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01-25-2010, 08:59 PM
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#21
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Senior Member
Join Date: Sep 2005
Location: Stockton, NJ
Posts: 4,179
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Re: This wk things could change, I'm nervous.
I'm there in your corner Chelee. I am sure your scans will show some improvement. Keep us posted.
__________________
Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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01-25-2010, 11:35 PM
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#22
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: This wk things could change, I'm nervous.
Will you be bringing that funky walker to your appointment?
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01-26-2010, 08:20 AM
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#23
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Senior Member
Join Date: Feb 2008
Location: Georgia
Posts: 1,486
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Re: This wk things could change, I'm nervous.
Chelee,
Wondering how you are this morning. Hope you post soon.
Amelia
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01-26-2010, 02:16 PM
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#24
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Re: This wk things could change, I'm nervous.
Chelee
Thinking of you. Hugs. Michka
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex
12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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01-26-2010, 05:48 PM
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#25
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Re: This wk things could change, I'm nervous.
Becky, I don't want my scans to show "some" improvement...I want them to show TOTAL NED improvement. lol  I'm not asking for too much am I. My last TM's were down again...they have dropped to 23 which is good. So adding the Navelbine has helped...I just hope it's done a good job?
Lori & Ellie, I'm glad you both caught my question about the best approch for attacking when your stage IV? It seems to me they "use" to hit it hard...but now they all talk about how it's not curative at this point so it's all about the QOL. Which that is important to me...but it would be nice to hit it hard enough that I could get lucky enough to have some NED time again. I've also been hearing they like to save the big guns for later if it becomes necessary. My main concern is not going so easy on "it" that it gets more time to spread. Has anyone else heard their onc feelings on this topic? Especially once stage IV.
Rich, No I won't be bringing my funky walker. lmao I'll have you know I've moved up to a funky cane!  It comes in handy for hitting people. lol
Tomorrow is the big day...don't forget to be sending those good thoughts & prayers...I sure need them. My scanxiety is off the charts today...I can imagine how I'll feel in the morning.
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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01-26-2010, 06:11 PM
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#26
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Senior Member
Join Date: Dec 2008
Location: Southern Indiana
Posts: 455
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Re: This wk things could change, I'm nervous.
Chelle,
Have I ever told you I love your picture? Sometimes I feel just like that all day long! lol
Praying for your scans tomorrow.
Hugs and blessings, Alice
__________________
Alice
04/08 age 50 III IBC Her2+++ ER/PR-8cm 14/14 Double M, Body and Brain CT/PET clear, ? on spine,Muga 53
06/08, 4 A/C, Neulasta
08/08, Herceptin/tax 12 every week
10/08, CT/PET clear, ? on pelvis, hips, MUGA 43, started Enalaprial for heart, Herceptin every 3 weeks
11/08 33Rads; 12/08 MUGA 48
2/09 MRI spine and bone scan, old mets to spine, Chest x-ray, blood work, IV NED,regular CPAP use,Zometa x6, first -flue like symptoms 2 days;Herceptin x3; stage 2 lymphoedema..sleeve and glove
4/09 Brain MRI - CLEAR; MUGA 54
7/09 chest ultrasound,
10/09 PET, brain and spin MRI NED Herceptin only. MUGA 59!!!
1/11 Hip replacement 7/11 Hip 2 replacement
4/12 4 years!! Herceptin
6/12 start reconstruction finish in 12/12
2/14 Herception - 6 years!!!
1 Corinthians 10:13 "No temptation has seized you except what is common to man. And God is faithful; he will not let you be tempted beyond what you can bear. But when you are tempted, he will also provide a way out so that you
can stand up under it."
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01-26-2010, 07:29 PM
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#27
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Senior Member
Join Date: Jan 2007
Location: Thornhill, Ontario
Canada
Posts: 2,320
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Re: This wk things could change, I'm nervous.
Good luck tomorrow Chelee.
all the best
caya
__________________
ER90%+/PR 50%+/HER 2+
1.7 cm and 1.0 cm.
Stage 1, grade 2, Node Negative (16 nodes tested)
MRM Dec.18/06
3 x FEC, 3 x Taxotere
Herceptin - every 3 weeks for a year, finished May 8/08
Tamoxifen - 2 1/2 years
Femara - Jan. 1, 2010 - July 18, 2012
BRCA1/BRCA2 Negative
Dignosed 10/16/06, age 48 , premenopausal
Mild lymphedema diagnosed June 2009 - breast surgeon and lymph. therapist think it's completely reversible - hope so.
