RATIONALE: Drugs used in chemotherapy, such as carboplatin and paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab and trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Giving more than one drug (combination chemotherapy) and monoclonal antibody therapy together before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
PURPOSE: This phase II is studying the side effects and how well giving carboplatin and paclitaxel albumin-stabilized nanoparticle formulation together with bevacizumab or trastuzumab before surgery works in treating women with stage II or stage III breast cancer.
Chao Family Comprehensive Cancer Center Recruiting
Orange, California, United States, 92868
Contact 877-827-8839 UCstudy@uci.edu
Principal Investigator: Rita Mehta, M.D.