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Old 04-24-2013, 05:59 AM   #1
NEDenise
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Avastin shrinks necrosis?

Mornin' friends...

My doc suggested trying Avastin to shrink the necrotic tissue in my brain. (Gotta get me off these steroids!)

Anybody have any experience, expertise, or info about this?
Denise
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1/11-needle biopsy
2/11-Lumpectomy/axillary node dissection - Stage 3c, ER/PR-14/17 nodes
3/11 - Post-op staph infection,cellulitis, lymphedema,seroma,ARRRGH!
4/12/11-A/C x 4, then T/H x 4, H only,Q3 weeks
8/26/11 finished Taxol!!!
10/7/11 mastectomy/DIEP recon
11/11 radiation x28
1/12/12 1st CANCER-VERSARY!
1/12 Low EF/Herceptin "Holiday" :(
2/12 EF up - Back on Herceptin, heart meds
4/2/1212 surgery to repair separated incision from DIEP recon
6/8/12 Return to work :)
6/17/12 Fall, shatter wrist,surgery to repair/insert plate :(
7/10/12 last Herceptin
7/23/12 Brain Mets %$&#! 3cm and 1cm
8/10/12 Gamma knife surgery, LOTS of steroids;start H/Tykerb
8/23/12 Back to work
12/20/12 Injure back-3 weeks in wheel chair
1/12/13 2nd CANCER-VERSARY!
1/14/13 herniate disk in back - surgery to repair
1/27/13 Radiation necrosis - edema in brain - back on steroids - but not back to work - off balance, poor cordination in right arm
5/3/13 Start Avastin to shrink necrosis
5/10/13 begin weaning steroids
6/18/13 Brain MRI - Avastin seems to be working!
6/20/13 quarterly CT - chest, abdomen, pelvis - All Clear!
7/5/13 finally off steroids!!
7/7/13 joined the ranks of the CHEMO NINJAS I am now Tekuto Ki Ariku cancer assassin!
7/13/13 Symptoms return - back on steroids
7/26/13 Back on Avastin - try again!
8/26/13 Not ready to return to classroom yet :( But I CAN walk without holding onto things! :)
9/9/13 Brain MRI - fingers crossed
“ Life is a grindstone, and whether it grinds you down or polishes you up is for you, and you alone, to decide. ” – Cavett Robert
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Old 04-24-2013, 11:52 AM   #2
ammebarb
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Re: Avastin shrinks necrosis?

Hi Denise. Interestingly enough, I am receiving Avastin injections into my irradiated eye for the purpose of reducing bad effects of the "zapping". It is said to work on weak, weepy, blood vessels and fluid build up in the eye. It had been tried as a chemotherapeutic agent, but didn't do the job for eye cancer. It's purpose now is to help preserve vision for me. I've had two and will have my next in August. Has it been used in the brain before? My best wishes for great result, Denise. Let us know if you decide to do it.

Barb A.
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Old 04-24-2013, 06:18 PM   #3
dearjilly
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Re: Avastin shrinks necrosis?

Preserve vision? Sign me up for this Avastin. My goodness, I am going to ask my MO about this on Friday. I am desperate for anything to preserve my vision too. It's just gotten worse since the radiation to my brain met.
Denise, read this: http://www.naturalnews.com/034009_boswellia_inflammation.html
It's about an non steroidal anti inflammatory drug, an herb, for swelling and it even says it works on tumour necrosis. HUH?!
Jill
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[
Feb 2013 - NED
Mar 2013 - thought I had progression, watching brain.
April 2013 - GOT MARRIED!!!!
May 2013 - looks like no progression, but necrosis and bigger.
Oct-Dec 2013 - Avastin tx
Nov 2013 - MRI shows necrosis shrinkage!!!!
Jan 2014 - Lepto Mening. disease found
Feb 2014 - WBR
March - BLAHHHH
April 2014 - Liver mets found
April 2014 to present - Chemo again, whooohoo. Fun!
July 2014, scans look good.
Stay on Perjetand hercertin.
Nov. 2014 more lepto-mening disease more WBR.
Feb 2015 more lepto-mening disease in spine and neck. More radiation.
Start on TDM1 no more Perjeta stay on herceptin
March 2015 more radiation in my thoracic area, more lepto-meningial disease
April 2015 trying to walk again.
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Old 05-01-2013, 09:49 AM   #4
Andrea Barnett Budin
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Location: LAND OF YES! w/home in Boca Raton, Florida Orig from L.I., N.Y. Ever hovering IN THE NOW...
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Re: Avastin shrinks necrosis?

HEY DENISE, AND EVERYONE CHECKING UP ON HER --

I have a wonderful friend who was having eye problems. She's older than me/older than dirt... )

Her optphamologist told her to come back in 6 mnths. WRONG. Her vision got worse. She went to Baskin Parmer down here/top eye institution. She'd lost half the vision in one eye. They injected Avastin into her eye. And she returned ev few mnths for more. HELPED TREMENDOUSLY!!!!!!!!!


Avastin Reduces Brain Necrosis from Radiation


Effect of Bevacizumab on Radiation-induced Brain Necrosis in Patients With Nasopharyngeal Carcinoma - Full Text View - Clinical


Inflammation reduction with diet, herbs and supplements, causes and treatment
speaks of Jilly's Boswellia Serrata

Always thinking of you my Sisters...

With love,
Andi
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Andi BB
'95 post-meno dx Invasive LOBULAR w/9cm tumor! YIKES + 2/21 nodes. Clear mammo 10 mnths earlier. Mastec/tram flap reconst/PORT/8 mnths chemo (4Adria/8CMF). Borderline ER/PR. Tamoxifen 2 yrs. Felt BLESSED. I could walk and talk, feed and bathe myself! I KNEW I would survive...

'98 -- multiple mets to liver. HER2+ 80%. ER/PR- Raging, highly aggressive tumors spreading fast. New PORT. 9 mnths Taxotere Fought fire w/fire! Pronounced in cautious remission 5/99. Taxotere weekly for 6 wks, 2 wks off -- for 9 mnths. TALK ABOUT GRUELING! (I believe they've altered that protocol since those days -- sure hope so!!)
+ good old Vit H wkly for 1st 3 yrs, then triple dosage ev 3 wks for 7 yrs more... The "easy" chemo, right?! Not a walk in the park, but not a freight train coming at 'ya either...

Added Herceptin Nov '98 (6 wks after FDA fast-tracked it for met bc). Stayed w/Vit H till July '08! Now I AM FREE! Humbly and eternally grateful for this life-saving drug! NED since '99 and planning on keeping it that way. To hell w/poor prognosis and nasty stats! STOPPED VIT H JULY '08...! REMAIN STABLE... Eternally grateful...Yes is a world & in this world of yes live (skillfully curled) all worlds ... (e e cummings) EVERY DAY I BEAT MY PREVIOUS RECORD FOR # OF CONSECUTIVE DAYS I'VE STAYED ALIVE. Smile KNOWING you too can be a miracle. Up to me and God now...
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