Reclast infusion January 2012
Oopherectomy October 2013
15 Years NED!!
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01-26-2010, 08:09 PM
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#28
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Senior Member
Join Date: Oct 2007
Location: Portage, IN
Posts: 198
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Re: This wk things could change, I'm nervous.
Chelle Good luck tomorrow. I am praying for good results.
__________________
10/15/07: Diagnosed at age 46 lymph node removal (2)
ER/PR - Her2 +++
11/07: Port Installed
11/07 - 1/08: AC
1/30/08: Right Mast Stage lllC
2/28/08: Start Taxol and Herceptin weekly.
5/15/08: Finished Taxol
8/12/08: Finished 33 Rads
1/29/09: Finished Herceptin
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01-26-2010, 08:42 PM
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#29
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Senior Member
Join Date: Jun 2009
Posts: 343
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Re: This wk things could change, I'm nervous.
Sending you positive vibes for a NED scan tomorrow!
__________________
Vicky
Age 47, TN, Diagnosed 05/09
Her2+, ER/PR-, Stage III, 2 tumors = 1 8cm tumor
Grade 3
Sentinel Node Biopsy-speck present in 1 node
Completed 3 month clinical trial of weekly Herceptin and 1000mg Tykerb daily
Tumor no longer present
Right mastectomy and lymph node removal 09/25/09
No cancer present at time of surgery, none in lymph nodes
Start TCH 10/15, every 3 weeks for 4 months followed by radiation
Finished chemo 01/28/10-YEAH!
Herceptin every 3 wks until end of June
Radiation begins 03/01, 6 1/2 weeks
Radiation complete--Yeah!!
Developed lymphedema after radiation
In hospital for 4 days with pneumonia:(
Herceptin done! 06/24/10
Port Removed 07/08/10
Still in PT for lymphedema and mobility issues
DIEP Reconstruction 05/11
I can be changed by what happens to me, but I refuse to be reduced by it~~Maya Angelou
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01-27-2010, 12:28 AM
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#30
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: This wk things could change, I'm nervous.
No walker? I guess you graduated. You make it sound like you're "House MD".
If need be, you could reasonably add Xeloda to Navelbine. Maybe some Femara as well, since having Herceptin may have bosted the "weak" ER side of things. Could also go for a Her 2 blockade by adding Lapatinib. Might be worth asking for a serum her2 level and cell search to get a view on things.
Navelbine (w/Traz, liver friendly, w/Cap)
http://her2support.org/vbulletin/showthread.php?t=42261
Letrozole
(monotherapy, with chemo, w/Sorafenib, in er-, immuno-synergy, on-off strategy resensitizes)
http://her2support.org/vbulletin/showthread.php?t=43285
ER/Her2 crosstalk (combination therapies etc):
http://her2support.org/vbulletin/showthread.php?t=38998
Lapatinib/Herceptin combination (Her-blockade, Lap passes BBB)
http://her2support.org/vbulletin/showthread.php?t=41397
Circulating Tumor cell test (interpreting, vs marrow)
http://her2support.org/vbulletin/showthread.php?t=41709 |
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01-27-2010, 04:59 AM
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#31
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Senior Member
Join Date: Jun 2009
Location: Mississippi
Posts: 253
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Re: This wk things could change, I'm nervous.
Hi Chelee,
It's the big day. Have you in my prayers today.
__________________
4/09 suspicious lump in left breast
5/09 biopsi lead to diagnosis ER/PR -
Her2+.Grade 3,full masectomy left breast,sentinel nodes clear,Stage 1
6/09 Adriamycin + Cytoxan 4 treatments (every 3 weeks) followed by Taxol + Herceptin, 1 treatment weekly for 12 weeks, followed by Herceptin for 40 weeks
MRI Brain 4/10 clear
CT Body 4/10 clear
PET Body 2/11 clear
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01-27-2010, 09:13 AM
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#32
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Senior Member
Join Date: Feb 2008
Location: Bayarea,CA
Posts: 679
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Re: This wk things could change, I'm nervous.
Adding my prayers for you, Chelee!
hugs,
shobha
__________________
DX: 06-30-2007 - left breast -stage IIIB, Her2/Neu 3+++, ER weakly positive, PR-
Taxol+herceptin weekly for 3 months
FEC+herceptin every 3 weeks for 3 months
BRCA 1 and 2 - Negative
Jan 2008 - Bilateral mastectomy, prophylactic Rt. side.
