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Old 04-02-2010, 06:19 PM   #1
shondagaylord
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Question Chemo AND Tykerb & Herceptain??

Has anyone also added a chemo drug with Tykerb and Herceptain? If so which one?

Shonda
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36 M 5 children 16,12,9,7 yr old twins
DX 2-06 at 33 yrs old
4-06 Bi lateral mastectomyw/ recon
5-06 Taxol/Carbo Herceptain weekly
Have Mets in bone dx'd 1 week after surgery
5-07 Implant exchange
Chemo Holiday about 1 year
started Tykerb/Xeloda 6 days (Very sick)
Started Gemzar did 2 rounds (got very sick) In hospital 3 months w/ ARDS and TTP and CMV.
1-09 Started Navelbine/Herceptain weekly
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Old 04-02-2010, 07:22 PM   #2
Jackie07
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Re: Chemo AND Tykerb & Herceptain??

Shonda,

Here's a trial with just Tykerb and Herceptin:

http://www.caring4cancer.com/go/canc...wsItemId=42109

Seems Tykerb used to be always administered with xeloda. I think you can locate several postings on this Board.

Here's a link to the Tykerb site: http://www.tykerb.com/
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Old 05-23-2010, 07:02 AM   #3
Pushpa
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Re: Chemo AND Tykerb & Herceptain??

My mom is in Navelbine/tykerb for a week now. it was hard choice to make between tykerb and herceptin. tykerb has moderate to severe side effects with diarrhea, whereas herceptin is seamless. however tykerb blocks her1 and her2 receptors and can also move into the brain and work against brain mets.
unfortunately my onc did not want to give herceptin+tykerb to my mom here in india saying its still not proven strategy.
you have to do some reading before you convince yourself.
all the best
Raj
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Old 05-24-2010, 05:10 AM   #4
pibikay
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Re: Chemo AND Tykerb & Herceptain??

My wife is on Taxoterne and Zolefest along with Herceptin,
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Old 05-24-2010, 11:29 AM   #5
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Re: Chemo AND Tykerb & Herceptain??

I had Taxol with tykerb and herceptin first, then FEC with tykerb and herceptin also. Had great results.(neoadjuvant chemo)

best of luck!
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Old 05-24-2010, 06:54 PM   #6
Sandra in GA
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Re: Chemo AND Tykerb & Herceptain??

I was in a phase II study that added Tykerb to Herceptin along with the traditional chemos; adramycin, cytoxin, and taxol. I had four cycles of A/C and then began Herceptin andTaxol weekly for 12 weeks. At the same time I began taking Tykerb orally. After the 12 weeks, I continued with Herceptin and Tykerb for a total of one year.
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Diagnosed: 7/25/08 ~ age 63, no family history
Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
Vaccine: Walter Reed GP2/AE37 vaccine study ~ last booster 9/17/2012
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Old 05-24-2010, 08:38 PM   #7
hutchibk
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Re: Chemo AND Tykerb & Herceptain??

Wow, Sandra, Herceptin with Adria? Tough on the heart...
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Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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Old 05-26-2010, 01:18 PM   #8
Sandra in GA
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Re: Chemo AND Tykerb & Herceptain??

Brenda,
Thanks for your concern!

I guess I am just a tough old knot! I was in a phase II study at Mayo in Jacksonville FL that Dr. Edith Perez headed along with a Dr from Denmark. The Allto trials are the phase III for lapatinib for this study. They kept very close check on my heart function by doing echos every three months and that old ticker did great. I don't have the fulll name of the study, but it did have the phrase "cardiac safety and tolerability" in it. One arm of the Allto trials is exactly like the treatment I received. The other arms are looking at the patients receiving lapatinib or Herceptin alone. Another is looking at following Herceptin with lapatinib. Believe it or not, I actually am glad I got "all the big guns." It is amazing what having 21 positive lymph nodes will inspire you to do!

Sandra
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Diagnosed: 7/25/08 ~ age 63, no family history
Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
Vaccine: Walter Reed GP2/AE37 vaccine study ~ last booster 9/17/2012
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Old 05-30-2010, 02:55 PM   #9
Darlene Denise
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Re: Chemo AND Tykerb & Herceptain??

