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Old 04-20-2010, 12:56 PM   #1
Nancy L
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HER2-Positive Breast Cancer: Beyond Trastuzumab

This was an interesting article.

http://www.cancernetwork.com/breast-.../10165/1556186
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Old 04-20-2010, 02:53 PM   #2
Chelee
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Re: HER2-Positive Breast Cancer: Beyond Trastuzumab

Your right Nancy...it is a very interesting article. Thanks so much for posting this.

Chelee
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DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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Old 04-20-2010, 03:17 PM   #3
bejuce
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Re: HER2-Positive Breast Cancer: Beyond Trastuzumab

Yes, thanks for posting! I did find it a bit depressing though:

"Despite the major advance in the therapy of HER2-positive breast cancer represented by this agent, nearly all patients treated with trastuzumab for advanced breast cancer will ultimately experience progression, while a significant proportion of patients receiving this treatment in the setting of early breast cancer will experience disease recurrence."
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Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin


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Old 04-22-2010, 12:28 PM   #4
Rich66
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Re: HER2-Positive Breast Cancer: Beyond Trastuzumab

But...there seems to be value in continuing H after progression...with cancer stem cell implications. That's more than can be said for a lot of therapies.
I'm surprised they didn't get into the Her2/ER crosstalk issue.
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Old 04-22-2010, 08:00 PM   #5
Nancy L
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Re: HER2-Positive Breast Cancer: Beyond Trastuzumab

Rich, I would love a link to the Her2/Er crosstalk debate. Thanks
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Old 04-22-2010, 09:19 PM   #6
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Re: HER2-Positive Breast Cancer: Beyond Trastuzumab

http://her2support.org/vbulletin/showthread.php?t=38998
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