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04-20-2008, 08:30 PM
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#1
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Guest
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Anyone having TCH chemo for er-pr-her2, node invovemnet
Really afraid of antracyclines, heart desease runs in family. Was thinking of doing just TCH and followed by radiation. Anyone else here choose this path?
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04-20-2008, 08:33 PM
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#2
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Member
Join Date: Mar 2008
Posts: 24
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er-pr- her2, node involvement-anyone having TCH chemo
Sorry forgot to register for previous thread
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04-21-2008, 04:56 AM
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#3
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Senior Member
Join Date: Jun 2006
Location: San Antonio, TX
Posts: 2,357
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Hey, my dad had serious heart problems, but I did do Adriamycin and Taxotere x 3 and then Taxol, Carboplatin & Herceptin, then Navelbine & Herceptin with no heart problems. Guess I got my mom's heart! Also did 33 radiations. Good luck on your treatment plan decisions. It's not an easy decision, but there's lots of info to read. ma
__________________
MA in TX.
Grateful for each and every day....
Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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04-21-2008, 09:19 AM
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#4
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Senior Member
Join Date: Sep 2005
Posts: 38
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Although I had no node involvement, I recieved TCH, followed by radiation. That was in early 2004, and I'm currently NED. I was HER2+, er/pr-, Stage 2A. When the studies came out about TCH being, shall I say, easier on the heart, my Onc. said she was on the phone telling as many Oncs. as she could to use THC. I had no heart problems and after, I think, 6 months my MUGA score was higher than at the beginning of treatment.
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04-21-2008, 09:24 AM
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#5
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Senior Member
Join Date: Apr 2006
Location: Wilmington, Del.
Posts: 1,126
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Things change so quickly. In 2006 when I started chemo, I didn't know of anyone getting the TCH combo. Haven't there been studies that TCH is just as effective as AC/Taxol/Herceptin. If you can get the same results from TCH, I say avoid anthracyclines. Unless there are new studies out that recommend AC again. As I said, things seem to change from year to year.
__________________
MJO
IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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04-21-2008, 05:24 PM
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#6
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Senior Member
Join Date: Apr 2008
Location: Sunny San Diego
Posts: 2,214
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Starting TH in May
I'm starting TH in May. I didn't want Adriamycin or Cytoxan due to the cardiotoxicities and the risk of future leukemias.
I talked my oncologist into the TOP2A test which showed Adriamycin was most likely not effective for me.
I'm waiting for the results of the BRCA1 & BRCA2 to decide about the C in TCH, platinum salts.
I wish you the best with your treatment.
__________________
Diagnosed 2007
Stage IIb Invasive Ductal Carcinoma, Pagets, 3 of 15 positive nodes
Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"
Additional treatments:
GP2 vaccine, San Antonio Med Ctr
Prescriptive Exercise for Cancer Patients
ENERGY Study, UCSD La Jolla
Reconstruction: TRAM flap, partial loss, Revision
The content of my posts are meant for informational purposes only. The medical information is intended for general information only and should not be used in any way to diagnose, treat, cure, or prevent disease
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04-21-2008, 08:14 PM
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#7
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Member
Join Date: Mar 2008
Posts: 24
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Platinum salts?
Hi lizbeth I am not aware of what brac1 an 2 have to do with the carboplatin in TCH. I was tested for brac1 and 2, but do not know the results yet. What is the correlation between these two things? Thanks
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04-21-2008, 09:01 PM
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#8
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Senior Member
Join Date: Apr 2008
Location: Sunny San Diego
Posts: 2,214
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Platinum Salts Brca1&2
Hello Tomatojuice,
I had seen a posting from Jean that showed similar results on a study comparing TCH & TH. So I felt pretty good going with just TH.
However, I'm waiting on the results from my BRCA tests too.
I saw something on Wikipedia that mentioned that the Platinum Salts were 20 times more effective with the BRCA gene mutations. I thought I'd research that more while I'm waiting for my results.
Maybe someone else in the group is more familiar. If I find something informative I'll let you know.
'lizbeth
__________________
Diagnosed 2007
Stage IIb Invasive Ductal Carcinoma, Pagets, 3 of 15 positive nodes
Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"
Additional treatments:
GP2 vaccine, San Antonio Med Ctr
Prescriptive Exercise for Cancer Patients
ENERGY Study, UCSD La Jolla
Reconstruction: TRAM flap, partial loss, Revision
The content of my posts are meant for informational purposes only. The medical information is intended for general information only and should not be used in any way to diagnose, treat, cure, or prevent disease
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04-22-2008, 07:47 PM
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#9
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Senior Member
Join Date: Jan 2008
Location: Evergreen, Colorado
Posts: 454
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TJ,
I just wrapped up the Taxotere for 6 cycles. (3 weeks) + Herceptin (given at the same time as the Taxotere). This must be quite the powerful combo because a pet/ct scan after the 3rd cycle showed that it had kicked the met in my liver.
But we forged ahead for the remaining 3 cycles.