I did Xeloda, Tykerb & Herceptin. Had unmanageable side effects and progression.
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12/14/07 IDC ER- PR- HER2+++ LIVER METS AT DX CONFIRMED BY LIVER BIOPSY
01/14/08 2 AC TREATMENTS-NOT WORKING
02/04/08 13 TAXOL, CARBO, HERCEPTIN TREATMENT-EXCELLENT RESULTS!
05/12/08 HERCEPTIN EVERY 3 WKS
08/22/08 BRAIN METS! 8 <5MM
09/17/08 CYBERKNIFED BRAIN METS
10/20/08 BRAIN METS SHRINKING
12/29/08 BRAIN SCAN SHOWS 1 LESION GONE, 7 SHRINKING & STABLE, 1MM ? SPOT
01/16/09 LIVER REOCUR-XELODA/HERCEPTIN
03/02/09 BRAIN SCAN 2 LESIONS GONE, 5 STABLE, 1MM ? SPOT STILL A ?
3/27/09 REGRESSION OF 2 LIVER LESIONS XELODA & HERCEPTIN
06/08/09 STUPID BRAIN HAS 3 LESIONS
06/29/09 CYBERKNIFE
07/01/09 LIVER REGRESSION NO NEW METS
07/07/09 TYKERB XELODA HERCEPTIN
11/11/09 GEMZAR/HERCEPTIN FOR LIVER PROGRESSION
03/22/10 BRAIN MRI GOOD-3 SMALL NECROSIS LEFT FROM ORIG 11!!
03/26/10 CHANGE TO NAVELBINE/HERCEPTIN 3 LIVER LESIONS PROGRESSING IN SIZE
05/21/10 NAVELBINE/HERCEPTIN WORKING!
07/19/10 GOOD BRAIN MRI
08/20/10 LIVER PROGRESSION
09/08/10 TDM1 - NASHVILLE TN
01/10/11 LIVER RESPONDING TO TDM1
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Old 06-14-2010, 12:44 AM   #10
pibikay
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Re: Chemo AND Tykerb & Herceptain??

After the treatment on 9th of Taxotrene,Zolefest and Herceptin she has lost her appetite and taste.But the flushing of the cheeks is less.But she continues to have cramps
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huband of Hema
Metstatic Breast Cancer Stage 4
Left breast cauliflower 25x20cm
ossousmetstatis in vertbrae secondaries L4=L5secondary
nodules in both liver lobes secondary
Diagnosed 10th March 2010
ER/PR-ve
Her 2 neu +++
Taxotrne Zylotec started 16th March
Herceptin added 5th April.9th Herceptin over on 20th Sep '10.Started on Tykerb and Xeloda on 22nd Oct2010TYKERB 4 TAB A DAY XELODA 4 TAB A DAY ONE WEEK ON ONE WEEK OFFZoletrust infusion every 4 months.Lesion in Brain 3D CRT Radiation started on 1st Feb'12 for 20 days ,5 days a week for 4 weeks.Devloped a small lump in breast.Xeloda stopped from 11th April '12.On Taxol.After 3 cycles of Taxol Taxol stopped.Back to Xeloda regime from 3rd July
Herceptin started again on 27th Dec 2012.Xeloda stopped Navelbin added on 7th February 2013.Now on Tykerb Herceptin and Navelbin
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Old 06-17-2010, 07:51 PM   #11
hutchibk
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Re: Chemo AND Tykerb & Herceptain??

You can drop the Tykerb doseage to 3 pills (we dropped me to 4) and see if that helps with cramps/diarrhea. I really worked for me. 5 is too many for most folks with Herceptin.
__________________
Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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Old 06-18-2010, 07:27 AM   #12
Sandra in GA
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Re: Chemo AND Tykerb & Herceptain??

Brenda,
You are so right. When I was in the phase II trial at Mayo, the protocal for the trial had already been dropped to 750 mg per day. When I was taking the Taxol along with the Herceptin and Tykerb, my dose had to be lowered to 500mg per day. Then when I was on just the Herceptin and Tykerb, the goal was a 1000 mg per day, but my onc decided we would go back to 750 and then to 1000 if my body did OK. I stayed at 750 until I finished.
Sandra
__________________
Diagnosed: 7/25/08 ~ age 63, no family history
Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
Vaccine: Walter Reed GP2/AE37 vaccine study ~ last booster 9/17/2012
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Old 06-18-2010, 11:47 AM   #13
Delaney
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Re: Chemo AND Tykerb & Herceptain??

