

I want nothing more... I despise everything about him, and I am even more devastated that he will raise my children after I am gone. I hate that more than anything I could ever say I hate more than hate. I have always prided myself on not hating, and now I am being constantly covered in it no matter how I try to get away. My mind is my worst enemy, and I can't get my filthy evil ex-husband out of my beautiful mind. I feel like he successfully destroyed me and all the good thoughts I had left of the world. I have always been such a positive person, in the face of such tragedy with my family cancer history. In one night, and two seconds of him spewing his sperm between another woman's legs, he might as well have took a knife and ripped out my heart. All for a two second spew of sperm. I have never heard of anything more stupid in my whole entire life to destroy a faith in someone. I try to tell myself it could have been worse, but for some reason, I can't seem to believe it. I think about how he ruined my marriage, tore up our family, and then goes about his life like he's happy now. Purposefully trying to make my life miserable any time he can. I think his abuse goes far above something he should be put in jail for. And when I think about him rotting in jail, it just makes me smile. Some day, a day I will probably never see, I just want him to learn what a miserable person he is, how he doesn't deserve a new wife, and doesn't deserve my precious children that he cheated on.
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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Old 11-09-2009, 10:26 AM   #34
MJo
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Re: Waiting on Trial, got Brain Mets...

RE: I have always prided myself on not hating

Those of us who would rather shoot first and forgive later welcome you. Does that make you a bad person? Only if you actually shoot him. That would make you a bad person. Please don't do that.

P.S. I just read your post to Joy. You do good work.
__________________
MJO

IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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Old 11-09-2009, 10:33 AM   #35
julierene
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Posts: 327
Re: Waiting on Trial, got Brain Mets...

He already shot and emotionally killed me first with his adultery. I will never see revenge and that seems to really hurt me the most. He will likely live on way past me, taint my children to the Mormon religion, and ruin everything I have worked so hard for to instill goodness in them.
__________________
Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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Old 11-09-2009, 03:58 PM   #36
Sheila
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Re: Waiting on Trial, got Brain Mets...

Julierene
Say your energy for fighting this disease and staying alive for your children...you will never change him, and you are wasting time and energy even thinking about him....the best payback you can give him is to stay alive to raise your children....so focus on positive things for yourself, his ways will take care of him...if he cheated on you, he will cheat on her.....be the better person and live for your children! They will know the truth one day!
__________________
"Be kinder than necessary, for everyone you meet
is fighting some kind of battle."



Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 11-10-2009, 11:37 AM   #37
MJo
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Re: Waiting on Trial, got Brain Mets...

I agree with Sheila. I wish you didn't have the mets, but given that you do, your job is to destroy the cancer and stay alive for yourself and your children. Plus, it sounds like you are going to be a pioneer for the rest of us in this clinical trial you are fighting to join. I think you also give sensible and reassuring advice to others. I honor you.
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
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Old 11-10-2009, 06:33 PM   #38
Jaimieh
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Re: Waiting on Trial, got Brain Mets...

Julierene~ I hope the WBR takes care of the brain mets. In the mean time the best thing that you can do to piss him off is keep fighting and keep raising your kids. I had an Ex that cheated on me we were engaged and it ate me up. I spent a ton of time stressing over it to only learn that he is not/was not worth it. In the end it will come back to him.
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Diag. 12/24/08-
IDC 1.3 er-/pr- HER2+
Grade 3 0/2 lymph nodes
no angiolympathic invasion

Bi-Lat. Mast. 1/8/09
Exchange scheduled for 6/17/09
Lost implants due to unknown reason :(

Hip Flap 1/26/2010 in NOLA :) LOVE EM'

TCH x6 (6 done and I am hoping to never do it again )

Well so much for never...
Local recurrence May 25,2014 is left over breast tissue.
April 2 , 2014 lumpectomy
April 28, 2014- June 9, 2014 start AC x 4
Taxol x12
Perjeta x 6
Herceptin x 18
And 33 rads just for fun. NOT!!!
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Old 11-12-2009, 07:48 PM   #39
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Re: Waiting on Trial, got Brain Mets...

I remember you said you had a p53 "issue" maybe the following will give you some hope

This is Lani, but since the website update I am just unregistered and unable to sign in...

Cornell researchers identify a weak link in cancer cell armor

ITHACA, N.Y. – The seeming invincibility of cancerous tumors may be crumbling, thanks to a promising new gene therapy that eliminates the ability of certain cells to repair themselves. Researchers at the Cornell University College of Veterinary Medicine have discovered that inactivation of a DNA repair gene called Hus1 efficiently kills cells lacking p53 -- a gene mutated in the majority of human cancers.

Using a mouse model, senior author Robert Weiss, associate professor of molecular genetics, first author and graduate student Stephanie Yazinski and colleagues explored how cells respond when both genes are inhibited. When they inactivated the Hus1 gene in healthy mammary gland tissues, the researchers report, it caused genome damage and cell death. And when they studied the effects of Hus1 inactivation in p53-deficient cells, which are highly resistant to cell death, they discovered that the ability of Hus1 inactivation to kill cells was even greater.

The study is published in the Proceedings of the National Academy of Sciences (Nov. 9).

"Our work contributes to an important new understanding of cancer cells and their weaknesses," Weiss said. "The mutations that allow cancer cells to divide uncontrollably also make the cancer cells more dependent on certain cellular processes. We were able to exploit one such dependency of p53-deficient cells and could efficiently kill these cells by inhibiting Hus1."

Weiss and his team have new experiments under way. "We've proven the power of inhibiting both pathways in normal tissue," said Weiss. "Now we want to extend our knowledge to cancerous tissue and determine if the loss of Hus1 will impact the ability of cancers with p53 mutations to take hold and grow."

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Weiss's research was funded by the National Institutes of Health and is now funded through 2013 in part by the American Recovery and Reinvestment Act (ARRA). To date, Cornell has received 124 ARRA grants, totaling more than $99.9 million. Weiss's ARRA funding will support one faculty and two student positions as well as the research activities of several additional lab members.
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Old 11-12-2009, 08:42 PM   #40
Laurel
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Re: Waiting on Trial, got Brain Mets...

Julie,

This is not the easiest post for me to write. You are not the only one who has lived through an abusive relationship. I know what it is like to be literally drowning in my own blood, because I had my nose broken so badly my throat was so full of blood I could not breathe. I know what it is like to have the ex not hold a job when you are working a full time and a part-time job, exhausted and still drowning beneath the bills. I know what is like to have them cheat on you with some young filly.

You did the right thing in leaving. Now only you can heal yourself so you can go on living. The truth is you will not feel better until you forgive him. Forgiveness is a choice and you simply choose to forgive, decompress, and move on. You let go. Do you know what you find when you let all that anger and disgust die? You heal and have peace. Sometimes I think bitterness eats at us like a cancer.

Give it a try. It might surprise you at how empowered you feel letting it go and stepping back. I find with difficult people you must "change the steps of the dance." It totally blows them away! Instead of reacting to things in the same old manner, you decide how you are going to change YOUR response to your ex. When you play differently, it places you in control and they are forced to dance a different step too. It is very empowering and privately you will marvel at how easy it is to "manage" the unmanageable!

Good luck with this new trial. It looks so wonderfully exciting for you! Praying 2010 is a fabulous year for you, Julie!
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Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara

15 Years NED
I think I just might hang around awhile....

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