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Old 10-14-2010, 09:19 AM   #41
chrisy
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Re: Liver Enzyme ?

And no, Pink I'm not suggesting you get them retested because I'm worried, but because you are!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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Old 10-14-2010, 06:42 PM   #42
Mary Jo
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Re: Liver Enzyme ?

and I'm still hanging on the theory that the bee ate the tylenol.
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"Be still and know that I am God." Psalm 46:10

Dx. 6/24/05 age 45 Right Breast IDC
ER/PR. Neg., - Her2+++
RB Mast. - 7/28/05 - 4 cm. tumor
Margins clear - 1 microscopic cell 1 sent. node
No Vasucular Invasion
4 DD A/C - 4 DD Taxol & Herceptin
1 full year of Herceptin received every 3 weeks
28 rads
prophylactic Mast. 3/2/06

17 Years NED

<>< Romans 8:28
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Old 10-14-2010, 09:46 PM   #43
Melissa
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Wink Re: Liver Enzyme ?

Hello Pink Girl,

Don't worry just yet. I posted, oh let me see, about two years ago with the same question. A few others also posted. Anyway come to find out, Arimidix can cause high liver enzymes in 2% of patients. My oncologist switched me to Femara and mine went down. I had other complications on Femera so I switched back and low and behold the liver enzymes are elevated again. Best Wishes - Mel
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04/06, (42), 2cm tumor, 7/13 nodes, one positive node under clavicle
mastectomy/reconstruction
grade 3, stage lllb, er-65+, pr-90+, her2+++(80%)
4/AC, 12wks TH then 6wks rads
40 wks herceptin, and tamoxifen.
onc test tamoxifen resistance = poor metabilizer
04/07 ooph & on arimidex
08/07 completed herceptin

04/2022 - 16 year survivor!
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Old 10-15-2010, 06:39 AM   #44
PinkGirl
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Re: Liver Enzyme ?

Thanks Melissa. I'll ask my oncologist about this ... that would be an easy solution.

Thanks MaryJo ... those bad bees!
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Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 10-15-2010, 01:19 PM   #45
Mary Anne in TX
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Re: Liver Enzyme ?

Those bees beez bad, but they make sweet honey!
You tell that body of yours to stop messing with the bees!
Luv U, ma
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Grateful for each and every day....

Diag. 12/05 at age 60
Stage II, Grade 3, 4.5 cm primary tumor
ER/PR- Her2 +3 strongly positive
Her2 by FISH 7.7 amplified
vascular invasion
Ki67 20% borderline
Jan - March '06 Taxotere/Adriamycin X 3 to try to shrink tumor - it grew
April '06 Rt Modified Radical Mas, 7 of 9 nodes positive
April - Aug. '06 Herceptin/Taxol/Carboplatin X 8 (dose dense)
Sept - Dec. '06 Navelbine/Herceptin x 8 (dose dense)
Radiation & Herceptin Jan. 22 - March 1, 2007
Finished Herceptin Dec. 10 '08! One extra year.
Port removed August, 2012.
8 1/2 years since diagnosis! 5 1/2 Years NED!
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Old 10-15-2010, 02:50 PM   #46
Rich66
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Re: Liver Enzyme ?

Wait. Are we talking multiple varieties of spray cheese?
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Old 10-15-2010, 05:26 PM   #47
Joan M
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Re: Liver Enzyme ?

Pink,

Perhaps the elevated liver enzymes are related only to your bad cold. I think they react more than we know, and then we just happen to get tested.

I'm keeping my fingers crossed that all the driving was for nothing except your mini-vacation.

Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2021 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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Old 10-16-2010, 08:29 AM   #48
PinkGirl
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Re: Liver Enzyme ?

Thanks Joan ... I hope you're right.

Yes Rich, we are talking multiple varieties. I can't mention the names of the people who managed to get the spray cheese across the border (fear for their safety). I received three different flavours. Thanks again Sheila and DonnaD.
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PinkGirl

Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

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Old 10-16-2010, 06:53 PM   #49
sassy
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Re: Liver Enzyme ?

