Clinical trial for Pre menopausal Women who are ER+, PR+ to compare tamoxifen with ov

[Becky]

Dear Astrid


Tamoxifen does not suppress estrogen manufacture by the ovaries, adrenals or adipose tissue. Tamoxifen covers the estrogen receptor on the surface of breast/breast cancer cells so that estrogen cannot bind there. If estrogen does bind, it causes the excitation of the cell that leads to proliferation/reproduction.

This is why your estrogen levels are normal for a premenopausal/perimenopausal woman (because there is no ovarian suppression involved with Tamoxifen alone).

Kind regards

Becky