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Old 02-12-2014, 08:12 PM   #1
crb
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Join Date: Jan 2014
Location: South Florida
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1st round of chemo tomorrow (Perjetta/Herception and friends)

Going in for my first round of chemo tomorrow. Didn't expect to be there all day, but they said 9-3:00. Having my mom bring me lunch and I know I have a private room, but don't know what to expect at all!

Any suggestions/comments/advice? Doctor has had me on B-complex vitamins (we are hoping to ward off any peripheral neuropathy - I am a dentist, so that would be bad news), Dexamethasone today, tomorrow, and next day. Anti-nausea meds prn. Does anyone think a little xanax and/or ibuprofen would be beneficial?

Thanks so much!!
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1/17/14 Day after 44th b-day, Got dx of 2 malignancies Rt breast; ER/PgR- HER2+
1/21/14 Biopsy of spot on left; normal
1/28/14 PET scan - CLEAR!
1/29/14 BRCA normal!
1/31/14 Sentinel node biopsy
2/5/14 Nodes are CLEAR! Stage I/IIa, N0, M0
2/13/14 Start Chemo, 6 rounds for 18 weeks prior to surgery
2/28/14 Port placed
3/6/14 Chemo Round 2
3/27/14 Chemo Round 3 (halfway done!)
4/11/14 u/s shows 2cm tumor about 2x5mm now!
4/17/14 Chemo Round 4
5/8/14 Chemo Round 5 and Daughter's Birthday :)
5/27/14 Last Chemo Party - Round 6
6/17 14 Herceptin only until next Feb.
6/20/14 BMX/Immediate reconstruction DONE
6/30/14 Path report back...NED!
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Old 02-12-2014, 10:18 PM   #2
IrvineFriend
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Location: Irvine, CA (Southern CA)
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Re: 1st round of chemo tomorrow (Perjetta/Herception and friends)

First time IS a very long day. When I was infused, they put benadryl in the IV and so I slept through some of it. The infusion really is the easy part, just long and boring. I made friends with a lot of people and we started taking turns buying pizzas for the infusion room patients. Drink tons and tons of water and don't worry. I had no symptoms with my first round. Good luck!
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Live in Orange County, CA

Diagnosed with DCIS Oct. 2012

Bilateral Dec. 19, 2012
IDC, ER/PR-, Her2+++, Grade 3
Stage IIIa
15.6 cm
4/14 nodes + macrometastases
First thing each morning, I try on my bathing suit. Then, nothing worse can happen the rest of the day.
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Old 02-13-2014, 08:15 AM   #3
KDR
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Re: 1st round of chemo tomorrow (Perjetta/Herception and friends)

Hi,
Perjeta and Herceptin are ADCs, antibody drug conjugates, which constitute targeted therapy. These drugs are not considered chemo.
I like the idea that your doctor has given you the B vitamin family for neuropathy, because that is (at least for me) a side effect. However, I think the other pre-meds might be precautionary and that they won't be a mainstay in your treatment. Each of these drugs is normally a 30-minute infusion, for a total of one hour. No break needed in between drugs and neither require premedication.
The loading dose is longer and you might feel very tired afterward. It gets easier. You must be going every three weeks?
Take care, and good luck,
Karen
On P&H
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Graves Disease, became Euthyroid via Radioactive Iodine, June 2001.
Thyroid Eye Disease. 2003. Decompression surgery in 2009; eyelid lowering surgery in 2010.
Diagnosed: June 2010, liver mets. ER-/PR+10%; HER2+++.
July 2010: Begin Taxol/Herceptin. Eliminate sugar from diet. No surgery or radiation.
January 2011: NED
April 2011: Progression in liver only. Other previous affected areas eradicated. Stop Taxol/Herceptin after 32 infusions.
May 2011: Brain MRI: clear.
May 2011: Begin Tykerb daily, Xeloda twice per day for one week on, one week off, and Herceptin.
November 2011: Progression in liver. All other tumors remain eradicated.
December 2011: BEGIN TRIAL #09-093 Taxol, MCC-DM1 (T-DM1), Perjeta.
Trial requires scans every six weeks, bloodwork and infusions weekly.
Brain MRI: clear.
January 2012: NED. Liver mets, good riddance!
March 2012: NED. Developed SMA (rare blood clot) in intestinal artery and loss of sight in right eye due to optical nerve neuropathy. Resolved when Taxol removed this month.
Continue Protocol of T-DM1 weekly and Perjeta every 3 weeks.
May 2012: NED.
June 2012: Brain MRI: clear.
June-December 2012: NED.
December 2012: TRIAL CONCLUDED; ENTER TRIAL EXTENSION #09-037. CT, Brain MRI, bone scan: clear. NED.
January-March 2013: NED.
June 2013: Brain MRI: clear. CEA upticking; CT shows new met on liver.
July 3, 2013: DISASTER STRIKES during liver ablation: sloppy surgeon cuts intercostal artery and I bleed out, lose 3.5 liters of blood, have major hemothorax, and collapsed lung requiring emergency resuscitative thoracotomy, lung surgery, rib rearrangement and cutting deep connective tissue, transfusion. Ablation incomplete. This life-saving procedure would end up causing me unforgiving pain with every movement I make, permanently, otherwise known as forever.
July 26, 2013: Try Navelbine/Herceptin. Body too weak after surgery and transfusion. Fever. CEA: Normal.
August 16, 2016: second dose Navelbine/Herceptin; CEA: Normal. Will skip doses. Watching and waiting.
September 2013: NED, Herceptin only. CEA: Normal. Started Arimidex.
October-November 2013: NED. Herceptin and Arimidex. CEA, CA125, 15-3: Normal.
December 2013: Something brewing. PET lights up on little spot on liver; CEA upward trend, just outside normal. PET and triphasic liver scan confirm Little Met. Restart Perjeta with Herceptin, stay on Arimidex. Genomic sequencing completed for future treatments, if necessary.
January 2014: Ablate Little Met on the 6th. Happy New Year.
March 2014: Brain MRI: clear. PET/CT reveal liver mets return; new lung mets. This is not funny.
March 2014: BEGIN TRIAL #10-005 A(11)-Temsirolimus plus Neratinib.
April 2014: Genomic testing indicated they could work, they did not. Very strange drug combo for me, felt weird.
April 2014: Started Navelbine and Herceptin. Needed something tried and true, but had significant progression.
June 2014: Doxil and Herceptin.
July 2014: Progression. Got nothing out of it. Brain: NED.
July 2014: Add integrative medical hematologist-oncologist to my team. Begin supplements. These are tumor-busting, immune system boosters. Add glutathione, lysine and taurine IV infusions every three weeks.
July 2014: Begin Gemzar, Herceptin & Perjeta. Happy.
August 2014: ECHO perfect.
January 2015: Begin weekly Vitamin D Analog infusions. 25 mcg. via port.
February 2015: CT: stable.
April 2015: Gem working, but not 100%. Looking into immunotherapy. Finally, treatments for the 21st century!
April 2015: Penn Medicine. Dendritic cell immunotherapy.
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Old 02-13-2014, 09:29 AM   #4
jaykay
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Re: 1st round of chemo tomorrow (Perjetta/Herception and friends)

