Rapamycin and dasatinib combination may be beneficial in treating breast cancer, say

[News]

The uncontrolled growth of cancer cells arises from their ability to hijack the cell’s normal growth program and checkpoints. Usually after therapy, a second cancer-signaling pathway will open after the primary one shuts down — creating an ingenious escape route for the cancer cell to survive. The answer, say Case Western Reserve researchers, is to anticipate and block that back-up track by prescribing two drugs from the start.

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[donocco]

This is interesting. Affinitor is very similar to Rapamycin. Sprycel was developed as an antiLeukemic drug ie Philadelphia Chromosome positive chronic and acute Leukemias. It fights Leukemia by inhibiting a TK enzyme called BCR-ABL. I didn't know it also inhibited SRC kinases. Way back in 1911, a microbiologist named Peyton Rous was able to transmit a chicken sarcoma to healthy chickens by injecting them with ground up fluid from chickens with this sarcoma. First he ran the fluid through a millipore filter to remove any bacteria. The filter was too large to remove viruses, and this chicken sarcoma was the first cancer to be found to be caused by a virus. The virus contains the SRC oncogene in its genetic material, and the SRC stands for sarcoma.

The dose of Sprycel for Leukemia is 100 to 140mg daily. Its not without side effects causing Muscle pain, rash, anemia, neutropenia, thrombocytopenia, GI bleeding (possible) edema, fever and fatigue.

Paul