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09-12-2013, 03:12 PM
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#1
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Senior Member
Join Date: Apr 2011
Posts: 403
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How do you boost your platelets on Kadcyla
I was due for my 6th Kadcyla today but had to reschedule it because my platelets are only 65,000- I need 10,000 more to get the full dose. My doctor wanted to wait another week and if it still does not come back up, he will give me a reduced dose.
I have tried some herbs and sesame oil but didn't seem to work well. My nurse told me to try Crotalus Horridus - snake venum for a week.
Anyone else had similiar problems while on TDM1-Kadcyla? do you get a reduced dosage or how do you keep your platelets above 75,000? I imagine how hard this drug is for people that have been on it for years
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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09-12-2013, 05:48 PM
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#2
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: How do you boost your platelets on Kadcyla
Wondered if papaya itself would do? Be sure to check with your doctor first.
Asian Pac J Trop Biomed. 2013 Sep;3(9):720-4. doi: 10.1016/S2221-1691(13)60145-8.
Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model.
Dharmarathna SL, Wickramasinghe S, Waduge RN, Rajapakse RP, Kularatne SA, Halim SZ.
Source
Department of Pathobiology, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka.
Abstract
OBJECTIVE:
To investigate the potential role of fresh Carica papaya (C. papaya) leaf extract on haematological and biochemical parameters and toxicological changes in a murine model.
METHODS:
In total 36 mice were used for the trial. Fresh C. papaya leaf extract [0.2 mL (2 g)/mouse] was given only to the test group (18 mice). General behavior, clinical signs and feeding patterns were recorded. Blood and tissue samples were collected at intervals. Haematological parameters including platelet, red blood cell (RBC), white blood cell (WBC), packed cell volume (PCV), serum biochemistry including serum creatinine, serum glutamic-oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) were determined. Organs for possible histopathological changes were examined.
RESULTS:
Neither group exhibited alteration of behavior or reduction in food and water intake. Similarly, no significant changes in SGOT, SGPT and serum creatinine levels were detected in the test group. Histopathological organ changes were not observed in either group of mice except in three liver samples of the test group which had a mild focal necrosis. The platelet count (11.33±0.35)×10(5)/µL (P=0.000 04) and the RBC count (7.97±0.61)×10(6)/µL (P=0.000 03) were significantly increased in the test group compared to that of the controls. However, WBC count and PCV (%) values were not changed significantly in the test group. The platelet count in the test group started to increase significantly from Day 3 (3.4±0.18×10(5)/µL), reaching almost a fourfold higher at Day 21 (11.3×10(5)/µL), while it was 3.8×10(5)/µL and 5.5×10(5)/µL at Day 3 and Day 21 respectively in the control. Likewise, the RBC count in the test group increased from 6×10(6)/µL to 9×10(6)/ µL at Day 21 while it remained near constant in the control group (6×10(6)/µL).
CONCLUSIONS:
Fresh C. papaya leaf extract significantly increased the platelet and RBC counts in the test group as compared to controls. Therefore, it is very important to identify those chemicals of C. papaya leaves as it can be recommended to be used as a medication to boost thrombopoiesis and erythropoiesis in humans and in animals in which these cell lineages have been compromised.
__________________
Jackie07
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09-13-2013, 06:03 AM
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#3
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Senior Member
Join Date: Jul 2008
Posts: 186
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Re: How do you boost your platelets on Kadcyla
Since reduction of platelet count is a known side effect of kadcyla and is closely monitored by prescribing oncologists, one would think Roche, as owner of product, would've researched and published ways to minimize, and ultimately help get around this problem.
