Aromatase Inhibitors: Personalized dosing?

[donocco]

Teal
I checked up on Aromatase Inhibitor doses. For your own info go to Pub Med and type in doses of Aromatase Inhibitors . Look at the 4th article. They did an experiment. The standard dose of Letrozole is 2.5mg daily. So tjhey tried othr doses. One dose was 2.5mg letrozole only on Monday, Wednesday and Friday. The second dose was 1mg daily on Monday Wednesday and Friday, and the 3rd ose was 0.25mg daily on Monday Wednesday and Friday. Even the lowest dose was effective. Print out the article.

This was one experiment. I think its going to be quite a battle getting an oncologist to try this but you can show him (her ) the info and dicuss it.

Paul

[Hopeful]

Trying to recall the name of an older thread on this board that dealt with a similar question, only it had to do with how quickly the body metabolizes a drug. As I recall it, for all drugs, there are fast metabolizers and slow metabolizers. There is a certain level of the drug that is supposed to be sustained in the body during treatment. The standard dosing for the drug is based on the clearance rate of the fastest metabolizers, in order to make sure that everyone who uses the drug gets the benefit they are supposed to from it. Unfortunately, the slower metabolizers wind up with a higher level of the drug in their body because they can't clear it as quickly. This may result in more prominent side effects from it. So, it is not just a body mass question but a metabolizing speed question to determine the optimum individual dosing.

Hopeful