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Old 10-19-2013, 08:06 PM   #1
'lizbeth
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Post Fish Oil vs Cox-2 inhibitor in Pregnancy Associated Breast Cancer

Window of Opportunity Study Targeting the Inflammatory Milieu

This study is currently recruiting participants.
Verified June 2013 by University of Colorado, Denver
Sponsor:
University of Colorado, Denver
Collaborator:
University of Colorado Hospital
Information provided by (Responsible Party):
University of Colorado, Denver

ClinicalTrials.gov Identifier:
NCT01881048
First received: June 14, 2013
Last updated: June 18, 2013
Last verified: June 2013
History of Changes


Purpose The purpose of this study is to evaluate the effect of two anti-inflammatory drugs, fish oil capsules and the COX-2 inhibitor celecoxib, on pregnancy associated breast cancer (PABC). Short-term intervention with anti-inflammatory medications will demonstrate a reduction in the inflammation and immune suppressive phenotype of PABC, and decreased metastatic potential in PABC. This unique window in breast cancer management serves as a valuable opportunity to obtain preliminary data on biomarkers and the alterations that occur when the system is troubled by a drug or other intervention which will be instrumental in designing future therapeutic or preventative strategies for larger clinical study.


Detailed Description:
This randomized pilot clinical trial studies omega-3 fatty acid or celecoxib in treating patients with breast cancer planning to undergo surgery. Omega-3 fatty acid may stimulate the immune system in different ways and stop tumor cells from growing. Celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether omega-3 fatty acid or celecoxib is more effective in treating breast cancer.


With the board's many Omega-3 vs Omerga-6 discussions I thought this would be an interesting clinical trial to watch.
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