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09-13-2013, 11:53 AM
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#4
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: How do you boost your platelets on Kadcyla
Unfortunately there is no drug to boost platelets like Neupageon can boost white cell. My onco said our body has to work on its own 
I did get Crotalus Horridus and to my surprise it does not taste bad at all. It comes in tiny white sugary balls. I am taking 5 *2, strength is 12X. Will let you know if i have a magic boost next week
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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09-13-2013, 12:05 PM
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#5
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Senior Member
Join Date: Apr 2009
Location: La Quinta, Ca
Posts: 253
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Re: How do you boost your platelets on Kadcyla
I highly recommend that you print the Genentech Kadcyla dosing and administration guide available on the internet. It gives the company's guidance about what should be done when various tests are not normal. For platelets, they recommend administration be held if platelets go below 50,000. I was also told this by two oncology offices where I received Kadcyla on the expanded access program. My platelet count started at 263000 and dropped to 68,000 after 11 treatments. They have remained in the 60,000 range ever since.
I am currently on a break because my T. Bilirubin went above 1.5. I have an excel spreadsheet to follow all the lab work and scans Genentech talks about in the guide. It is very helpful to discuss my concerns with my oncologist who knows little to nothing about this drug. I am the only one on it in this rather large oncology practice. He told me on my last visit that I should have been a doctor and I took that as a compliment.
Good luck with Kadcyla. I have found it to be a difficult drug and the idea of being on this for the rest of my life is frightening.
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09-13-2013, 01:26 PM
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#6
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: How do you boost your platelets on Kadcyla
Thx Nancy. My onco planned 6 cycles of Kadcyla for me. He didn't want to reduce the dosage but if my platelets don't get to 65,000, i will have a reduced dosage next week. The plan for me is rescan after the 6th infusion. If all affected areas in chestwall is gone, he would like to put me on maintenance drug. I have had non stop chemo for 2.5 years and i am finally planning to take medical leave in Oct. How are you doing on your treatment? 11 months must be tough ! If you are stable or NED, has your doctor talked about taking you off Kadcyla?
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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09-13-2013, 02:31 PM
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#7
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Senior Member
Join Date: Apr 2009
Location: La Quinta, Ca
Posts: 253
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Re: How do you boost your platelets on Kadcyla
Yanyan,
Kadcyla is shrinking the tumor but i am not NED. Can you share the name of the maintenance drug and dosage your onc has planned? Thanks
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09-13-2013, 06:50 PM
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#8
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Senior Member
Join Date: Nov 2010
Posts: 393
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Re: How do you boost your platelets on Kadcyla
Lorraine has had a good response from beginning , some tumors disappearing after 3 doses . but had a quick plat drop. after 7 doses her plats went into 70's. she reduced to 3.0, and continued good response. just alittle slower , ned by one yr on t dm-1. then sepsis from old stents sent plats to 20's ! briefly , then 40',s , low 50's. fortunately Gen. listened to her docs , and gave her some weeks to recover.
3.0 took her to ned by nov., 2011. we do a neo-paleo diet , some red meat , greens like kale, spinach , nuts , berries, and sharks liver oil, chlorophyll from health fod store, regular rest and light exercise. in fact , a" brisk " walk before blood draw may boost plats by 10,000 , try it ! we take breaks regularly - 4, even 5 weeks. be a squeaky wheel ! hope the break gets you over 75 ! . Lorraine s plats are in high 60's to low 70's. 80's twice, 90's once this yr. after almost 3 full yrs ! we hope to go to every 4 weeks, even if we have to come off study , if our hospital allows 4 weeks. then to 2.4 next yr , if ned continues ( Praise God ). Good Luck - God continue to Bless !
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09-13-2013, 06:52 PM
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#9
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Senior Member
Join Date: Nov 2010
Posts: 393
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Re: How do you boost your platelets on Kadcyla
correction : the sepsis occurred about 6 months into tx., took long break from tx., well over a month, when tx resumed tumors kept slowly disappearing to one by 10 months , ned at a yr.
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09-13-2013, 10:59 PM
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#10
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Senior Member
Join Date: Apr 2011
Posts: 403
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Re: How do you boost your platelets on Kadcyla
So happy for Lorraine that she is still NED! Have you talked to her doctor about being on maintenance drug like perjeta with herceptin or tykerb with herceptin?