Radiation for 5 weeks
Completed my yr of herceptin on 07-14-2008
Brain MRI - 3/2/09 Clean
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01-27-2010, 11:10 AM
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#33
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Re: This wk things could change, I'm nervous.
Chelee,
I also have a pet/ct today...hoping we both get fabulous news.
I agree, the liver pain could have nothing to do with cancer - the only time I EVER had any was right after my first TDM1 dose - and I'm convinced that was screaming cancer cells
Holding good thoughts for everyone...
chris
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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01-27-2010, 11:14 AM
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#34
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Senior Member
Join Date: Feb 2008
Location: Georgia
Posts: 1,486
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Re: This wk things could change, I'm nervous.
Chelee and Chrisy,
Hope you both have good results today.
Amelia
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01-27-2010, 11:23 AM
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#35
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Senior Member
Join Date: Jun 2009
Location: Mississippi
Posts: 253
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Re: This wk things could change, I'm nervous.
Ditto Chrisy.
Rooting for you both!
__________________
4/09 suspicious lump in left breast
5/09 biopsi lead to diagnosis ER/PR -
Her2+.Grade 3,full masectomy left breast,sentinel nodes clear,Stage 1
6/09 Adriamycin + Cytoxan 4 treatments (every 3 weeks) followed by Taxol + Herceptin, 1 treatment weekly for 12 weeks, followed by Herceptin for 40 weeks
MRI Brain 4/10 clear
CT Body 4/10 clear
PET Body 2/11 clear
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01-28-2010, 12:36 PM
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#36
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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Re: This wk things could change, I'm nervous.
Chelee and Chrisy, just wanted to add my prayers and good wishes for a good result for both of you
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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01-28-2010, 02:15 PM
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#37
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Senior Member
Join Date: Apr 2006
Location: Wilmington, Del.
Posts: 1,126
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Re: This wk things could change, I'm nervous.
Today is the day and I'm thinking of you, Chelee. Expecting the best, but no matter what I know you will be out there, raising Cain and keeping the medical staff on their toes.
__________________
MJO
IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
Finished Femara May 2011
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01-28-2010, 02:31 PM
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#38
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Re: This wk things could change, I'm nervous.
Chrisy, I'll be keeping good thoughts that TDM1 will continue to bring you clean scans. Which I bet it will.
The guy that was going to do my PET/CT came out to get me...and I told him how I wanted my Power Port accessed for this scan. I told him no one ever wants to use it. This lead up to me finding out my onc "only" ordered a PET scan this time. She has "never" done that! I wanted and expected a PET/CT especially since I recurred to so many areas. I wanted to see exactly what the Herceptin/Navelbine/Zometa was doing? Why would she not order the CT too?
I thought my onc was back from her vacation Feb. 2nd. But now I find out she won't return till Feb. 8th. No way am I waiting that long for the results.
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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01-28-2010, 04:32 PM
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#39
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Senior Member
Join Date: Feb 2006
Location: Southern, CA
Posts: 2,511
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Re: This wk things could change, I'm nervous.
Rich, Thanks for putting all the great links together...read them all. I appreciate it...thanks again!
Chelee
__________________
DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes.
Rt. MRM on 1-3-06 -- No Rads due to compromised lungs.
Chemo started 2-7-06 -- TCH - - Finished 6-12-06
Finished yr of wkly herceptin 3-19-07
3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07
9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV.
9-28-09 Loading dose of Herceptin & started Zometa
9-29-09 Power Port Placement
10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head.
11-19-09 RT. Femur surgery - Rod placed
12-7-09 Navelbine added to Herceptin/Zometa.
3-23-10 Ten days of rads to RT femur. Completed.
4-05-10 Quit Navelbine--Herceptin/Zometa alone.
5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy.
Results to FISH was unsuccessful--this happens less then 2% of the time.
7-7-10 Recurrence to RT axilla again. Back to UCLA for options.
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01-28-2010, 06:26 PM
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#40
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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Re: This wk things could change, I'm nervous.
Dear Chelee -
Guess your onc just wants to see how "hot" you are. I hope your PET was cold as a fish! A salmon in the Yukon River.
Too bad the lady was not there to double check on the scan orders. Mistakes do get made along the chain, as many of us so well know.
We'll be waiting right along with you. BTW - great news on the tumor marker drop. Your CA27-29 is almost the same as mine!
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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