Pl help:Failed perjetA, now TDM1?

[Sdgirl]

Rolepaul,
My neuro oncologist refuses to give me IT Herceptin. I have taken all the studies on this and emailed information that you have posted on this topic. He said he had given me prophalactic tx and it was enough for now. I am also battling progression in the liver and lungs and this has taken a back seat. The TDM1 trial does not allow any other tx. So I am stuck either way. Thank you for the information you post on this. I am going to continue to make the case with my doctor so we are ready.

[Jackie07]

Most of our members have reponded well to T-DM1 with little side effects. There're quite a few threads which you can locate by using the 'Search' button on the top bar. Below are two of them:

http://her2support.org/vbulletin/sho...ighlight=T-DM1

http://her2support.org/vbulletin/sho...hlight=T-DM%21

[Pray]

I'm hoping and praying very hard it works. Gods blessings to you and your wonderful little family. Peace my friend.

[phil]

So glad you get to try this awesome drug . It is the strongest drug for her2, stronger than perjeta, which is an antibody, not a chemo, like original herc. t dm-1 is the first ever conjugate , antibody armed w/ chemo. there are others in early stage trials . has the " best survival stats EVER so far " for her2 bc. heres praying for great results !

[fullofbeans]

I had progressed on herc and tykerb and tdm1 kept me stable for a while. I also think it is one of the best option if you can have it. no one can know what will work for you but data shows that around 55% will not respond to tdm1 but this rate is lower that for the other drugs, so it is a good educated guess. my best wishes

[phil]

FOB , what about herc/nav, or herc gemzar , if you havent tried them. i know someone who progr on t dm-1 , switched to herc /nav about 4 months ago. doing very well, especially since they lowered nav dose to reduce s/e. some folks seem to have pos after -effects from t dm-1's blast , even if not total . deena h's combo is intersting too.

[deb808]

Hi SDgirl,
Hope that the TDM1 will work for you and beat back those mets. I also have tried several treatments and they all eventually stopped working. It's hard not to lose faith and the thought of starting yet another round of trtmnt is upsetting but you just have to keep trying. I may possibly get on TDM1 too at some point. It seems that is how to fight this disease, keep trying other treatment options until you find what works. We can only hope that somehow it will be figured out how to treat and manage this disease better. Stay strong and take care of yourself. My children are my incentive and inspiration to fight harder. Will keep you in prayers that this treatment will work.