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07-11-2008, 08:20 AM
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#1
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Senior Member
Join Date: Jul 2006
Location: Shingle Springs, CA - near Sacramento
Posts: 295
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Herceptin - when does the year start?
Okay, this sounds like a silly question, but my cousin called yesterday and said her physician doesn't count the two loading doses and the following three doses in the year of herceptin. This means my cousin, Kathy, needs 5 more weeks of herceptin that she wasn't counting on. I didn't complete my year due to low MUGA scores so I was not able to answer her question, but is this a normal way to count a year? I told her, in my opinion, the more herceptin the better, it's insurance. She's having some side effects she could live without and not to mention the time involved for the "extra" treatments since she doesn't live real near her treatment center.
Thanks for any help on this, I will get the information to her. Have a great day!
Donna
__________________
Donna in the Sierra Foothills of California
Diagnosed 6/7/06 invasive ductal carcinoma/ductal carcinoma in situ
Lumpectomy 6/21/06
Pathology: Er 99% Pr 10% Her2/neu 3+
DNA Index 1.0
S-Phase 3/High
Primary Tumor 2.4 cm Sentinel Node Tumor 2.1cm
A/C/T+ Herceptin + rads + Arimidex
stopped Herceptin after 7 mos. due to low MUGA
Surgery for thickened uterine tissue May 2008 - conclusion: side effect of Arimidex
Switched from Arimidex to Femara - joint/tendon problems significantly better!
2 year mark Pet scan and Echo shows all clear!
5 year mammogram with ultrasound shows no sign of cancer - yay!
11 years, 11 months new breast cancer - found lump
Mastectomy 4/30/2018
Pathology: Er99%, PR 28%, Her2 negative! (new type)
Faslodex
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07-11-2008, 08:56 AM
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#2
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Senior Member
Join Date: Jun 2007
Posts: 2,210
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My oncologist used 17 treatments as her measure. Multiplied by every 3 weeks, that amounts to one year. Well, 51 weeks.
__________________
Bonnie
Post menopause
May 2007 Core biopsy, Rt breast
ER+, Pr-, HER2 +++, Grade 3
Ki-67: 90%
"suspicious area" left breast
Bilateral mastectomy, (NED on left) May 2007
Sentinel Node Neg
Stage 1, DCIS with microinvasion, 3 mm, mostly removed during the biopsy....
Femara (discontinued 7/07) Resumed 10/07
OncoType score 36 (July 07)
Began THC 7/26/07 (d/c taxol and carboplatin 10/07)
Began Herceptin alone 10/07
Finished Herceptin July /08
D/C Femara 4/10 (joint pain/trigger thumb!)
5/10 mistakenly dx with lung cancer. Middle rt lobe removed!
Aromasin started 5/10
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07-11-2008, 09:17 AM
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#3
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Senior Member
Join Date: Aug 2006
Location: Sheboygan, WI
Posts: 2,582
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The "counting" for me began with the first infusion (the loading dose) when my taxol started. I received it every 3 weeks.
Mary Jo
__________________
"Be still and know that I am God." Psalm 46:10
Dx. 6/24/05 age 45 Right Breast IDC ER/PR. Neg., - Her2+++ RB Mast. - 7/28/05 - 4 cm. tumor Margins clear - 1 microscopic cell 1 sent. node No Vasucular Invasion 4 DD A/C - 4 DD Taxol & Herceptin 1 full year of Herceptin received every 3 weeks 28 rads prophylactic Mast. 3/2/06
17 Years NED
<>< Romans 8:28
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07-11-2008, 10:52 AM
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#4
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Senior Member
Join Date: Jun 2007
Location: moved to Lancaster, Pa in June, 2010
Posts: 576
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My onc started counting with the 2 loading doses, every three wks for a total of 52 weeks.
__________________
Debbie in North Carolina
Diag 10/2006-high grade invasive ductal carcinoma- mastectomy L breast
2.5 cm tumor ER/PR pos-Her2+++
4 rounds A/C, 4 rounds Taxol
Herceptin every 3 weeks until Jan. 2008
6/18/07 prophylatic mastectomy R breast
8/2007 started aromasin/stopped arimidex (side effects)
12/07 stopped aromasin due to side effects (now what?)
Finished herceptin 1/8/08
started tamoxifen for 2 years then will switch to femera
allergic to tamoxifen started femera 4/2008
June 20, 2008 portacath removed
Learnig to live life to the fullest!
Stopped Femera due to side effects
July 28, 2008 start trial for breast cancer vaccine
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07-11-2008, 12:24 PM
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#5
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Mine counted them all, including the first - 17 tx in total, every 3 weeks for a year.
Hopeful
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07-11-2008, 12:31 PM
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#6
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Senior Member
Join Date: Oct 2005
Posts: 823
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My first was my loading dose and then weekly there after for 51 weeks.
__________________
Vicki
Texas
Biopsy Dx'd 3-23-05 Age 48
MRM 4-5-05 w/ 2 tumor's 5cm, and 6 cm (right side)
IDC (poorly differentiated infiltrating ductual carcinoma)
5+/16 nodes
Stage III A
Grade 3
ER/PR-, Her2/neu ++
Ki67 78%
Begin Chemo 5-2-05 4XAC Dose Dense , 4X Abraxane Dose Dense (ended August 05)
28 Rad's ended October 13 2005
Started Herceptin Weekly August 2005 for one year
Had a Simple mastectomy left side after Mamo showed incresed micro-calcifications. Jan. 17 2006.
