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Old 03-07-2012, 03:50 PM   #1
Jackie07
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T-DM1 new sites

7 and counting just posted info on new T-DM1 sites on the Her2 Forum:

http://her2support.org/vbulletin/showthread.php?t=53391
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Old 03-08-2012, 09:16 AM   #2
Emelie B
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Re: T-DM1 new sites

This may be a dumb question, but it states you must have been treated with two HER2- biologic treatments. Does anyone know what the 2 treatments are? Is it Herceptin and Tykerb?
Thanks for any assistance.
Emelie
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Nov. 2006-IDC with Her2 +++
A/C for 3 rounds
Dec. 2006- Herceptin and Taxotere
March 2007-MRM with 8 of 14 lymph node involvement
May 2007-36 Rads
Sept. 2007- Stopped Herceptin
Jan. 2010- CT scan shows enlarged lymph nodes in sternum and lung involvement
Feb. 2010-PET scan shows mets to liver, lung, lymph nodes and bone
Feb. 2010- Started Herceptin/Taxol and Zometa
April 2010-PET scan clear. Herceptin and Zometa
June 2010- Stopped Herceptin continue Zometa and still NED
August 2010-Back on Herceptin and Zometa every 3 weeks
August 13, 2010- Had another port placed
August 24, 2010- PET scan clear. Herceptin and Zometa every three weeks
Nov. 2010-PET scan clear
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March 2011- PET scan clear
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Old 03-23-2012, 01:45 PM   #3
Shaysmom
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Re: T-DM1 new sites

I just started this trial , however I was one of the 1/3 of the pts randomized NOT to get TDM1.

It took me almost 4 weeks to get on trial just to be back on regular chemo. My oncologist was very upset just bc she said she wishes I could catch a break.

The two previous targeted therapies are Herceptin and Tykerb.
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10/01-8/02 mastectomy, chemo, XRT
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10/02-10/09 Herceptin, cancer NED or stable
11/09 dx mets for 3cm medisternal mass,
start Xeloda and Herceptin
07/10 dx with mets to adrenal gland and suspicious nodules in pleural stay on Xeloda and watch
11/10 more progression
12/10 start Abraxne Herceptin once week 3 weeks one week off.
10/6/11 PET showed adrenal is very active and new mets in internal mammary
11/1/11 Start tykerb and Aromasin
2/2012 endo dx stomachmets.
3/2012 randomized to non tdm1 arm of Teresa trial.
Started Gemzar
7/27/2012 progression but too small to switch
9/10/2012 now new lymphnode b/w stomach and liver off Gemzar Still no TDM1 crossover
10/3/2012. started perjeta, herceptin, taxotere
12/2012 losing weight from constant big D, scans are stable
1/3/2013 start TDM-1 xover for Teresa trial.
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Old 03-29-2012, 09:00 AM   #4
schoonder
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Re: T-DM1 new sites

Th3resa clinicaltrials.gov new sites recruiting and/or added to list.
http://clinicaltrials.gov/archive/NC..._02_22/changes
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Old 05-08-2012, 09:03 AM   #5
Emy
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Re: T-DM1 new sites

I had 9 months of Herceptin. Stopped working. Took Herceptin and Tykerb 1500 a day, no reactions,not working, cancer in all sites doubling rapidly in size..PET scan and tumour markers confirm....What is next? How can I get into a trial
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Old 05-08-2012, 09:49 AM   #6
schoonder
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Re: T-DM1 new sites

Emy,

The TH3RESA ClinicalTrials.gov identifier= NCT01419197
Contact: Genentech Trial Information Support Line888-662-6728 (U.S. Only) for further particulars.


Link to clinicaltrials.gov for this trial = http://www.clinicaltrials.gov/ct2/sh...ow_locs=Y#locn

Hope this helps.
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Old 05-08-2012, 09:56 AM   #7
Emy
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Re: T-DM1 new sites

I had 9 months of Herceptin. Stopped working. Took Herceptin and Tykerb 1500 a day, no reactions,not working, cancer in all sites doubling rapidly in size..PET scan and tumour markers confirm....What is next? How can I get into a trial
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Old 05-08-2012, 11:16 AM   #8
ElaineM
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Wink Re: T-DM1 new sites

Emy,
Call Genetech and see what T DM1 trials might work for you. The Genetech number is in the thread about EAP for T DM1. Or you can go to www.clinicaltrials.gov and do a search for TDM1 trials.
Have you had a few different chemo and Herceptin combos? Have you had a Tykerb and chemo combo?
Talk to your doctor or get a second opinion about what is out there for you. Good luck.
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