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01-21-2011, 12:29 AM
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#1
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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some artificial sweeteners and probiotics may inhibit breast cancer growth(in mice)
ABSTRACT: Effects of Non-Digestible Carbohydrates on the Growth of Estrogen-Dependent Human Breast Cancer (MCF-7) Tumors Implanted in Ovariectomized Athymic Mice
[Nutrition & Cancer]
Non-digestible carbohydrates (NDC4) have been used as a low-calorie sweetener and prebiotics that stimulate the growth of certain intestinal bacteria that support healthy colon conditions. In this study, we examined the dietary effect of commercially available NDCs on estrogen receptor positive (ER+) human breast cancer. We conducted a feeding study of fructooligosaccharides (FOSs), Fibersol 2 (F2; digestion resistant maltodextrin), Hi-Maize (HM; high amylose cornstarch), and Frutafit (FF; a range of powdered inulins) (5% in diet, w/w) to evaluate their effects on the growth of ER(+) human breast cancer (MCF-7) tumors in the presence of 17β-estradiol (E2) using an athymic xenograft model. F2, HM, and FOSs supplementation significantly reduced E2-stimulated MCF-7 tumor growth by inhibiting cellular proliferation (Ki-67) and increasing apoptosis (M30) in tumors. F2, HM, and FOSs treatments also lowered serum E2 level and reduced uterine weight compared to the control diet. NDCs treatments downregulated relative mRNA expression of the E2-responsive gene markers pS2, bcl2, bcl-xL, and cyclin D1 in MCF-7 tumors. In conclusion, the NDC intake may have a protective effect against ER(+) tumors by inhibiting cellular proliferation and increasing apoptosis.
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01-23-2011, 11:41 PM
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#2
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
I would not be at all surprised if they discover xylitol to be one of those artificial sweeteners that inhibit breast cancer.
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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01-23-2011, 11:56 PM
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#3
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Senior Member
Join Date: Jan 2008
Location: "Love never fails."
Posts: 5,808
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
The citation of the article:
Kondegowda NG, Meaney MP, Baker C, Ju YH.
Nutr Cancer. 2011 Jan;63(1):55-64.PMID: 21170812 [PubMed - in process]
__________________
Jackie07
http://www.kevinmd.com/blog/2011/06/doctors-letter-patient-newly-diagnosed-cancer.html
http://www.asco.org/ASCOv2/MultiMedi...=114&trackID=2
NICU 4.4 LB
Erythema Nodosum 85
Life-long Central Neurocytoma 4x5x6.5 cm 23 hrs 62090 semi-coma 10 d PT OT ST 30 d
3 Infertility tmts 99 > 3 u. fibroids > Pills
CN 3 GKRS 52301
IDC 1.2 cm Her2 +++ ER 5% R. Lmptmy SLNB+1 71703 6 FEC 33 R Tamoxifen
Recc IIB 2.5 cm Bi-L Mast 61407 2/9 nds PET
6 TCH Cellulitis - Lymphedema - compression sleeve & glove
H w x 4 MUGA 51 D, J 49 M
Diastasis recti
Tamoxifen B. scan
Irrtbl bowel 1'09
Colonoscopy 313
BRCA1 V1247I
hptc hemangioma
Vertigo
GI - > yogurt
hysterectomy/oophorectomy 011410
Exemestane 25 mg tab 102912 ~ 101016 stopped due to r. hip/l.thigh pain after long walk
DEXA 1/13
1-2016 lesions in liver largest 9mm & 1.3 cm onco. says not cancer.
3-11 Appendectomy - visually O.K., a lot of puss. Final path result - not cancer.
Start Vitamin D3 and Calcium supplement （600mg x2)
10-10 Stopped Exemestane due to r. hip/l.thigh pain OKed by Onco 11-08-2016
7-23-2018 9 mm groundglass nodule within the right lower lobe with indolent behavior. Due to possible adenocarcinoma, Recommend annual surveilence.
7-10-2019 CT to check lung nodule.
1-10-2020 8mm stable nodule on R Lung, two 6mm new ones on L Lung, a possible lymph node involvement in inter fissule.
"I WANT TO BE AN OUTRAGEOUS OLD WOMAN WHO NEVER GETS CALLED AN OLD LADY. I WANT TO GET SHARP EDGED & EARTH COLORED, TILL I FADE AWAY FROM PURE JOY." Irene from Tampa
Advocacy is a passion .. not a pastime - Joe
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01-24-2011, 01:48 AM
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#4
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Senior Member
Join Date: May 2006
Location: Haarlem, the Netherlands
Posts: 835
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
Why xylitol? I have been hearing about avoiding artificial sweeteners. My kids are sugar intolerant so I've been looking for alternatives for years.
Chrystallized xylitol tastes good, and it's supposed to be beneficial for teeth as well.