Brain MRI Feb.2006--All Clear
August 28, 2006 Last Weekly Herceptin.
October 2006--Colonoscopy, 6 Polyp's removed--all B9
PET Scan July 2007
Abdominal MRI Oct. 2007---2 Right Kidney Cysts
Core Biopsy-- Lump on Scar Line 1-10-08---B9
Brain MRI 6-2008--All Clear
PET/CT Scan 6-2008
Sept. 8 2008, 4CM area removed from mastectomy scar line. Proved to be B9.
PET/CT Scan-- July 2009 --All clear
August 17,2009 ---Had Port Removed
6 Years NED -- April 5,2011
DX'd with Melanoma left arm 10-10-2011
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07-11-2008, 01:10 PM
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#7
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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Donna
Is your cousin on the maternal side? I have been reading about a type of her2+ breast cancer which may be X-linked--inherited from mother to daughter on the X-chromosome and related to FoxP3 a gene necessary for the function of T-regulatory cells of the immune system. These familial cases seem to be of ER+her2+ breast cancer will be hard to identify as her2 status has only begun to be tested relatively recently.
Are there any other females on your mother's side with breast cancer?
Sorry to pry, but within this information may lie some answers as to how ER+her2+ breast cancer arises and how it best is treated.
Thanks for any info!
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07-11-2008, 01:21 PM
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#8
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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17 Herceptins for Me!
Hi Donna,
I had 17 treatments of Herceptin in total - including the loading dose - every 3 weeks - - so 51 weeks.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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07-12-2008, 11:05 AM
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#9
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Senior Member
Join Date: Jul 2006
Location: Shingle Springs, CA - near Sacramento
Posts: 295
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HI Lani,
Though most of the post you just made is over my head, yes, my cousin is on my mother's side. My mother also had breast cancer and a recurrence, but has been cancer free for 15 years now. We don't know what her pathology was, she didn't keep it as a record and I would assume it's too old to be on file - not that her2 would be indicated anyway.
I would be interested in information on this subject - thanks so much!
Donna
__________________
Donna in the Sierra Foothills of California
Diagnosed 6/7/06 invasive ductal carcinoma/ductal carcinoma in situ
Lumpectomy 6/21/06
Pathology: Er 99% Pr 10% Her2/neu 3+
DNA Index 1.0
S-Phase 3/High
Primary Tumor 2.4 cm Sentinel Node Tumor 2.1cm
A/C/T+ Herceptin + rads + Arimidex
stopped Herceptin after 7 mos. due to low MUGA
Surgery for thickened uterine tissue May 2008 - conclusion: side effect of Arimidex
Switched from Arimidex to Femara - joint/tendon problems significantly better!
2 year mark Pet scan and Echo shows all clear!
5 year mammogram with ultrasound shows no sign of cancer - yay!
11 years, 11 months new breast cancer - found lump
Mastectomy 4/30/2018
Pathology: Er99%, PR 28%, Her2 negative! (new type)
Faslodex
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07-12-2008, 05:34 PM
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#10
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Senior Member
Join Date: Jan 2008
Location: Madison Wisconsin
Posts: 38
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My physician counts 1 year from the first dose. I recieved Herceptin weekly with my 12 Taxols. So I will have 9 more months of every 3 week Herceptin only. Confusing isn't it?
Cheryl
__________________
10/23/07 first ever mammo turned 40
11/9 biopsy
11/12 dx ILC 1.5cm er/pr+, her2/neu+
11/20 MRI
11/30 biopsy
12/3 another ILC area 8mm
12/21 lft mastectomy with expander placement
12/26 NODES NEGATIVE! However not 2 small tumors.1 bigger one4x3x3.Also DCIS and LCIS noted.grade II,stage IIa.
1/29/08 port placed
1/31 BRCA negative
A/C Done.Taxol DONE
Herceptin every 3 weeks for 1 year
Tamoxifin for 5 years
New left Boob-7/29/08
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07-12-2008, 08:24 PM
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#11
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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Donna, I think I read your ER % was close to 90
How high was your cousin's? Was she PR+?
Here are the top threea articles (One a commentary, actually) on the topic:
:
Related Articles, LinksMedema RH, Burgering BM.
The X factor: skewing X inactivation towards cancer.
Cell. 2007 Jun 29;129(7):1253-4. Review.
PMID: 17604714 [PubMed - indexed for MEDLINE]
Related Articles, LinksZuo T, Wang L, Morrison C, Chang X, Zhang H, Li W, Liu Y, Wang Y, Liu X, Chan MW, Liu JQ, Love R, Liu CG, Godfrey V, Shen R, Huang TH, Yang T, Park BK, Wang CY, Zheng P, Liu Y.
FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
Cell. 2007 Jun 29;129(7):1275-86. Epub 2007 Jun 14.
PMID: 1757048
5:
Related Articles, LinksZuo T, Liu R, Zhang H, Chang X, Liu Y, Wang L, Zheng P, Liu Y.
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.
J Clin Invest. 2007 Dec;117(12):3765-73.
PMID: 18008005 [PubMed - indexed for MEDLINE]
To look them up go to google and enter "ENTREZ PUBMED" , then enter the PMID number of each into the rectangular bar hit go and "Voila!"
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