Lapatinib/Xeloda dosing

[mkrny]

My wife finally got started in the trial today. We are both very hopeful that this trial is the cocktail that succeeds in beating Maryann's cancer.

Cycle is 21 days, Her dose is:
*Lapatinib 1250 mg once/day, d 1-21
*Xeloda in the morning 2000mg, d 1-14
*Xeloda in the evening 1500mg (12 hrs between xeloda doses), d 1-14

In her previous cocktail she took 1500 mg xeloda d 1-14 w/ navelbine and herceptin. That's a big difference but I guess w/o the second chemo agent more than double the dose is appropriate??

Are other folks in lapatinib/xeloda trial taking similar doses and following similar schedule?

For those computing based on volume, she is 5'7" and 135 lbs

I'll follow up directly with Paul if he doesn't see this

Ken & Maryann

[Lolly]

Wow. That's a big dose. I don't know what other's in the trial are taking, but maybe you could also post this on the main board to make sure it's seen, hopefully get some feedback from others who are more knowledgeable.