The first time is a long day - they will take blood and won't start the chemo until your bloodwork comes back. Then, as Julie says, pre-meds - Benadryl makes for a great nap!. And, of course, you have to wait for the pharmacy to prepare the drugs.

Each chemo is an hour, loading dose of Herceptin is an hour and I don't know about Perjeta.

Take an electronic toy - ipad or other device. Most centers have free Wi-Fi. And reading material.

As has been mentioned - drink, drink, drink.

Good luck - the anticipation of the first time is worse than the actual experience.

Best,
Janis
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March, 2000: 48, Post menopausal (5 yrs HRT) Left breast, IDC 3mm/DCIS 1.6cm, ER+/PR-/Her2+++, mod differentiated, MIB low, lumpectomy, node neg via SNB, rads=33 Stage 1a
June, 2000: Tamox 4.5 years,Femara for 5 years (end in Jan. 2010)
Sept, 2012: 61, Via mamm, ultrasound, biopsy, right breast, 2.3cm tumor, ER+/PR-/Her2+++, poorly diff, KI67 60-70%
BRCA 1 and 2 negative
October, 2012: Bi Mast with tissue expanders, port placement
Final Path: IDC 2.8cm, DCIS, 1/4 sentinal nodes positive (@#$%). Stage IIB
Nov 29, 2012: Begin TCH/6x/every 3 wks, H for 1 year/every 3 weeks.
March 14, 2013: Finished chemo
April 9, 2013: Begin radiation 28x
May 22, 2013: Finished rads
June 1st, 2013: Started Aromasin for 5 yrs.
July 15, 2013: Switched to Letrozole (Femara). Probably for the rest of my life
October 16, 2013: Exchange surgery
October 31, 2013: Finished Herceptin
December 5, 2013: Port removed
Glad this year is over!
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Old 02-14-2014, 08:21 PM   #5
Jean
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Re: 1st round of chemo tomorrow (Perjetta/Herception and friends)

crb,
Wear soft comfy clothing, layers are best. The treatment rooms tend to be cool. Don't drown yourself with drinking water, but do hydrate yourself to flush your system. 8 cups of water is good.
Eat smaller lighter meals that are protein rich.
Now you are a dentist so you will already know to change your tooth brush frequently during treatment. The mouth area changes with treatment and mouth sores can be an issue. So keep bacteria at a low by changing your brush often. I also found that yogurt during treatment not only was a good source of protein but also provided a ph balance for mouth and stomach and gut. As the others have mentioned it is a long day so go prepared for a long visit. Take a good book which can absorb your attention. I find reading relaxing.
Good Luck tomorrow. The unknown is the most draining part of the treatment. Once treatment begins you can begin to unwind a bit.
Kind Regards,
Jean
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Stage 1, Grade 1, 3/30/05
Lumpectomy 4/15/05 - 6MM IDC
Node Neg. (Sentinel node)
ER+ 90% / PR-, Her2+++ by FISH
Ki-67 40%
Arimidex 5/05
Radiation 32 trt, 5/30/05
Oncotype DX test 4/17/06, 31% high risk
TOPO 11 neg. 4/06
Stopped Arimidex 5/06
TCH 5/06, 6 treatments
Herceptin 5/06 - for 1 yr.
9/06 Completed chemo
Started Femara Sept. 2006
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