HonCode

Go Back   HER2 Support Group Forums > her2group
Register Gallery FAQ Members List Calendar Search Today's Posts Mark Forums Read

Reply
 
Thread Tools Display Modes
Old 05-22-2012, 09:07 AM   #1
AliciaB
Senior Member
 
Join Date: May 2012
Posts: 55
Her2 +++

Okay, so I need to look more closely at my path report.
But does the degree of HER2 make a difference? What about degree of Er+ and Pr+?
I know I am triple positive but .......
More scary things to worry about .....shit!
AliciaB is offline   Reply With Quote
Old 05-22-2012, 01:05 PM   #2
Becky
Senior Member
 
Becky's Avatar
 
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
Re: Her2 +++

Some pathology reports state the % positive the ER and PR is. For example, I am ER 50% and PR negative.

Some also report it much the same as Her2 - ER+++, PR++ (meaning in normal speak, ER highly positive, PR medium positive).

Does yours say anything else like the above?
__________________
Kind regards

Becky

Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia

NED 18 years!

Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
Becky is offline   Reply With Quote
Old 05-22-2012, 05:39 PM   #3
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Her2 +++

receptor status guides tx. my wife is strong her2, but we know a woman who is triple pos, who has gottten good response from her2 drugs like herc itself , and tykerb. Has used er + drugs as well. various combos for many yrs , since early 2000's . My overall advice is , if you have metastatic bc , it is by definition aggressive, so get aggressive tx at a leading research hospital, if possible. With a bc specialist ( so many see generalist oncologists ). Dont hesitate to get second opinions.
phil is offline   Reply With Quote
Old 05-23-2012, 03:40 PM   #4
tricia keegan
Senior Member
 
tricia keegan's Avatar
 
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
Re: Her2 +++

I'm highly triple pos and as Becky mentioned something like 90% er/pr/her2 but still doing well and approaching seven years out next month
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
tricia keegan is offline   Reply With Quote
Old 05-23-2012, 09:40 PM   #5
AliciaB
Senior Member
 
Join Date: May 2012
Posts: 55
Re: Her2 +++

So I looked at my path report, it does not say anything about the intensity of HER2 other than that I am positive. Does the degree or intensity of HER2 make a difference in terms of reoccurance or is positive simply positive?

I am 96% ER positive. Can't recall % on pr.
Not sure I consider my cancer metastic. I have 1/4 positive lymph node with local extension. CT ( chest?) and bone scan clear.
AliciaB is offline   Reply With Quote
Old 05-24-2012, 10:18 AM   #6
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Her2 +++

Our doc never said anything about level of her2 in 06 , at dx. But to get t dm-1 , they referred to path rpt, a "6 " on the FISH scale, w any reading above a 3 to be significant for response to herceptin t dm-1. Plus Lorraine is only her2. My hunch is that t dm-1 works best w. pure her2 overexpression, easier target ?? . May not work as well w/ some er +, pr + , mixed in. should still be tried w/ any high her2 as late stage tx. Maybe when approved , it will be used in diff. combos to hit other types of bc..
phil is offline   Reply With Quote
Old 05-24-2012, 07:35 PM   #7
AliciaB
Senior Member
 
Join Date: May 2012
Posts: 55
Re: Her2 +++

Phil- are yo the main support for your wife? Do you have children at home? I am looking to chat with a husband of a wife with bc.

Also, what is dm-1?
AliciaB is offline   Reply With Quote
Old 05-25-2012, 08:09 AM   #8
Jackie07
Senior Member
 
Jackie07's Avatar
 
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
Re: Her2 +++

Alicia,

There's some very good information about Her2+++ breast cancer listed in the Homepage. Below is the link to the portion where Her2+, Her2++, Her2+++ are explained.

http://her2support.org/her2-breast-c...s-a-treatments

T-DM1 is a new treatment 'method' for Her2 +++ breast cancer. T= Trastuzumab = Herceptin = targeted medicine for Her2 positive (+++) breast cancer