I had to ask for Radiation, my onc "slipped" and was about to say they "typically" they don't perform rads on metastatic patients. Due to the information provided by members of this site, I had the courage to look my onc squarely in the face and ask "why not???" So...I am finishing up my 6th week of radiation. (I hope it pays off)
So....for now...celebrating NED (I need to update my signature)
Bottom line (sorry...what a long winded response) TH worked for me!!!
__________________
2007
Oct - Diagnosed - Stage IV 5 c.m. IDC - Left Side er/pr- Her2+++ Node + 2/14 - Single Liver Met Double Mastectomy Nov - Begin T+H 2008
Feb-Complete 6 cycles- T&H- NED
March - Continue - Herceptin Only
April - Rads for 6 weeks
2009
Continue Herceptin - Continue NED
April - Recurrance- 3 cm. Liver Met
May - Cryosurgery
June - November - Abraxane + Herceptin
Aug - PET/CT - CTC = 0 Back to NED
2010
January - Continue NED
July - Recurrance - 3 cm Liver Met CTC=1
August - Cryosurgery #2
August - November Navelbine
November - Back to NED - End Navelbine
2011
Feb - Recur - 4 cm Liver Met - Same Left Lobe
March Surgery it is -Couldn't get a clean margin
July - Confirmed continued liver involvement
August - Begin Herceptin + Tykerb
October - Mixed results from H+T
Add Abraxane + H + T - Nov - April
2012
January PET Scan - It's working!!
April - Back to NED
July - Recurrance
August - Begin TDM-1 Trial (Taxol + TDM-1)
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04-23-2008, 06:36 AM
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#10
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Senior Member
Join Date: Sep 2005
Posts: 202
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I was on the TCH arm in the BRCIG study. 4 years NED! Worked for me and no heart problems. My best to you.
__________________
Take care, k
DX: 10/29/03-Stage IIB, 3/12 nodes +, er/pr-,
Grade 3
MRM: 11/07/03
TX: TCH-BRICG Study-6 tx's; 12/15/03
Herceptin; til 12/14/04
Rads: 30 days
BRCA neg
S-Gap: 12/15/04
Oct 05: LAVH
NED
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04-23-2008, 10:49 AM
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#11
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Senior Member
Join Date: Apr 2008
Location: Sunny San Diego
Posts: 2,214
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Carboplatin and BRCA1&2
http://www.timesonline.co.uk/tol/new...icle711744.ece
This is the mention of BRCA and platinum salts I saw on Wikipedia.
I have searched on the internet and haven't found much.
'lizbeth
__________________
Diagnosed 2007
Stage IIb Invasive Ductal Carcinoma, Pagets, 3 of 15 positive nodes
Traditional Treatment: Mastectomy and Axillary Node Dissection followed by Taxotere, 6 treatments and 1 year of Herceptin, no radiation
Former Chemo Ninja "Takizi Zukuchiri"
Additional treatments:
GP2 vaccine, San Antonio Med Ctr
Prescriptive Exercise for Cancer Patients
ENERGY Study, UCSD La Jolla
Reconstruction: TRAM flap, partial loss, Revision
The content of my posts are meant for informational purposes only. The medical information is intended for general information only and should not be used in any way to diagnose, treat, cure, or prevent disease
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04-23-2008, 02:41 PM
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#12
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Senior Member
Join Date: Jan 2008
Location: Carmel, Indiana
Posts: 98
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Hi,
I did TCH this fall. My oncologist told me that was the best combo for my type of cancer.
Good luck in your treatment.
Beth
Beth
__________________
DX 9-19-07 at age 40
DCIS, Inv. Duct. Car. 3 cm
Positive lymph node biopsy
Er+Pr+Her+++
Carboplatin/Taxotere/Herceptin
10-1-07 -- 1-16-08
Herceptin every 3 weeks until 9/24/08
Lump. and node dissection 2-12-08
BRCA1 and 2 negative
30 rads finished 4-23-08
oophorectomy 5-6-08
Femara started 5/25/08
Zometa for osteoporosis every 6 mo. started 9-24-08
Married 16 years!
3 kids - daughter (10), twin sons (7)
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04-24-2008, 06:17 PM
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#13
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Member
Join Date: Mar 2008
Posts: 24
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Thank You Kristen
You made my night. Just got home after 1st neulasta shot after first TCH yesterday. Everythings great so far. Just so wonderful to hear from someone with such a similar diagnosis to mine. What an inspiration. Keep being strong and healthy. Many hugs to you.
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04-24-2008, 06:21 PM
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#14
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Member
Join Date: Mar 2008
Posts: 24
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Thanks so much Lori
Another great inspiration. I have read of other women with liver mets that dissapeared. Think its the herceptin. God its just great. Keep being strong and healthy. Many hugs to you.
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04-24-2008, 06:23 PM
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#15
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Member
Join Date: Mar 2008
Posts: 24
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Thanks Beth
Loved hearing from you. I know its a good combo. Love getting the affirmation. Health and strength to you, and many hugs.
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