important new report: benefit of TDM1 after herceptin + perjeta raises?

[schoonder]

More work is ongoing to improve on t-dm1 based therapy. Following is an excerpt from a recently published world patent application:

"[159] As can be seen with reference to Figure 7, percent survival was dramatically higher when the agonist antibody (anti-CD137) was included, as compared with when an anti-tumor antibody (specifically trastuzumab or T-DM1 ) was utilized alone. Improved survival rates were observed for both trastuzumab and T-DM1 when agonist antibody was included. Moreover, Figure 6 documents the surprising finding that the improvement in percent survival achieved when anti- CD137 agonist therapy is added to T-DM1 therapy is dramatically more significant than that observed when anti-CD137 agonist therapy is added to trastuzumab therapy, notwithstanding that T-DM1 and trastuzumab target the same tumor antigen (HER2) and, moreover that T-DM1 includes the identical trastuzumab antibody, differing from trastuzumab in that the antibody is conjugated with DM1."

Hopefully Roche will apply this new methodology of treatment in a new clinical trial to translate these dramatical improvements into real life options.

https://worldwide.espacenet.com/publ...&locale=en_EP#

[phil]

what are these other agents besides t dm-1 ? " anti cd347 " , etc. in laymans' terms . immuno therapies ?
the paper keps talking about diferneces in effectiveness between her and t dm-1 . t dm-1 has a chemo, herc is no ta chemo. same with perjeta . not a chemo. that is why I advise stage iv her2 pts who are on herc or herc/ perjeta, who have previously to pert. progressed on herc with taxanes or other tx.'s to still get scanned very regularly, and get blood markers very regularly. perjeta and herc. are not chemos. I have seen some pts do very well on herc/ perj for 2 yrs or so then have the cancer come back . the sooner caught , the potentially smaller target for t dm-1 to hopefully kill.
I wish t dm-1 was around to be used on my wife's one lone liver tumor back in 06 - but it was just in very early phase I testing. we did benefit from an aggressive doc who kept cancer around liver until t dm-1 came along. I feel t dm-1 will be used in future for those w/ strong her2 only overexpression like Lorraine . right at the beginning of stage iv spread or prophylactically , before potential spread.

[RobinP]

Still think shorter 9 week of Herceptin effective as in the Fin. Trail.