Would this be the bees cheese?
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Rhonda (Sassy)
dx age 45
DX 2/15/05 Stage IIb (at surgery)restaged IIIa
Left mast .9cm tumor 5 of 14 nodes
Triple Positive
4 DD A/C
12 Taxol/Herceptin
33Rads
Strange infect mast site one year aft surg, hosp 1 wk
Herceptin for total of 18 months
Lupron Monthly 4 yrs
Neurontin for aches, pains and hot flashes(It works!)
Ovaries removed 11/09 stop Lupron and Neurontin
Arimidex 6 yrs (tried Femara, no SE improvement)
Tried Exemestane-hips got so bad could hardly walk
Back to Arimidex for year seven
Zometa 2X Annual for 7years, Lasix
Stop Arimidex 5/13
Stop Zometa 7/13-Bi-lateral Stress Fractures in Femurs from Zometa
5/14 Start Tamoxifen
3/15 Stem cell transplant to stimulate femur bone growth/healing
5/15 Complete fracture of right femur/Titanium rods both femurs
9/16 Start Evista stopTamoxifen
3/17 Stop Evista--unwelcome side effects!
NED and no meds.......
14YEARS NED!
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Old 10-16-2010, 07:07 PM   #50
Del
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Re: Liver Enzyme ?

Hi Pink,
My enzymes were around 70 (I don't know which one) about a month ago, and I had just had the flu 2 weeks before, so I'm betting on the cold/flu. Now my latest measurement has them at 200 (Yikes!!), but I'm now on T-DM1, but still not sure why they're so elevated...Hope you find answers soon! But try not to worry in the meantime, I don't think your numbers are that high.
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diagnosed April, 2007, age 36 - stage IV, mets to liver; ER+ (slightly), PR-, HER2+
MRM April 26, 2007
started chemo May 25, 2007 - Taxotere and Herceptin
finished chemo Oct 2007, continue on Herceptin for life, also on Tamoxifen
MRI in Jan 2008 shows no evidence of cancer in liver - NED!!
recurrence in left axilla nodes April 2010
now highly ER+, still HER2+
oophorectomy July 2010
start TDM1 (Emilia) trial Sept 2010
it's working!! can still palpate small node in axilla, but remain NED everywhere else
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Old 10-23-2010, 05:58 AM   #51
Sheila
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Re: Liver Enzyme ?

Pink Girl
If you find out the spray cheese did it, then we need to figure out which flavor, and put it on the new do not send list.....until then ( and I am confident that it will be nothing), take 2 smarties and call me in the morning.

just wanted to let you know I am thinking of you and keeping you in my prayers!
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is fighting some kind of battle."



Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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Old 10-23-2010, 07:37 AM   #52
PinkGirl
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Smile Re: Liver Enzyme ?

Thanks SheilaGirl ... now you've got me thinking about spray cheese
and spray string (which I didn't eat) being banned substances in Canada ...maybe there's something to that.

Speaking of smarties ... I was eating some Canadian Rockets which are
American Smarties ... I'll have to buy some Canadian Smarties which are American M & M's ... so confusing keeping my candies straight ... but I'll do it ...

Thanks for thinking of me Sheila ... nice picture of you in the paper!
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Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

My Photo Album
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Old 10-23-2010, 04:28 PM   #53
Barbara2
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Re: Liver Enzyme ?

I think Chrisy's suggestion was a good one:
Your primary care doctor can order that test, or around here you can sometimes get them at the drugstore for $65. You may not need the ultra sound if these numbers are back to normal.

My AST at my last onc visit (September) was 45 (range 14-36); it had been 43 one other time, but it caused me to start fretting over the numbers. The other liver enzymes were up a bit too from the previous time, but still in normal range.

I had to see the family doctor for what turned out to be a gall bladder issue; she ran the liver enzymes, and the AST was back in the normal range. It made the miserable gall bladder trip all worthwhile!
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Blessings and Peace,
Barbara

DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.

Accepting the gift of life, I give thanks for it and live it in fullness.

Last edited by Barbara2; 10-23-2010 at 04:30 PM..
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Old 10-23-2010, 06:01 PM   #54
Mary Jo
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Re: Liver Enzyme ?

and on that note, I just had my gall bladder removed on Oct. 20th. While doc was in their, of course, got a great look at my liver and said it looked EXCELLENT. Yippee!

