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Old 12-04-2014, 05:21 PM   #1
Lani
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Join Date: Mar 2006
Posts: 4,778
Thumbs up highly recommended article by M. Scaltriti re predicting those who respond best

to herceptin + lapatinib combination, theorizing how the article's findings could identify those who could be treated with the antiher2 combination without chemo.

Still a work in progress, the progress is accelerating dramatically and this article is worth the $3.50 you may have to spend as a patient to access it.

Remember the chocolate, whipped cream, cherries, strawberries and puppydogs
when attempting to read it...

http://clincancerres.aacrjournals.or...R-14-1824.long

Best of luck!
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Old 12-04-2014, 07:30 PM   #2
linn65
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Join Date: Dec 2012
Location: Attica, IN
Posts: 371
Re: highly recommended article by M. Scaltriti re predicting those who respond best

Can't you break it down for us?? I rather eat all the above accept the puppy dog of course.
__________________
myleftlump.wordpress.com - started blogging my
IDC breast cancer
7/2012 diagnosed with multiple solid lesions
7/20/12 biopsy done. ER+ 30 PR -, HER+++,k167 80% Grade 2
9/2012 biopsy on lymph node - showed malignant

9/2012 Pre-adjunctive TCH chemo.

12/6/12 MRI after Pre-adj.
Results: Modest Decrease in size of left breast malignancy As well as the associated satellite lesions and auxiliary Adenopathy compared to prior study. Doctors hoped for better but good response it didn't grow.

12/18/2012 left masectomy with axillary nodes
Size 3.2 CM, Nottingham score 9/9
Grade 3, no evidence of in situ carcinoma
Areas of angiolymphatic are identified
Carcinoma is 0.5 cm from inked deep
Margin of excision
Attached axillary lymph nodes: metastatic
Carcinoma in 6 of 8 nodes.
Size of largest node 1.5 cm
Extracapsular
ER + 73%, PR+2%, HER2+

2/27/13 6 weeks of IMRT radiation finished

2/2013 Started on Tamoxifan 5 years.

8/2013 will take last Herceptin, 17 treatments total every 3 weeks.

BRCA1 & BRAC2 - Negative

August 28, 2013 DIEP flap on the left breast.
February 2014 Nip & Tuck
March 14, 2014 nipple reconstruction and removed port.
August 14, 2014 lump in lymph nodes under arm and above clavicle. Stage IV
August 28, 2014 herceptin And projeta starting and port put back in.

3/18/15 stopped arimidex.
3/18/15 progression....Tdm1
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