I did the Altto trial. Took 6 tyverb pills a day for a year, absolutely no side effects. I was only off them a couple of weeks when the cancer went crazy and I ended up stage iv. dont think tyverb is strong enough on its own. am putting my faith in herceptin now.
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Delaney, dx 2008 lumpectomy,mastectomy,a/c,paxitaxol, tyverb 1 yr.
dx 2010 mets lymph nodes, skin, lung. start taxotere/herceptin.
Stopped taxtere/herceptin, now on tyverb/xeloda.
Lung mets shrinking.
Back on Herceptin with T/X. Partial response.
Skin mets progressing. Radiation scheduled mid february 2011.
Spot found on hip - radiation to hip beginning mid February 2011.
Now trying Gemzar/Tyverb/Herceptin and Zometa.
CT scan Feb 2011 - lung clear!
Brain mets (specks) - radiation mid Feb.
Brain Scan June'11 - Clear
CT Scan June'11 - Good - skin met active - watch and wait.
Surgery to remove skin met. Surgery to back 2012, four titanium rods inserted. Skin mets reappear. On Navelbine, not working. 4 week washout, start Myocet for skin and lung mets August 2012. Brain scan clear despte intermittent blurry vision (something hiding? Am suspicious but hopeful. )On we go, glad to be here.
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Old 06-22-2010, 01:09 PM   #14
my2boys
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Re: Chemo AND Tykerb & Herceptain??

I just started Tykerb daily with weekly Herceptin and Taxol. I finished A/C and waited 2 weeks before beginning the Taxol, Tykerb and Herceptin.

I will do weekly Taxol for 12 weeks and then continue on with Tykerb daily for one year and Herceptin indefinitely.
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Old 10-10-2010, 04:45 AM   #15
msleslie
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Re: Chemo AND Tykerb & Herceptain??

I'm on taxotere, carboplatin, and herceptin along with 3 Tykerb pills daily. This has been the first week that I have experienced the severe stomach cramps & diarrhea due to the Tykerb. Not sure what is going on but I hope it is better soon.
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6/14/2010 - Self discovered Lump; Age 39
6/24/2010 - Biopsy results confirm breast cancer
Right breast, invasive ductal adenocarcinoma
HER2neu positive, BRAC I & II negative
7/8/2010 - Lumpectomy right breast, sentinel lymph node biopsy, & port-a-cath installed on left
Stage II, Size 3.2cm, Clear Nodes, Clear Margins
8/19/2010 - Chemo begins - Taxotere, Carboplatin, Herceptin & Tykerb all simulanteously; ALTTO trial arm 4
9/9/2010 - Chemo dose #2
9/30/2010 - Chemo dose#3
10/21/2010 - Chemo dose#4
11/11/2010 - Chemo dose#5
12/02/1010 - Chemo dose #6 - WooHoo, it is complete!
12/14/2010 - Simulation & Planning session for radiation
02/18/2011 - Completed radiation treatment (33 rounds)
08/04/2011 - Completed Herceptin & Tykerb
09/30/2013 - ultrasound guided biopsy (following annual MRI)
10/1/2013 - new cancer in left breast. 6mm discovered via MRI
10/28/2013 - bilateral mastectomy - no reconstruction
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Old 10-16-2010, 05:11 PM   #16
shonda
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Re: Chemo AND Tykerb & Herceptain??

Well I am doing Ixempra and Tykerb now. I have had 2 rounds and I am doing well. The first round was rough, but not so sure now it was Ixempra for sure. I am holding my 3rd round for 2 weeks so I can have my ovaries out next week. So if needed Ixempra is another option with Tykerb or alone.
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Old 10-26-2010, 12:07 AM   #17
pibikay
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Re: Chemo AND Tykerb & Herceptain??

Hema is now on Tykerb 4 Tablets a day 2 after food in the morning and evening along with a similar dose of Xekoda. Xeloda a break for a week after 2 weeks but tykerb to continue
__________________
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huband of Hema
Metstatic Breast Cancer Stage 4
Left breast cauliflower 25x20cm
ossousmetstatis in vertbrae secondaries L4=L5secondary
nodules in both liver lobes secondary
Diagnosed 10th March 2010
ER/PR-ve
Her 2 neu +++
Taxotrne Zylotec started 16th March
Herceptin added 5th April.9th Herceptin over on 20th Sep '10.Started on Tykerb and Xeloda on 22nd Oct2010TYKERB 4 TAB A DAY XELODA 4 TAB A DAY ONE WEEK ON ONE WEEK OFFZoletrust infusion every 4 months.Lesion in Brain 3D CRT Radiation started on 1st Feb'12 for 20 days ,5 days a week for 4 weeks.Devloped a small lump in breast.Xeloda stopped from 11th April '12.On Taxol.After 3 cycles of Taxol Taxol stopped.Back to Xeloda regime from 3rd July
Herceptin started again on 27th Dec 2012.Xeloda stopped Navelbin added on 7th February 2013.Now on Tykerb Herceptin and Navelbin
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