T-DM1 uses Herceptin to deliver a special 'something' directly to the cancer cells that are Her2+++, so it has less side effects and more effective. There are expanded trials available in many cancer centers. And we've been hoping it will be approved by the FDA soon. You can find more discussions on T-DM1 using the 'Search' button on top.
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2

NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement (600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa

Advocacy is a passion .. not a pastime - Joe

Last edited by Jackie07; 05-25-2012 at 02:16 PM..
Jackie07 is offline   Reply With Quote
Old 05-25-2012, 09:02 AM   #9
Rolepaul
Senior Member
 
Join Date: Jan 2012
Location: Boulder Colorado as of January 2013
Posts: 389
Re: Her2 +++

TDM-1 is Herceptin conjugated (chemically bound to) Mayastine. Mayastine is too toxic to be given IV. When tied to the Herceptin (which only binds to Her+ receptors on the cancer cells) can deliver the Mayastine directly to the cancer cells with less side effects. Herceptin is a Monoclonal Antibody (MAb) that is derived from taking Her+ cell proteins and fusing them with mammalian cells to make a cell line that makes the proteins called Monoclonal Antibodies. I did some of the first work on diagnostic MAbs back in the mid 1980s. I also did some of the first work on conjugation at the same time. So yes I do know what I am talking about. I followed HER + going to the brain after Nov 2009 when my wife Nina was found to have it. I get information that others cannot. I am not as knowledgeable about Xeloda and Tykerb as others in the pharm industry, but I am not bad. GSK corporate is 15 miles down the road and Tykerb was developed there. I have talked to the development team face to face. I think I can provide good information to those that want it. As for the French 5% brain mets for BC, the most current thought is 30% for HER+. Please test for it early as the ablve articles all attribute success to early intervention.

Paul
Rolepaul is offline   Reply With Quote
Old 05-25-2012, 11:37 AM   #10
MJsHusband
Senior Member
 
MJsHusband's Avatar
 
Join Date: Apr 2012
Posts: 87
Re: Her2 +++

AliciaB,
I am the husband of a wife with bc. Feel free to chat with me whenever. ~Greg
__________________

08/10 ~ Dx IBC, Her2+++ ER-/PR- Stage 4, mets to liver. Age 43.
08/10 ~ Began 12 weeks of Taxetere/Carboplatin/Herceptin tx
[10/10 ~ Scans show liver lesions are gone. NED!
11/10 ~ Ended chemo. Herceptin-only tx
01/11 ~ Mastectomy
03/11 ~ Radiation
07/11 ~ Reconstructive surgery
10/11 ~ PET/CT shows NED :)
01/12 ~ Malignant tumors found in uterus, cervix, fallopian tubes and lymph nodes. Dx as endometrial cancer. Stage III2c
02/12 ~Hysterectomy(all tumors removed). Back to NED.
02/12 ~ Final Herceptin treatment.
03/12 ~ Began Cisplatin/Adriamycin tx for endometrial cancer.
03/12 ~ Tumors dx her2 metastisis, not entdometrial cancer. Back to BC tx.
03/12 ~ CT scan shows NED. :)
04/12/~ Began Tykerb/Xeloda.
06/12 ~ Ended Xeloda. Continuing Tykerb. Still NED.
09/12 ~ PET/CT scans show NED. : )
04/13 ~ Rash on original breast biopsied as cancer.
05/13 ~ Surgery to remove skin and tissue around rash. Continue Tykerb.
06/13 ~ PET/CT scans show NED : )
11/13 ~ Jaundice eyes and skin. CT scan show mets to liver as well as peritoneal carcinomatosis with malignant ascites. Began Abraxane/Herceptin tx.
02/14 ~ CT scan shows NED. :)

MJsHusband is offline   Reply With Quote
Old 05-25-2012, 12:46 PM   #11
phil
Senior Member
 
Join Date: Nov 2010
Posts: 393
Re: Her2 +++

I have one young adult still at home, 24 yo son. 3 older daughters, with 5 grandch., 2 more on the way ! My first wife passed away from bc in '92. battling met. bc since '06 w/ second wife. happy to share my experience w/ you, others .
phil is offline   Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Forum Jump


All times are GMT -7. The time now is 03:46 AM.


Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021
free webpage hit counter