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Old 12-06-2007, 08:53 AM   #1
alw
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Lani or others following the SABCS Posters

To anyone reviewing the posters for the upcoming SABCS Conference - or anyone else in the know,

I've been looking for a poster for the results of the Phase III GSK Clinical Trial involving combining Herceptin and Lapatinib (EGF104900). It doesn't appear to be on the schedule.

Just thought I'd throw this out there in case anyone has an inside source.

With warm regards,

Amy
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Amy age 37 at dx
Feb 2008 Multifocal DCIS
Apr 2008 Bilateral Mastectomies

Sister to Laura age 37 at dx
April 2006
9 cm ER-/PR- Her2 +++/bone mets
neoadjuvant TCH plus Zometa
November 2006
bilateral mastectomy - Change to ER+/PR- Her2 +++
January 2007
innumerable tiny brain mets - WBR
March 2007
good response to WBR - some gone, all smaller
currently on Lapatinib and Xeloda
Feb 2008
Brain MRI: brain mets went from innumerable (jan '07) to 5 (june '07) to 3 (oct '07) to 1 that is getting less conspicuous(feb '08) PET/CT: Slight uptake in some sclerotic bone mets
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Old 12-06-2007, 09:38 AM   #2
Joe
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Amy,
We have a meeting scheduled with GSK in San Antonio and will certainly bring that up.

Regards
Joe
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Old 01-02-2008, 08:53 AM   #3
alw
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Hello,

I was wondering if anyone was able to learn anything regarding the GSK Phase III trial combining Herceptin and Tykerb (http://clinicaltrials.gov/ct2/show/N...uzumab&rank=10)?

It was a larger study (270) and began in Nov 2005. Clinicaltrials.gov indicates that it is ongoing but not recruiting. Some GSK literature indicated that preliminary results would be available Quarter 3 of 2007.

I know that Nancy Lin at Dana Farber has a current Phase II study (NCT00470704) that started in May of 2007.

And there are a number of others that are new or not yet started that include Herceptin and/or Tykerb plus a Taxol or other agent.

Any insider information would be greatly appreciated.

Regards,

Amy
__________________
Amy age 37 at dx
Feb 2008 Multifocal DCIS
Apr 2008 Bilateral Mastectomies

Sister to Laura age 37 at dx
April 2006
9 cm ER-/PR- Her2 +++/bone mets
neoadjuvant TCH plus Zometa
November 2006
bilateral mastectomy - Change to ER+/PR- Her2 +++
January 2007
innumerable tiny brain mets - WBR
March 2007
good response to WBR - some gone, all smaller
currently on Lapatinib and Xeloda
Feb 2008
Brain MRI: brain mets went from innumerable (jan '07) to 5 (june '07) to 3 (oct '07) to 1 that is getting less conspicuous(feb '08) PET/CT: Slight uptake in some sclerotic bone mets
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Old 01-02-2008, 11:08 AM   #4
Lani
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didn't see it and didn't see it in late arriving posters list either

Sorry. Did anyone else? Lani
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Old 01-02-2008, 09:05 PM   #5
Lani
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the video presentation I recommended today (and described how one

navigates to it from www.sabcs.org refers briefly to the trials, no results yet
Also discusses excellent preclinical synergism.
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