Mary Jo
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"Be still and know that I am God." Psalm 46:10

Dx. 6/24/05 age 45 Right Breast IDC
ER/PR. Neg., - Her2+++
RB Mast. - 7/28/05 - 4 cm. tumor
Margins clear - 1 microscopic cell 1 sent. node
No Vasucular Invasion
4 DD A/C - 4 DD Taxol & Herceptin
1 full year of Herceptin received every 3 weeks
28 rads
prophylactic Mast. 3/2/06

17 Years NED

<>< Romans 8:28
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Old 10-24-2010, 10:33 AM   #55
PinkGirl
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Re: Liver Enzyme ?

Thanks Barb and Mary Jo
My onc. wants me to have the ultra sound so I will. I still have some
remnants from my bad cold/flu thingie and next week I might be getting
my flu shot so I'm going to hold off on re-doing the blood work. I will
do that eventually.

When my husband had his gall bladder problems his liver was very
unhappy. Knowing you Mary Jo, you probably had yours out and then
got dressed and walked 3 miles home

Thanks for thinking of me.
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Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

My Photo Album
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Old 10-24-2010, 10:39 AM   #56
Mary Jo
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Re: Liver Enzyme ?

@Pink.....Hahahahahahahahaha...I am still chuckling because of your comment ........ Well, I didn't walk 3 miles home BUT I had surgery on Wed., and on Friday I did 4 loads of laundry, swiffered all the hard wood floors, vacuumed the braided rugs.....upstairs tv room and our bedroom.......vacuumed furniture and the stairway. Then later in the afternoon my hubby and I walked a mile. Today, Sunday I walked 2 miles......MAN, just typing this I realize that when my husband calls me STUBBORN (in not always so nice a tone) he may be onto something, huh?

Love to you Pink.....Stay healthy, ok? I mean it!!!!!!!!!!!!

Mary Jo
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"Be still and know that I am God." Psalm 46:10

Dx. 6/24/05 age 45 Right Breast IDC
ER/PR. Neg., - Her2+++
RB Mast. - 7/28/05 - 4 cm. tumor
Margins clear - 1 microscopic cell 1 sent. node
No Vasucular Invasion
4 DD A/C - 4 DD Taxol & Herceptin
1 full year of Herceptin received every 3 weeks
28 rads
prophylactic Mast. 3/2/06

17 Years NED

<>< Romans 8:28
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Old 10-31-2010, 12:53 PM   #57
Catherine
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Re: Liver Enzyme ?

Pinkie,

I have not been on line much to follow the post about your liver, bees and spray cheese. I just want to say hi and hope you get these questions resolved and you can just focus on your gambling. Do take care, I hope that all the health concerns disappear soon.

Hugs, Catherine
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Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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Old 10-31-2010, 02:11 PM   #58
PinkGirl
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Re: Liver Enzyme ?

Thanks very much Catherine. I had the ultra sound on Friday morning and now I have to wait to hear from my onc. Thanks for thinking of me.
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PinkGirl

Dx Aug/05 at age 51
2cm. Stage 2A, Grade 3
ER+/PR-
Her2 +++

Sept 7/05 Mastectomy
4 FAC, 4 Taxol, no radiation
1 year of Herceptin
Tamoxifen for approx. 4 months,
Arimidex for 5 years
Prophylactic mastectomy June 22/09



" I yam what I yam." - Popeye

My Photo Album
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Old 10-31-2010, 05:50 PM   #59
Bill
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Re: Liver Enzyme ?

Thinking of you here, Lady Pink. Hope all is well.
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Old 10-31-2010, 08:54 PM   #60
Mary Jo
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Re: Liver Enzyme ?

Is thinking of you Pink...

Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10

Dx. 6/24/05 age 45 Right Breast IDC
ER/PR. Neg., - Her2+++
RB Mast. - 7/28/05 - 4 cm. tumor
Margins clear - 1 microscopic cell 1 sent. node
No Vasucular Invasion
4 DD A/C - 4 DD Taxol & Herceptin
1 full year of Herceptin received every 3 weeks
28 rads
prophylactic Mast. 3/2/06

17 Years NED

<>< Romans 8:28
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