__________________
1/11 age 36 DX
ER/PR-, Her2 +
TCH*6, Herceptin
BMX with immediate recontruction 5/2011 Lattismus Flap- Dx stage 3c 10/23 nodes
9/11 Radiation
3/12 Local recurrence to skin stage IV
Whole body scan CLEAR
4/12 Tykerb & Xeolda Skin mets slowly regressing
8/12 PET & Brain CT Clear
5/13 Skin mets progressing
6/13 PET scan chestwall recurrence in contralateral anxillary,internal mammary and ipsilateral subpectoral nodes
6/13 kadcyla
10/13 whole body scan -clear NED. previously resolved skin rash gone but 3 new lesions. Biopsy confirmed for skin recurrence
11/13 to 02/14 tykerb & herceptin
02/14 add abraxane/gemzar, 2 weeks on 1 week off at reduced dose
05/14 whole body PET clear/ brain CT clear but skin mets are getting worse, ready for new chemo
05/14 navelbine perjeta herceptin
07/14 skin mets progressing red rash worse
08/14 wide local excision with diep flap to close wound. Final path shows 2 positive margins showing inflammatory carcinoma Going back to surgery in 2 weeks
09/01/14 resection- clear margins
3 weeks after 2nd surgery, a new nodular rash found near drain incision with 2 small red spots behind the chest wall biopsy on 10/1. Positive for breast cancer
Radiation 11/2014 with xeloda then weekly cisplatin
11/14 brain MRI clean
12/14 finished 33 radiations burnt and very painful. Bedridden for 1 week
12/14 t current Herceptin and perjeta only
02/15 rash on upper back right side skin mets radiation planned
02/15 staring electron radiation *35
Stopped at 30 due to severe skin burn, resumed 10 days later
05/15 red patches appeared in between previously radiated area, skin mets. Ct and brain Mri clear. Simulation planned, radiation to start after trip to Alaska.
05/24 new spot identified in scar line on previously radiated reconstructed breast- electron on both side chest wall area and scar line
07/15 multiple skin and lung recurrence begin halaven
11/15 cough much better but very tired on halaven and starting to see some new red skin blotches-suspicious
11/15 heading to China for immune therapy
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09-14-2013, 12:25 AM
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#11
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Senior Member
Join Date: Jul 2013
Posts: 260
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Re: How do you boost your platelets on Kadcyla
Dear yanyan,
Snake venom decreases platelets but I assume you are taking a homeopathic remedy. Taking a homeopathic snake venom pill is the same as taking a sugar pill, as there is no snake venom left after the homeopathic dilution. Save your money.
I assume you are eating a good nutritious diet already.
The most likely thing that will increase your platelets is giving your body that extra bit of time to recover from the last dose as your doctor has suggested.
Good luck with this.
Aussie Girl
__________________
31mm Infiltrating duct carcinoma
Grade 3, ER/PR-, HER2+, Neg Sentinel nodes x 5
49mm field of DCIS
17 June '13: Screen detected impalpable mass, Mammogram neg, US.
25 June '13: Diagnosed after multiple biopsies and MRIs
28 June '13: Left lumpectomey
4 July '13: Left Mastectomy
12 August '13: Commenced TCH chemo
Mid December '13 : TCH finished. Herceptin continuing three weekly.
4 August 2014- Herceptin infusions finished.
END OF THERAPY - YAY!
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09-16-2013, 10:39 AM
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#12
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Senior Member
Join Date: Nov 2010
Posts: 393
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Re: How do you boost your platelets on Kadcyla
we have not considered perj/herc. . possible option , but right now , stage iv at MGH / Farber seem to have difficulty getting perj. not sure why. not appr. by FFDA so they wont rock boat ?? L. has tried tyk twice, w/ xeloda - nasty gi s/e's for her . so we go with t dm-1 as it is working fine.
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