Jacqueline
__________________
Diagnosed age 44, January 2004, 0.7 cm IDC & DCIS. Stage 1, grade 3, ER/PR pos. HER2 pos. clear margins, no nodes. SNB. 35 rads. On Zoladex and Armidex since Dec. 2004. Stopped Zoladex/Arimidex sept 2009 Still taking mistletoe shots (CAM therapy) Doing fine.
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01-24-2011, 11:54 PM
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#5
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
Xylitol has numerous health benefits. It has shown to be effective fighting bacteria for oral, nasal, and ear infections. It is also shown to prevent bone loss. Of course it is proven to be a good way to prevent cavities.
It has an impressive amt health benefits for an artifical sweeteners, and that is why I would not be surprise to read someday that it can possibly be cancer preventative.
If you google "health benefits of xylitol" you can find more info.
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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01-25-2011, 12:30 AM
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#6
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Senior Member
Join Date: May 2006
Location: Haarlem, the Netherlands
Posts: 835
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
Thanks Maryanne, I'll look into it. Pure xylitol is hard to find here in the Netherlands, but I bought to bags in France last summer. Will need to go there again. Good excuse for a trip!
Jacqueline
__________________
Diagnosed age 44, January 2004, 0.7 cm IDC & DCIS. Stage 1, grade 3, ER/PR pos. HER2 pos. clear margins, no nodes. SNB. 35 rads. On Zoladex and Armidex since Dec. 2004. Stopped Zoladex/Arimidex sept 2009 Still taking mistletoe shots (CAM therapy) Doing fine.
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01-25-2011, 11:14 AM
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#7
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
I had my dentist look into Stevia as an option for helping with weight loss to make sure there were no dental issues with it, and in his opinion Stevia is fine to use. But because my SO has had bone loss, maybe xylitol would work even better...
A.A.
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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01-25-2011, 12:54 PM
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#8
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
I have been using a nasal spray that contains Xylitol for a couple of years. It really helps me fight off oncoming colds!
I use it also more during the worst of the allergy seasons and it seems to help keep my sinuses clear a little longer.
But I imagine to get a broader health benefit one would need to ingest a larger amount?
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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01-25-2011, 03:53 PM
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#9
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Senior Member
Join Date: Feb 2008
Location: South East Wisconsin
Posts: 3,431
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
I don't have it handy, but I know I have encountered research suggesting Stevia has anticancer properties.
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01-25-2011, 05:48 PM
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#10
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Senior Member
Join Date: Mar 2008
Location: Illinois
Posts: 25
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
Anyone know how sugar feeds cancer cells? I don't touch it, but I do wonder about the sugar in fruit. A nurse friend told me that because I don't use sugar and no white flour,rice etc. that the cancer cells don't want to grow. Hope she's right!!! I feel great on a very healthy diet. What is the "Pink Diet"? I haven't been to the site for a long time.
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01-25-2011, 06:41 PM
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#11
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Senior Member
Join Date: Sep 2009
Location: Kensington, CT
Posts: 394
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
One of my good friends swears that I got BC from all the Diet Coke I consumed over the years. Got hooked on the stuff back in the Tab days. Too late now for me.
I suppose anything that's not natural is probably not too good for you. After reading the China Study, The Anti-cancer Diet, Crazy Sexy Cancer, they say all the same thing to stay away from the fake food; including artificial sweetners.
Kris...
__________________
06/08/09 - 55, IDC, IIIA, ER+/PR-/HER+++
Nottingham 6/9 - Grade 2 5.2cm, several nodes
06/23/09 - Neoadjuvant - TCH Herceptin til June
10/07/09 - Finished Chemo
10/27/09 - Mastectomy RB
Path Report: RB No residual tumor pCR,
2 of 15 pos - .5mm largest micromets
12/18/09 - Radiation started (28)
02/05/10 - Finished Radiation
01/11/10 - Started Femara
06/22/10 - Finished Herceptin.. My son's 22nd BD. Hope it's a sign! Hoping for the best.
11/15/10 - Started Walter Reed BC Vaccine trial at
1/04/11 - Sibley Mem. Had to withdraw due to met
01/23/11 - Stage IV - Brain Met 1.6cm 1.7cm
02/03/11 - Gamma Knife (2 fracts to minmize necrosis)
03/01/11 - Gamma Knife
6/11 - Necrosis
7/11 - Necrosis stopped & Tumor progression
8/11 = Now think it's really necrosis
9/11 - Avastin every two weeks -- It's working!! Necrosis is shrinking.
12/11 - Necrosis gone AVASTIN worked.
12/11 - Bone &CT found
Oct '10 - Ran Hartford 1/2 Marathon to Thank Dr. Slamon for Herceptin!
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01-25-2011, 08:05 PM
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#12
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Re: some artificial sweeteners and probiotics may inhibit breast cancer growth(in mic
Alyce, several members are interested in a plant-based olive oil diet that is published as the Pink Ribbon Diet, and requested a presentation for it. I don't know if that is the diet you are thinking of. It is being discussed this coming Saturday USA time/Sunday Aussie time:
http://her2support.org/vbulletin/showthread.php?t=45472
AlaskaAngel
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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