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Brain stable, but new Torso Mets - What's Working for You?
My sister had been on CPT-11 (Irinotican) + Avastin + Herceptin since May '08, and the combination did an immediate and consistent (and miraculous) job of eliminating&stopping brain mets, so much so that her neuro-oncologist in March'09 said she could drop the CPT-11 and see how she did on Herceptin+Avastin.
But in March she had a couple of bouts of nausea, which seemed to be the flu, since her kids had it. In the last few weeks, she'd been feeling mild-mod. nausea 1x day -- MRI and brain scans clear, but CTscan of torso shows signs of early small mets in liver, pleura (membrane lining of lung), and bone in one back rib.
She remains on Herceptin and Avastin, and her oncologist added Xeloda to combat new mets in torso - will monitor closely and change chemo if Xeloda doesn't work. What have you brave and stalwart sisters found to be effective in shrinking mets in liver, pleura (lung lining) and/or bone?
Many thanks.
Emmay
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Emmay - My sister's history:
6/03 Her2+,ER-PR-Breast Cancer, IIb, 7/03 lumpec. rt.brst
9/03 Begin chemo-AC+T
2/04 Mastectomy for local recurrence
3/04 Begin Herceptin, 5/04 Rad to mastec.site
9/04 Recurring Headaches=brain mets
10/04 Craniotomy #1 - rem. 3 br. mets, 11/04 WBR
2/05 Begin Lapatinib(Tykerb) Clinical Trial
5/05 Craniotomy #2 - remove largest brain mets
7/05 Stereotactic Radiation to 2-3 brain mets
10/05 - 3/07 CyberKnife Radiation Treatments for sm brain mets as they arose. Cont. Herceptin
5/07 Begin Temodar+Sorafenib for brain mets
2/08 Begin Tykerb(Lapatinib)+Xeloda for br. mets
5/08 MRI&Biopsy shows ext.new disease, some necrosis
5/08 Begin CPT-11(Irinotecan)+Avastin for br.mets
6/08-4/09 MRIs look great! cont. Herceptin
3/09 Stop CPT-11, brain CTclear-some nausea,backpain
4/09 Scans=pleura,liver,bone mets.
New Rx Herceptin+Avastin+Xeloda
6/09 new Rx Carboplatin+Herceptin
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