Aromatase Inhibitors: Personalized dosing?

[Hopeful]

Trying to recall the name of an older thread on this board that dealt with a similar question, only it had to do with how quickly the body metabolizes a drug. As I recall it, for all drugs, there are fast metabolizers and slow metabolizers. There is a certain level of the drug that is supposed to be sustained in the body during treatment. The standard dosing for the drug is based on the clearance rate of the fastest metabolizers, in order to make sure that everyone who uses the drug gets the benefit they are supposed to from it. Unfortunately, the slower metabolizers wind up with a higher level of the drug in their body because they can't clear it as quickly. This may result in more prominent side effects from it. So, it is not just a body mass question but a metabolizing speed question to determine the optimum individual dosing.

Hopeful